# NATURIUM Multi-Peptide Advanced Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [NATURIUM](https://lovi.care/skincare/ae/brands/naturium)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as Ferulic Acid and Glycerin provide antioxidant and humectant benefits, but it lacks sufficient ingredients for optimal oil control on your oily areas.
- The presence of peptides like Acetyl Hexapeptide-8 and Copper Palmitoyl Heptapeptide-14 offers excellent anti-aging effects, while Squalane and Glycerin provide general hydration that is supportive but not directly relevant to your oily shine.
- The safety profile is good, with no risks of irritation for your combination skin due to the absence of harsh ingredients and the inclusion of soothing agents like sunflower extract and rosemary leaf extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Multi-Peptide Blend, Ferulic Acid, Hydrolyzed Collagen, Squalane, Acetyl Hexapeptide-8

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A topical antioxidant solution of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid provides significant photoprotection against solar-simulated UV radiation in human skin compared to its vehicle. ([Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- A topical serum with a peptide blend showed superior or comparable skin recovery to a moisturizer following fractional CO2 laser and radiofrequency microneedling in Asian subjects. ([Dermatology and Therapy, 2026](https://pubmed.ncbi.nlm.nih.gov/42322532/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))
- Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/40464749/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))

## Why other serums fit combination skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Users with dry, mature, and sensitive skin frequently praise this serum for its ability to visibly plump fine lines and deliver a "glass-skin" radiance without irritation. Many report smoother texture and improved hydration, while a minority of users experienced breakouts or frustration with the packaging design.

- Liked: Elegant texture (often mentioned)
- Liked: Hydrating and plumping (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Great value (sometimes noted)
- Liked: Visible anti-aging (sometimes noted)
- Disliked: Poor pump design (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Runs out quickly (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does the Multi-Peptide Advanced Serum work for combination skin?

This serum works moderately well for combination skin because its antioxidants and hydration help smooth your skin, though it lacks enough oil-controlling ingredients for your oily areas. To work best for combination skin, a product of this type needs ingredients like niacinamide, propolis, and zinc PCA to regulate oiliness while keeping the skin balanced and hydrated.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for combination skin?

This serum works for combination skin because ferulic acid, glycerin, and squalane provide helpful antioxidants and hydration. To be a top fit for this skin type, a treatment needs ingredients like niacinamide, zinc PCA, or propolis to balance oily areas and regulate shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Peptides do for combination skin?

Peptides help combination skin by supporting firmness, smoothing out wrinkles, and improving hydration without feeling heavy. They work by encouraging collagen production, which may help keep the skin looking smooth and bouncy.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/), [International Journal of Molecular Medicine, 2017](https://pubmed.ncbi.nlm.nih.gov/27878236/)

### What does Ferulic Acid do for combination skin?

Ferulic acid helps protect combination skin from sun damage and everyday environmental stress while boosting the performance of vitamins C and E. For combination skin to get the best results, this ingredient needs to be paired with antioxidants and lightweight hydrators that balance oil and dry areas without clogging pores.
Sources: [Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/), [Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and before moisturizing. Combination skin of this type needs balancing ingredients like niacinamide or clay for oil control.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your skin hydration and anti-aging benefits, followed by your retinol. This product works for combination skin, though this skin type needs oil-controlling ingredients to manage shine best.

### How often should I use this serum?

You can use this treatment in your evening routine, as suggested for simplicity and extra safety around sun exposure. Combination skin needs products that also provide oil-controlling ingredients to manage shine on oily areas.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause irritation or breakouts on combination skin, as it contains soothing extracts and lacks harsh ingredients. However, because it fits combination skin only moderately, a product of this type needs extra oil-balancing ingredients to better manage shine on oily areas.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Augustinus Bader The Serum](https://lovi.care/skincare/ae/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — AED 1,348.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — AED 715.99 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/combination-skin) — Superior fit — AED 365.22 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ae/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — AED 145.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ae/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — AED 33.40 at Amazon

## Where to buy

- Amazon.ae: AED 98.82 (https://www.amazon.ae/dp/B0CQTSM65J?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Propanediol, Caprylic Capric Triglyceride, Isopentyldiol, Ethylhexyl Polyhydroxystearate, Squalane, Tetradecane, Glyceryl Stearate Citrate, Butyrospermum Parkii Butter Shea Butter, Polyglyceryl-3 Stearate, Helianthus Annuus Extract Sunflower Extract, Rice Bran Extract, Mannitol, Phosphatidylcholine, Ferulic Acid, Arginine, Acetyl Hexapeptide-8, Copper Palmitoyl Heptapeptide-14, Palmitoyl Sh-Hexapeptide-13 Serine Sp Amide, Hydrolyzed Collagen, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Lactic Acid Glycolic Acid Copolymer, Glycerin, Tocopherol, Pullulan, Lysolecithin, Sclerotium Gum, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Dimethicone, Sodium Phytate, Diglycerin, Hydrogenated Lecithin, Silica, Cetyl Alcohol, Hydroxyacetophenone, Polysorbate 60, Sorbitan Isostearate, Sodium Hydroxide, Sodium Benzoate, Potassium Sorbate, Polyvinyl Alcohol, Decyl Glucoside, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Citric Acid, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/naturium/multi-peptide-advanced-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/naturium/multi-peptide-advanced-serum/for/combination-skin (this page)