PCA SKIN Rejuvenating Serum for sensitive skin
Niacinamide
Glutathione
Squalane
Epigallocatechin Gallate
Aloe Barbadensis Leaf JuiceAverage
- AverageNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for sensitive skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for normal skin, as Glycerin and Sodium PCA provide humectant action to support hydration, but lacks sufficient emollients like Squalane to fully address potential dryness.
- The serum provides general skincare benefits, such as hydration and soothing, which are supportive for your redness and irritation due to Bisabolol and Aloe Barbadensis Leaf Juice, but these ingredients are not specialized enough to directly address your sensitivity.
- The safety profile is excellent, with no risks of irritation for your sensitive skin due to the absence of prohibited or harsh ingredients and the presence of soothing ingredients like Bisabolol and Aloe Barbadensis Leaf Juice.
How to apply
- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
People Say
★4.6Overall rating based on 200+ reviewsThis product is highly praised for improving skin texture, reducing fine lines, and providing a radiant glow. Users frequently mention its lightweight, fast-absorbing formula. Some users with sensitive skin find the alcohol-heavy base to be drying or irritating.
Highlights
Improves radiance Mostly Mentioned
- “Leaves my skin glowing and refreshed.”
- “It did seem to make my skin more radiant.”
- “Gives your skin such a beautiful glow.”
Lightweight texture Often Mentioned
- “Absorbs quickly and does not feel sticky.”
- “Not greasy and heavy.”
- “Easy to apply, absorbs quickly.”
Reduces fine lines Often Mentioned
- “Improvement in fine lines.”
- “Amazing for plumping and filling in fine lines.”
- “Decreasing the depth of lines.”
Refreshing experience Sometimes Noted
- “Love the light tingling/refreshing feeling.”
- “Smells amazing (very minty).”
- “Cooling sensation right away.”
Drying formula Sometimes Noted
- “Alcohol denat. ... can be drying and irritating.”
- “Strips barrier lipids and can trigger inflammation.”
High price Sometimes Noted
- “Was just a little too expensive.”
Irritating ingredients Rarely Noted
- “Peppermint oil ... is a known sensitizer.”
- “Citrus oils are a frustrating contradiction.”
Lack of results Rarely Noted
- “Not sure I'm seeing much difference.”
Sources: lovi.care, dermapproved.com, lovelyskin.com, influenster.com, dermstore.com, dermstreet.com, and more
Questions and answers
How well does PCA SKIN Rejuvenating Serum work for sensitive skin?
PCA SKIN Rejuvenating Serum works moderately well for sensitive skin, as it contains soothing ingredients like aloe and bisabolol to help calm redness and irritation without causing negative reactions. However, it lacks enough rich softening ingredients to fully prevent dryness, and a treatment for this skin needs specialized calming components and deep moisturizers to keep it completely comfortable.
Which ingredients make this serum a good fit for sensitive skin?
Niacinamide, bisabolol, and aloe barbadensis leaf juice make this serum a good fit for sensitive skin by offering soothing benefits for redness and irritation without causing adverse reactions. This treatment of average fit needs specialized soothing ingredients and rich moisturizers like squalane to fully care for sensitive skin.
What does Niacinamide do for sensitive skin?
Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
What does Glutathione do for sensitive skin?
Glutathione helps calm sensitive skin by reducing oxidative stress and protecting against environmental irritation. It is unlikely to cause irritation and has a very safe profile when used on the skin.
Journal of the European Academy of Dermatology and Venereology, 2024Indian Journal of Dermatology, Venereology and Leprology, 2016
Where does this serum go in a skincare routine for sensitive skin?
This treatment serum goes in your evening routine after toning and before moisturizing, though products for this skin also need extra soothing and deeply nourishing ingredients to fully calm sensitivity and dryness.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to clean skin and following with your retinol. Because this serum has a very safe formula with soothing ingredients like bisabolol and aloe vera, it is unlikely to cause irritation when paired with a retinoid.
How often should I use this serum?
This serum works in the evening routine, and sensitive skin needs a product with richer softening ingredients to prevent dryness.
Can this serum clog pores, cause breakouts or purging for sensitive skin?
This serum is unlikely to cause irritation or breakouts on sensitive skin, as it has a very safe formula with soothing ingredients like aloe and bisabolol. However, because it works best with more nourishing moisturizers to keep dry skin comfortable, a product for this skin needs richer smoothing ingredients and extra hydration.
Is this serum fragrance-free and alcohol-free?
It has no fragrance and contains drying alcohol (sd alcohol 40-b).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017A novel natural carrier-free assembled gel composed of sodium pyrrolidone carboxylate and baicalin alleviates UVB-induced skin photodamage by scavenging reactive oxygen species, protecting mitochondria, restoring oxidative homeostasis, inhibiting inflammatory responses, and regulating collagen-related proteins.
Biomaterials Advances, 2026A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.
Clinical Pharmacology, 2018Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction.
Journal of Clinical and Diagnostic Research, 2017Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo.
Experimental Dermatology, 2009An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.
Clinical, Cosmetic and Investigational Dermatology, 2019Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief.
Plastic and Reconstructive Surgery, 2018Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo.
Journal of Alternative and Complementary Medicine, 2010Formulations containing 0.10%, 0.25%, and 0.50% freeze-dried Aloe vera extract increased stratum corneum water content compared with the vehicle in 20 female subjects, while transepidermal water loss was not modified.
Skin Research and Technology, 2006
Ingredients
Water, Sd Alcohol 40-B, Glycerin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Gluconolactone, Polysorbate 20, Bisabolol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Isomalt, Sodium Pca, Sodium Lactate, Sodium Benzoate, Caprylyl Glycol, 1,2-Hexanediol, Peppermint Oil, Tocopherol, Squalane, Glutathione, Grapefruit Peel Oil, Citrus Aurantium Dulcis Peel Oil, Phytosterols, Tropolone, Epigallocatechin Gallate, Camellia Oleifera Leaf Extract, Aminomethyl Propanol, Tocotrienols, Squalene, Rice Bran Wax, Aloe Barbadensis Leaf Juice, Urea, Niacinamide, Glycine, Fructose, Vitis Vinifera Fruit Cell Extract Grape Fruit Cell Extract, Lecithin, Inositol, Rh-Oligopeptide-1
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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