# Natura Bissé C+C Vitamin Complex for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Natura Bissé](https://lovi.care/skincare/ae/brands/natura-bisse)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate skin brightening for your combination skin due to Sodium Ascorbyl Phosphate, which helps even skin tone, while Glycerin provides hydration that is not optimal for oily shine.
- Hydrolyzed Collagen and Rosa Canina Oil Fruit offer general skincare benefits and hydration, but lack sufficient ingredients for effective oil control on your oily shine.
- The product is safe for your combination skin, with no risks of irritation from harsh ingredients and the inclusion of soothing agents like Tocopherol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/acne-prone-skin): Low
- [Skin with dark spots](https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin): Low

## Key ingredients

Ascorbic Acid, Vitamin E, Rosa Canina Oil Fruit, Hydrolyzed Collagen, Tocopherol

## What the research says

- Combined ascorbyl palmitate and sodium ascorbyl phosphate treatment significantly reduced facial sebum secretions in healthy female volunteers compared to a placebo control over 90 days. ([Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/))
- The tetrapeptide PKEK exerts skin whitening effects by reducing UVB-stimulated mRNA expression of pigmentation-inducing mediators like POMC and tyrosinase, and significantly fades facial pigment spots when combined with sodium ascorbyl phosphate. ([Experimental Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22142309/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- Topical treatments containing rosehip extract may reduce the size and erythema of postsurgical scars through macrophage polarization and inflammatory cytokine inhibition, though current clinical evidence remains insufficient to recommend its routine use. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37605366/))
- Sunflower and rosehip oil nanoemulsions prepared with a mix of phospholipids and synthetic emulsifiers permeated intact skin to the dermis and showed a more prominent healing effect in a human organotypic skin explant culture wound model compared to nanoemulsions prepared only with phospholipids. ([Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36986857/))
- A nanoemulsion containing 1 mg/mL kojic dipalmitate and 5% rosehip oil demonstrated high incorporation efficiency, suitable physicochemical stability, antioxidant and depigmenting efficacy close to 1 mM ascorbic acid, and no cytotoxicity at concentrations from 0.06% to 1% in vitro. ([Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36839792/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Based on limited data, users consistently praise this serum for its potent brightening abilities, noting that it effectively revitalizes dull, tired-looking skin and improves overall radiance. The lightweight, fast-absorbing texture is a hit, though some users with sensitive skin caution against potential irritation due to the high concentration of Vitamin C and strong citrus fragrance.

- Liked: Brightens dull skin (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Lightweight texture (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Potential irritation (sometimes noted)
- Liked: Firming effect (rarely noted)
- Disliked: Availability issues (rarely noted)
- Disliked: Strong fragrance (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Natura Bissé C+C Vitamin Complex work for combination skin?

Natura Bissé C+C Vitamin Complex is an average fit for combination skin because it offers moderate brightening and hydration, but it lacks sufficient ingredients for effective oil control. A treatment for this skin needs ingredients like niacinamide, propolis, or zinc PCA to provide balanced hydration and regulate oiliness without any risk of irritation.
Sources: [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/), [Experimental Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22142309/)

### Which ingredients make this treatment a good fit for combination skin?

Sodium Ascorbyl Phosphate helps even skin tone and reduce oily shine, while Glycerin provides light hydration. To truly fit combination skin, a treatment of this type needs ingredients like niacinamide and zinc PCA to properly balance oiliness and maintain skin health.
Sources: [Drug Research, 2017](https://pubmed.ncbi.nlm.nih.gov/27756097/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Vitamin C do for combination skin?

Vitamin C helps brighten dull areas and smooth out uneven texture on combination skin while protecting against daily environmental stress. It may also help keep pores clear and skin firm by supporting collagen production, though drier spots may need an added moisturizer to stay comfortable.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Vitamin E do for combination skin?

Vitamin E helps balance combination skin by boosting moisture while calming redness and reducing oiliness in shiny areas. It is generally well-tolerated and may help protect the skin barrier, keeping both dry and oily patches comfortable and smooth.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38268219/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32129554/)

### Where does this treatment go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing, though some treatments can also be used in the morning or twice a day. For combination skin, a product of this type needs ingredients that brighten skin while offering effective oil control.

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol by applying your retinol first and following with this treatment, or by using retinol at night and this treatment in the morning to avoid overloading your skin. This product helps brighten tone and provides hydration, but combination skin works best with products that also offer targeted oil control.

### How often should I use this treatment?

You can use this treatment in the evening as part of your routine for combination skin. To keep your skin balanced, a product of this type needs targeted oil-control ingredients and hydration that manages oily shine.

### Can this treatment clog pores, cause breakouts or purging for combination skin?

This treatment is unlikely to clog pores or cause breakouts on combination skin, as it has a safe profile with soothing ingredients like Tocopherol and no harsh irritants. However, to better manage oily shine, combination skin needs products with effective oil-control ingredients.

### Is this treatment fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, limonene, and linalool).

## Alternatives for combination skin

- [Augustinus Bader The Serum](https://lovi.care/skincare/ae/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — AED 1,348.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — AED 715.99 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/combination-skin) — Superior fit — AED 365.22 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ae/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — AED 145.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ae/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — AED 33.40 at Amazon

## Where to buy

- Amazon.ae: AED 361.07 (https://www.amazon.ae/dp/B0032Z3CDW?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Sodium Ascorbyl Phosphate, Sodium Acrylates Copolymer, Propanediol, Glycerin, Hydrogenated Polyisobutene, Rosa Canina Oil Fruit, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Citric Acid, Tocopheryl Acetate, Anogeissus Leiocarpus Bark Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Hydrolyzed Collagen, Sodium Chondroitin Sulfate, Prunus Amygdalus Dulcis Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Polysorbate 60, Sorbitan Stearate, Disodium Edta, Tocopherol, Potassium Sorbate, Phenoxyethanol, Parfum, Limonene, Linalool, Citrus Nobilis Oil Mandarin Orange Oil, Citrus Aurantium Dulcis Oil, Amyl Cinnamal, Yellow 5 Ci 19140
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- France: https://lovi.care/skincare/fr/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/natura-bisse/c-c-vitamin-complex/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/combination-skin (this page)