Perricone MD Chlorophyll Detox Mask for oily acne-prone skin

How to apply

Questions and answers

What the research says

• An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.

  Clinical, Cosmetic and Investigational Dermatology, 2019

• A bentonite-based facial mask with Alcea sulphurea extract combined with oral azithromycin significantly reduced total lesion count and acne severity index while enhancing patient satisfaction in patients with moderate acne compared to placebo plus azithromycin over 8 weeks.

  Journal of Cosmetic Dermatology, 2025

• Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy.

  Journal of Cosmetic Dermatology, 2021

• Topical application of sodium copper chlorophyllin complex significantly improved mild-moderate photodamage and solar lentigenes compared to baseline in women over an 8-week period.

  Journal of Drugs in Dermatology, 2015

• Sodium copper chlorophyllin complex 0.05% gel significantly increased fibrillin/amyloid P and epidermal mucins and increased procollagen 1 and dermal mucin in photoaged forearm skin of four healthy females compared to an untreated negative control.

  Clinical, Cosmetic and Investigational Dermatology, 2016

• Topical application of sodium copper chlorophyllin complex improved clinical efficacy parameters in 10 subjects with mild-moderate acne and large, visible pores over 3 weeks compared to baseline.

  Journal of Drugs in Dermatology, 2015

• Herba Schizonepetae oil microcapsules provided effective repellent protection for hand skin against Aedes albopictus Skuse for 4-5 hours.

  Transactions of the Royal Society of Tropical Medicine and Hygiene, 2013

• High-content actives encapsulated in alcohol-solvent microcapsules with palm oil shells enhanced skin efficacy and mediated transdermal delivery without causing skin irritation in clinical trials.

  Biomaterials Science, 2023

• A novel microcapsule composite Spherulites Peony Superior Retinol mitigated UVB-induced skin damage by eliminating ROS, reducing DNA damage and inflammatory factors, and restoring extracellular matrix-related protein gene expression in vitro and in vivo.

  Photochemistry and Photobiology, 2025

• Oral bromelain slightly reduced pain compared to controls (mean difference -0.27) and topical bromelain reduced time to complete debridement by 6.89 days, with no major health risks reported.

  Nutrition and Health, 2023

• An upcycled pineapple leaf fibre crosspolymer forms a physical barrier that protects against environmental aggressors while providing antioxidant, anti-inflammatory, antipollution, UV protection, hydration, and hair benefits.

  International Journal of Cosmetic Science, 2026

• A coaxial electrospun core-shell nanofiber scaffold delivering bromelain and salvianolic acid B demonstrated sustained drug release, in vitro endothelial cell migration, increased capillary formation in an in ovo assay, and in vivo efficacy for skin regeneration and wound healing.

  Biomedical Materials, 2017

• Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo.

  Wilderness & Environmental Medicine, 2016

• A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face.

  Giornale Italiano Di Dermatologia E Venereologia, 2015

• Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation.

  Molecules, 2020

• A dermocosmetic cream containing Punica granatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis significantly decreased inflammatory, non-inflammatory, and total lesion counts in subjects with mild to moderate acne compared to untreated hemi-faces after 15 days.

  Journal of Cosmetic Dermatology, 2026

• Daily use of a deep cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% significantly reduced total lesion count by 56.3% after 84 days in 35 subjects with mild to moderate truncal acne.

  Clinical, Cosmetic and Investigational Dermatology, 2023

• Different strains of Propionibacterium acnes modulate cutaneous innate immunity with varying pro-inflammatory potentials, with P. acnes type III showing the highest and P. avidum the weakest, and zinc gluconate down-regulates the expression of most induced immune markers.

  Experimental Dermatology, 2013

Why other cleansing masks fit oily acne-prone skin better

• Chemical peels with 30% supramolecular salicylic acid effectively treated acne and reduced facial sebum secretion while improving skin hydration and barrier function in 25 patients.

  Journal of Cosmetic Dermatology, 2022

• A 30% supramolecular salicylic acid peel improved the global acne grading score and skin barrier indicators, decreased cutaneous microbiome richness and evenness along with Staphylococcus proportion, reduced inflammatory cytokines, and increased caveolin-1 expression in 28 patients with moderate-to-severe acne vulgaris.

  Dermatology and Therapy, 2023

• Two percent supramolecular salicylic acid showed similar efficacy to 0.01% adapalene plus 5% benzoyl peroxide in reducing acne lesions in 31 patients over 28 days.

  Cutaneous and Ocular Toxicology, 2019

Ingredients

Water, Glycerin, Bentonite, Peg-40 Hydrogenated Castor Oil, Titanium Dioxide Ci 77891, Coco-Caprylate, Magnesium Aluminum Silicate, Diglycerin, Mannitol, Butylene Glycol, Methyl Gluceth-20, Microcrystalline Cellulose, Dimethylaminoethanol Tartrate, Ethylhexylglycerin, Xanthan Gum, Bromelain, Papain, Allantoin, Magnesium Aspartate, Zinc Gluconate, Beta-Glucan, Chlorophyllin-Copper Complex, Copper Gluconate, Nasturtium Officinale Leaf Extract Flower, Camellia Sinensis Leaf Extract, Spirulina Platensis Extract, Citric Acid, Sodium Benzotriazolyl Butylphenol Sulfonate, Disodium Edta, Maltodextrin, Polyacrylamide, Caprylyl Glycol, Buteth-3, C13-14 Isoparaffin, Hexylene Glycol, Acrylates Copolymer, Laureth-7, Propylene Glycol, Hydroxypropyl Methylcellulose, Tributyl Citrate, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, Eucalyptus Globulus Oil Leaf, Iron Oxides Ci 77492, Chromium Hydroxide Green Ci 77289, Barium Sulfate, Iron Oxides Ci 77499, Silica

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.