Origins Original Skin Renewal Serum for acne-prone skin

How to apply

Questions and answers

What the research says

• Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability.

  Journal of Cosmetic Dermatology, 2024

• A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase.

  BioMed Research International, 2020

• The use of a salicylic acid-based dermocosmetic significantly reduces the needed quantity of benzoyl peroxide without impacting efficacy in mild to moderate acne, and as maintenance post-benzoyl peroxide allows a significant reduction of acne relapse compared to vehicle.

  Journal of Drugs in Dermatology, 2023

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

• Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.

  Journal of Cosmetic Dermatology, 2017

• Epilobium angustifolium extract increased cell viability, altered gene expressions in senescent normal human dermal fibroblasts, down-regulated UV-induced release of matrix metalloproteinases, and protected skin against UV-induced erythema formation in vivo.

  General Physiology and Biophysics, 2013

• Epilobium angustifolium extract reduces lipid synthesis in sebocytes, protects against Malassezia-induced morphological changes, and reduces nonadherent and adherent dandruff by -54% and -48% while inhibiting scalp sebum production by -67% in volunteers with dandruff and greasy scalp.

  Journal of Cosmetic Science, 2017

• Topical hydrogels containing Epilobium angustifolium extracts demonstrated antioxidant, antibacterial, anti-inflammatory, and wound-healing properties, with active ingredients penetrating human skin.

  Frontiers in Pharmacology, 2022

• Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.

  American Journal of Clinical Dermatology, 2013

• Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.

  European Journal of Neurology, 2013

• Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.

  Journal of Cosmetic and Laser Therapy, 2013

• Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients.

  CMAJ, 2010

• Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy.

  Journal of Cosmetic Dermatology, 2024

• Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients.

  Journal of the American Academy of Dermatology, 2010

• A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks.

  International Journal of Cosmetic Science, 2011

• Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects.

  Frontiers in Physiology, 2019

• Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid.

  AAPS PharmSciTech, 2021

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

Ingredients

Water, Butylene Glycol, Silica, Polymethylsilsesquioxane, Dimethicone, Glycerin, Hdi Trimethylol Hexyllactone Crosspolymer, Polysilicone-11, Grapefruit Peel Oil, Lavandula Angustifolia Oil Lavender Oil, Pelargonium Graveolens Oil Flower, Amyris Balsamifera Oil Bark, Salvia Sclarea Oil, Anthemis Nobilis Oil Flower, Rosa Centifolia Flower Extract, Limonene, Linalool, Epilobium Angustifolium Stem Extract Flower Leaf, Albizia Julibrissin Bark Extract, Chestnut Seed Extract, Salicylic Acid, Paeonia Suffruticosa Root Extract Paeonia Albiflora Root Extract, Molasses Saccharum Officinarum Extrait De Mélasse Extract, Laminaria Digitata Extract, Bambusa Vulgaris Extract, Pisum Sativum Extract, Sigesbeckia Orientalis Extract, Acetyl Hexapeptide-8, Ethylhexylglycerin, Caffeine, Urea, Lauryl Peg-9 Polydimethylsiloxyethyl Dimethicone, Arginine, Beeswax Alba Cire Dabeille Cera, Sodium Hyaluronate, Peg-11 Methyl Ether Dimethicone, Dimethicone Crosspolymer, Caprylyl Glycol, Sodium Pca, Dimethicone Vinyl Dimethicone Crosspolymer, Magnesium Ascorbyl Phosphate, Glucosamine Hcl, Sodium Phytate, Hexylene Glycol, Laureth-12, Trehalose, Polyquaternium-51, Tromethamine, Silica Silylate, Carbomer, Ammonium Acryloyldimethyltaurate Vp Copolymer, Tocopheryl Acetate, Potassium Sorbate, Chlorphenesin, Phenoxyethanol, Mica, Titanium Dioxide Ci 77891

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.