# Medik8 Liquid Peptides for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Medik8](https://lovi.care/skincare/ae/brands/medik8)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate plumping for your combination skin, as Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1 work to improve volume and elasticity, while Glycerin and Hyaluronic Acid provide essential hydration without exacerbating oiliness.
- The formula supports general skincare benefits and hydration, which is helpful for managing oily shine, but it lacks specific ingredients to directly target oil control.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/oily-acne-prone-skin): Average

## Key ingredients

Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Users consistently praise this serum as a "Botox in a bottle" alternative that delivers immediate hydration and visible plumping, particularly for fine lines on the forehead and around the eyes. It is widely celebrated for its ability to smooth skin texture and restore bounce to dry or mature skin without causing irritation, making it a staple for those targeting early to advanced signs of aging.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Elegant, lightweight texture (often mentioned)
- Liked: Visibly plumps and smooths (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Disliked: Packaging fragility (sometimes noted)
- Disliked: Results require patience (rarely noted)
- Disliked: Slight tackiness (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medik8 Liquid Peptides serum work for combination skin?

Medik8 Liquid Peptides works moderately well for combination skin, offering basic hydration and smoothing without making oily areas worse. However, because it lacks targeted oil control ingredients, combination skin needs a treatment that includes niacinamide, zinc PCA, or propolis to properly balance oil and enhance radiance.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Which ingredients make this serum a good fit for combination skin?

Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1 make this serum a good fit for your combination skin by improving volume and elasticity, while glycerin and hyaluronic acid provide essential hydration without making oily areas worse. To fit combination skin even better, this type of product needs ingredients like niacinamide, zinc PCA, or propolis to help control oily shine and boost radiance.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### What does Argireline do for combination skin?

Argireline helps smooth out lines and keeps combination skin feeling soft when applied twice daily. This ingredient may reduce wrinkle depth and improve overall skin texture, though its absorption through the skin is quite low.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Palmitoyl Tripeptide-1 do for combination skin?

Palmitoyl tripeptide-1 helps smooth fine lines and supports firmness in combination skin when used as part of an anti-aging routine. Studies show that ingredients like this peptide can improve overall skin texture and boost collagen levels when applied consistently over time.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### Where does this serum go in a skincare routine for combination skin?

This treatment serum goes in your evening routine after cleansing and toning, and before moisturizing. Combination skin products of this type also need ingredients for direct oil control to manage shine.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the retinol first, letting it absorb, and then following with this treatment to keep your skin hydrated. This product is unlikely to irritate your skin since it has no harsh ingredients, but combination skin also needs specific oil-control ingredients to properly manage shine.

### How often should I use this serum?

This treatment fits into your evening routine as an average match for combination skin, providing helpful hydration without making oily areas worse. To work best for this skin type, a product of this kind needs added oil-controlling ingredients to manage shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

Medik8 Liquid Peptides is unlikely to cause breakouts or clog pores on combination skin, as it has a very safe formula without harsh ingredients that lead to irritation. However, because this type of skin can be prone to shine, a product for it needs extra oil-controlling ingredients to manage oil properly.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Augustinus Bader The Serum](https://lovi.care/skincare/ae/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — AED 1,348.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — AED 715.99 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/combination-skin) — Superior fit — AED 365.22 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ae/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — AED 145.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ae/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — AED 33.40 at Amazon

## Where to buy

- Amazon.ae: AED 469.66 (https://www.amazon.ae/dp/B0DYV9VSDV?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: AED 411.00 (https://www.lookfantastic.ae/p/medik8-liquid-peptides-advanced-mp-30ml/15826874/)
Prices checked 17 Oct – 1 Nov 2026.

## Ingredients

Water, Glycerin, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Hyaluronic Acid, Lecithin, Caprylyl Glycol, Disodium Edta, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medik8/liquid-peptides/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medik8/liquid-peptides/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/medik8/liquid-peptides/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/medik8/liquid-peptides/for/combination-skin
- France: https://lovi.care/skincare/fr/p/medik8/liquid-peptides/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/medik8/liquid-peptides/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/medik8/liquid-peptides/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/medik8/liquid-peptides/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/medik8/liquid-peptides/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/medik8/liquid-peptides/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/medik8/liquid-peptides/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medik8/liquid-peptides/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/combination-skin (this page)