# NATURIUM Retinaldehyde Cream Serum 0.05% for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [NATURIUM](https://lovi.care/skincare/ae/brands/naturium)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for minimizing fine lines and wrinkles, as retinaldehyde and adenosine phosphate promote cell turnover and collagen synthesis, which is suitable for your normal skin.
- The formula provides general skincare benefits like hydration, with supportive effects for wrinkles and fine lines.
- The product is safe for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/naturium/retinaldehyde-cream-serum-0-05/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/naturium/retinaldehyde-cream-serum-0-05/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/naturium/retinaldehyde-cream-serum-0-05/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ae/p/naturium/retinaldehyde-cream-serum-0-05/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/naturium/retinaldehyde-cream-serum-0-05/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ae/p/naturium/retinaldehyde-cream-serum-0-05/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/naturium/retinaldehyde-cream-serum-0-05/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/naturium/retinaldehyde-cream-serum-0-05/for/oily-acne-prone-skin): Average

## Key ingredients

Retinaldehyde, Biofermented Oligopeptide, Retinal, Amino Acids, Punica Granatum Seed Extract

## What the research says

- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Mycosporine-like amino acids derived from the marine green alga Chlamydomonas hedleyi exhibited antioxidant, anti-inflammatory, and anti-skin aging activities by modulating the expression of UV-responsive genes in the human fibroblast cell line HaCaT. ([Marine Drugs, 2014](https://pubmed.ncbi.nlm.nih.gov/25317535/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Phenolic-rich pomegranate peel extract formulated into a serum and mask showed significantly better facial skin lightening efficacy than placebo in 30 volunteers over 28 days. ([Planta Medica, 2020](https://pubmed.ncbi.nlm.nih.gov/32428937/))
- Topical application of a 2% cream containing combined fruit extracts for 56 days significantly reduced wrinkle depth by 11.5%, length by 10.07%, and area by 29.55% in 21 female subjects compared to a placebo. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26203268/))
- A topical microemulsion containing Punica granatum extract significantly reduced skin erythema and melanin compared to a placebo in healthy Asian subjects over 12 weeks. ([Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25610348/))

## What reviewers say

This serum is widely praised as an excellent, gentle introduction to retinaldehyde, with users reporting visible improvements in skin texture, brightness, and acne control without the harsh irritation often associated with retinoids.

- Liked: Gentle & Non-irritating (mostly mentioned)
- Liked: Improves Texture & Tone (often mentioned)
- Liked: Pleasant Texture (often mentioned)
- Liked: Effective for Acne (sometimes noted)
- Liked: Great Value (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Breakouts/Purging (rarely noted)
- Disliked: Dryness (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Naturium Retinaldehyde Cream Serum 0.05% work for mature skin?

This product works moderately well for mature skin by offering some help with fine lines and wrinkles. Mature skin of this type needs a treatment that is exceptionally safe, targets wrinkles with high-quality ingredients, and combines potent antioxidants, hydrating components, and skin-repairing ingredients for optimal results.
Sources: [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### Which ingredients make this serum a good fit for mature skin?

Retinaldehyde and adenosine phosphate help smooth fine lines by encouraging skin renewal, making this serum a moderate fit for mature skin. To care for mature skin even better, a product of this type needs a combination of potent antioxidants, peptides, and hydrating ingredients that protect skin and boost elasticity without causing irritation.
Sources: [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### What does Retinal do for mature skin?

Retinal helps smooth fine lines, improve uneven skin tone, refine texture, and tighten pores on mature skin. It may also boost skin thickness and elasticity over time while keeping irritation low compared to stronger options.
Sources: [Journal of Drugs in Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39496127/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/30027612/)

### What does Biofermented Oligopeptide do for mature skin?

Biofermented oligopeptide helps support skin barrier function and improves overall skin quality when used regularly. It is generally safe and well-tolerated, though individual results may vary.
Sources: [ACS Synthetic Biology, 2025](https://pubmed.ncbi.nlm.nih.gov/40670299/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and toning, and before your moisturizer. Mature skin needs treatments with ingredients like peptides and retinoids to help smooth fine lines and support firmness.

### Can I use this serum with glycolic acid, and in what order?

You can use this serum with glycolic acid, but it is best to apply them on alternate nights to help prevent dry or irritated skin. Using both active ingredients at the same time may be too strong for your face and increase the likelihood of sensitivity.

### How often should I use this serum?

Use this treatment in your evening routine, starting once a week and slowly increasing frequency as your skin adjusts. Mature skin of this type needs a richer formula with deeply nourishing ingredients and stronger wrinkle-smoothing actives to better target fine lines.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or purging for mature skin, as reviewers rarely report them and the formula has a very safe profile. However, because this product offers only an average fit for your skin, mature skin needs formulas packed with nourishing peptides and rich hydrators to better smooth fine lines and boost firmness.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — AED 347.75 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — AED 715.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ae/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — AED 65.43 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/ae/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — AED 493.00 at Amazon

## Where to buy

- Amazon.ae: AED 81.53 (https://www.amazon.ae/dp/B0BJL2W71K?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Glycerin, Propanediol, Triheptanoin, C13-15 Alkane, Coco-Caprylate Caprate, Carbomer, Yeast Extract, Apricot Polyglyceryl-6 Esters Kernel Oil, Amino Acids, Punica Granatum Seed Extract, Cetyl Diglyceryl Tris Trimethylsiloxy Silylethyl Dimethicone, Hydrolyzed Yeast Extract, Olivine Extract, Dilinoleic Acid Butanediol Copolymer, Cellulose, Phenoxyethanol, Sorbitan Oleate, Sodium Metabisulfite, Retinal, Guanosine, Uracil, Polyacrylate Crosspolymer-6, C9-12 Alkane, Caprylyl Glycol, Polyglyceryl-10 Dipalmitate, Dipropylene Glycol, Sodium Hydroxide, Glyceryl Polyacrylate, Tocopherol, Pvm Ma Copolymer, Adenosine Phosphate, Castor Ipdi Copolymer Oil, Potassium Sorbate, Hexadecene, Sodium Benzoate, T-Butyl Alcohol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- France: https://lovi.care/skincare/fr/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/naturium/retinaldehyde-cream-serum-0-05/for/mature-skin (this page)