# Paula's Choice Pro-Collagen Multi-Peptide Booster for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Paula's Choice](https://lovi.care/skincare/ae/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Excellent suitability for your normal skin and goals for wrinkles and fine lines is provided by the high concentrations of peptides like Palmitoyl Tripeptide-5 and Sh-Polypeptide-121, which stimulate collagen production and improve skin elasticity. Glycerin and Sodium Hyaluronate further support your skin's hydration and plumpness, enhancing the firming effects.
- The inclusion of ingredients like Hydrolyzed Yeast Extract and Polygonum Bistorta Root Extract offers additional antioxidant and soothing benefits, complementing the primary anti-aging function.
- This formula is safe for your skin, as it contains no harsh ingredients and includes soothing components like Glycerin and Sodium Hyaluronate.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/oily-acne-prone-skin): Average

## Key ingredients

6x Peptide Complex, Sodium Hyaluronate, Hydrolyzed Yeast Extract, Pyrus Malus Fruit Extract, Palmitoyl Tripeptide-5

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Topical moisturizers improved skin barrier function and surface moisture, while a postbiotic moisturizer with yeast extract uniquely supported microbiome balance and modulated biomarkers of skin barrier, structure, and inflammation in participants and ex vivo explants exposed to environmental aggressors. ([Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37763018/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A maintenance therapy with a cosmeceutical formulation containing hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid over 20 weeks significantly improved even skin tone, spot intensity, spot size, and overall hyperpigmentation in 33 healthy subjects with moderate facial dyspigmentation. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25844613/))
- A methanol yeast extract increases proliferation and migration while decreasing entrance into senescence and apoptosis phases in 3T3 fibroblast cells. ([Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/25898765/))
- Yeast extract from the A154 mutant strain increases cell viability by 1.4- to 1.9-fold in human skin cell lines (HFF, A431, HaCaT) after UVA irradiation and exhibits stronger ROS-scavenging properties compared with the parental strain. ([BMC Microbiology, 2026](https://pubmed.ncbi.nlm.nih.gov/42056863/))
- Topical formulations containing 1.25% Malus sp. extract or 0.75% rutin protected against UVB-induced sunburn cells, caspase-3 activation, cyclobutane pyrimidine dimers, lipid peroxidation, and metalloproteinase formation in ex vivo skin explants and 3D tissue-engineered skin. ([Rejuvenation Research, 2020](https://pubmed.ncbi.nlm.nih.gov/32242497/))

## What reviewers say

Users report this lightweight gel booster provides immediate plumping and hydration, often improving skin texture and softening fine lines overnight. While it is highly effective for firming and layering, a moderate number of users found the scent and price to be drawbacks, and a low number experienced breakouts or redness.

- Liked: Plumps and firms (mostly mentioned)
- Liked: Hydrates and glows (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Expensive for size (often mentioned)
- Liked: Smooths lines (sometimes noted)
- Disliked: Messy packaging (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice Pro-Collagen Multi-Peptide Booster one of the best fits for mature skin?

This booster is an exceptional fit for mature skin because its high concentrations of peptides like Palmitoyl Tripeptide-5 and Sh-Polypeptide-121 stimulate collagen production to improve elasticity and smooth out fine lines. Glycerin and Sodium Hyaluronate further boost hydration and plumpness to support the firming effects, while ingredients like Hydrolyzed Yeast Extract provide soothing and antioxidant benefits.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this booster a good fit for mature skin?

This booster is an excellent fit for mature skin thanks to peptides like Palmitoyl Tripeptide-5 and Sh-Polypeptide-121, which help build collagen and improve elasticity. Glycerin and Sodium Hyaluronate also work to keep your skin plump and hydrated, making fine lines less noticeable.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Peptide Complex do for mature skin?

Peptide Complex helps mature skin by smoothing fine lines and wrinkles while boosting firmness, elasticity, and hydration. These ingredients support aging skin by signaling it to increase collagen production, leading to a visibly revitalized and firmer look.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37335808/), [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39788697/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this booster go in a skincare routine for mature skin?

This booster goes in the evening routine after cleansing and before moisturizing, keeping things simple and safe around sun exposure. Some treatments can also be used in the morning or twice a day.

### Can I use this booster with retinol, and in what order?

You can use this booster with retinol by applying the booster first and following with your retinol product. This helps firm and hydrate your skin while keeping the routine gentle and effective.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this booster?

This booster is used in the evening for your mature skin, as part of your PM routine for simplicity and safety around sun exposure. It contains peptides, glycerin, and sodium hyaluronate, which help boost collagen, elasticity, hydration, and plumpness.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this booster clog pores, cause breakouts or purging for mature skin?

This booster is unlikely to cause breakouts for mature skin because it has a very low risk of clogging pores and features a safe formula with soothing ingredients like glycerin and sodium hyaluronate. Reviewers rarely mention breakouts, and the gentle ingredients help keep skin calm and smooth.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this booster fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — AED 347.75 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — AED 715.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ae/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — AED 65.43 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/ae/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — AED 493.00 at Amazon

## Where to buy

- Amazon.ae: AED 259.95 (https://www.amazon.ae/dp/B0BV3F1X4H?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Pentylene Glycol, Hydrolyzed Yeast Extract, Pyrus Malus Fruit Extract, Dimethicone, Propanediol, 1,2-Hexanediol, Glyceryl Glucoside, Palmitoyl Tripeptide-72 Amide, Sh-Polypeptide-121, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-5, Tridecapeptide-1, Polyglucuronic Acid, Sodium Hyaluronate, C9-12 Alkane, Ammonium Polyacryloyldimethyl Taurate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Polygonum Bistorta Root Extract, Bacillus Ferment, Lecithin, Sodium Phytate, Coco-Caprylate Caprate, Hexylene Glycol, Cetyl Hydroxyethylcellulose, Xanthan Gum, Ethylhexylglycerin, Caprylyl Glycol, Magnesium Chloride, Potassium Sorbate, Sodium Benzoate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin (this page)