# MISSHA Time Revolution Night Repair Probio Ampoule for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [MISSHA](https://lovi.care/skincare/ae/brands/missha)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for combination skin as bifida ferment lysate and niacinamide enhance barrier resilience and regulate melanogenesis, though these ingredients do not specifically target oily shine concerns.
- Glycerin and panthenol provide general hydration and soothing benefits, which are supportive for your skin but not directly addressing your primary goal of reducing oily shine.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Sodium Hyaluronate, Probio Lactobacillus Complex, Panthenol

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35384257/))
- Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers. ([International Journal of Medical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/33526970/))
- Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials. ([Current Issues in Molecular Biology, 2022](https://pubmed.ncbi.nlm.nih.gov/35723322/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

This ampoule is frequently praised for delivering a 'glass skin' effect overnight, making dry and mature skin appear plump, hydrated, and glowing. A very large amount of data suggests that while it's a highly effective and affordable alternative to luxury serums, the high concentration of fermented ingredients may cause breakouts in individuals with fungal acne or sensitivities.

- Liked: Instant Glow (mostly mentioned)
- Liked: Deep Hydration (often mentioned)
- Liked: Lightweight Texture (often mentioned)
- Liked: Texture Improvement (sometimes noted)
- Liked: Value for Money (sometimes noted)
- Disliked: Breakouts & Reactions (sometimes noted)
- Disliked: Fragrance & Oils (sometimes noted)
- Disliked: Dropper Issues (rarely noted)
- Disliked: Ineffective for Some (rarely noted)
- Disliked: Sticky Residue (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does MISSHA Night Repair Probio Ampoule work for combination skin?

This ampoule offers moderate suitability for combination skin because its ingredients strengthen the skin barrier and provide soothing hydration, though it does not directly target oily shine. To work best for this skin type, a treatment needs ingredients like niacinamide and zinc PCA that manage oily shine while providing balanced hydration without overwhelming oilier areas.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this serum a good fit for combination skin?

Bifida lysate ferment and niacinamide make this serum a fit by strengthening your skin barrier, while glycerin and panthenol provide gentle hydration. To work best for combination skin, a treatment of this type needs ingredients like niacinamide, propolis, or zinc PCA that actively balance oiliness and reduce oily shine without causing irritation.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Bifida Ferment Lysate do for combination skin?

Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, making it a good fit for combination skin that is prone to sensitivity. This ingredient works by supporting the skin defenses, keeping moisture locked in, and helping to reduce redness.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after your cleansing toner and before your moisturizer. Combination skin products of this type also need ingredients that target oily shine.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying it after your retinol step to help soothe your skin. Combination skin of this type needs lightweight hydrators and ingredients that control excess oil and shine while supporting the skin barrier.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this serum?

You can use this treatment in the evening as part of your nighttime routine. Combination skin needs ingredients that specifically target oily shine alongside hydration and barrier support.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum may occasionally cause breakouts or reactions for some people with combination skin, as reviewers moderately complain about these issues. However, the product is generally safe for your skin type with no harsh ingredients.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Augustinus Bader The Serum](https://lovi.care/skincare/ae/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — AED 1,348.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — AED 715.99 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/combination-skin) — Superior fit — AED 365.22 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ae/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — AED 145.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ae/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — AED 33.40 at Amazon

## Where to buy

- Amazon.ae: AED 119.94 (https://www.amazon.ae/dp/B09648RPKJ?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Butylene Glycol, Glycerin, Propanediol, Betaine, Water, Niacinamide, Pentylene Glycol, 1,2-Hexanediol, Diethoxyethyl Succinate, Chondrus Crispus Extract, Squalane, Panthenol, Polyglyceryl-10 Laurate, Saccharum Officinarum Extract, Hydrogenated Lecithin, Carbomer, Tromethamine, Xanthan Gum, Polyquaternium-51, Ethylhexylglycerin, Adenosine, Dextrin, Theobroma Cacao Extract, Beta Vulgaris Root Extract, Brassica Oleracea Capitata Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Solanum Melongena Fruit Extract, Blueberry Fruit Extract, Bergamot Oil Fruit, Disodium Edta, Sodium Hyaluronate, Lactobacillus Soybean Extract Ferment, Leuconostoc Radish Root Ferment Filtrate, Bifida Ferment Filtrate, Lactobacillus Ferment, Lactobacillus Lysate Ferment, Lactobacillus Acerola Cherry Ferment, Lactobacillus Punica Granatum Extract Fruit Ferment, Pelargonium Graveolens Oil Flower, Helianthus Annuus Seed Oil Sunflower Seed Oil, Citrus Aurantium Dulcis Peel Oil, Lavandula Angustifolia Oil Lavender Oil, Lupinus Albus Seed Extract, Aspergillus Ferment, Swiftlet Nest Extract, Anthemis Nobilis Oil Flower, Sandalwood Oil, Tocopherol, Ceramide Np, Cholesterol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- France: https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-probio-ampoule/for/combination-skin (this page)