# Medicube Zero Exosome Shot for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Medicube](https://lovi.care/skincare/ae/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily skin; a few serums fit it even better.

## Why this fit

- Offers excellent suitability for your oily skin, as niacinamide helps regulate sebum and betaine salicylate provides keratolytic action to manage oiliness and shine.
- The formula also contains panthenol and various botanical extracts that offer soothing and hydrating benefits, complementing the primary active ingredients.
- The product is safe for your skin, with no reported risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/oily-acne-prone-skin): High

## Key ingredients

Lacto Exosome, Niacinamide, Betaine Salicylate, Adenosine, Hydrolyzed Sponge

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Lactobacillus-derived exosome therapy combined with microneedling reduced acne severity, post-inflammatory hyperpigmentation, and atrophic scarring in three patients, with high satisfaction and minimal adverse effects. ([The Journal of Craniofacial Surgery, 2025](https://pubmed.ncbi.nlm.nih.gov/40257450/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- A nano-encapsulated spicule system delivering Wharton's Jelly MSC secretome enhanced transdermal penetration, promoted cell proliferation and collagen synthesis in vitro, and reduced wrinkles and pigmentation in clinical evaluation. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41155317/))
- Deer antler velvet extract formulated in sponge spicule micro-blend cream applied to healthy humans for 14 days enhanced macromolecule skin permeation by 1.94-fold, decreased melanin content and erythema, and increased skin elasticity and hydration without causing irritation. ([Biological & Pharmaceutical Bulletin, 2019](https://pubmed.ncbi.nlm.nih.gov/31257296/))
- Marine sponge spicules enhanced the skin delivery of human umbilical cord-derived mesenchymal stem cell exosomes by a factor of 5.87 and combined with them produced significant anti-photoaging effects in mice compared to exosomes alone. ([International Journal of Nanomedicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32368058/))

## What reviewers say

Users describe this ampoule as a potent texturizing treatment that delivers a glass skin finish by minimizing pores and smoothing roughness. While highly effective for many in tightening pores and boosting radiance, the sensation is polarizing, often described as a prickly or tingling feeling that can be intense for sensitive skin.

- Liked: Smoother texture (mostly mentioned)
- Disliked: Prickly sensation (mostly mentioned)
- Liked: Pore minimization (often mentioned)
- Liked: Radiance and glow (often mentioned)
- Liked: Enhanced absorption (sometimes noted)
- Disliked: Skin irritation (sometimes noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Unpleasant texture (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Zero Exosome Shot a great fit for oily skin?

This treatment is a great fit because niacinamide helps regulate sebum and betaine salicylate helps manage excess oil and shine. Panthenol and plant extracts also provide soothing and hydrating benefits to keep your skin calm and comfortable.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for oily skin?

Niacinamide and betaine salicylate make this serum a great fit for oily skin because niacinamide helps regulate sebum and betaine salicylate clears away dead skin to manage excess oiliness and shine. The formula also includes panthenol to help keep your skin calm and hydrated without irritation.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Lacto Exosome do for oily skin?

Lacto Exosome helps strengthen your skin barrier by boosting key proteins that keep your skin healthy and balanced. This ingredient is unlikely to clog pores and may improve overall skin texture, though oily skin also benefits from ingredients that gently clear pores and balance oil production.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40356846/)

### What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for oily skin?

Apply this treatment in the evening after cleansing and toning, and follow it with a moisturizer. Treatments with active ingredients go in the evening routine for simplicity and extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol, but it is best to use them on alternate nights or separate them into your morning and evening routines to avoid overloading your skin. Panthenol in the formula helps soothe the skin, while niacinamide and betaine salicylate manage oiliness, making it a supportive addition to an active routine.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### How often should I use this serum?

Start by using this treatment once a week in your evening routine, and carefully use it more often if your skin handles it well and shows good results. The formula is safe for your skin, with no reported risks of irritation.

### Can this serum clog pores, cause breakouts or purging for oily skin?

This treatment is a great fit for oily skin because niacinamide helps regulate oil and betaine salicylate helps clear pores. The formula is unlikely to cause issues, though a prickly sensation is commonly reported by reviewers.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/oily-skin) — Superior fit — AED 365.22 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — AED 715.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vita-c-serum/for/oily-skin) — High fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ae/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — AED 49.95 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ae/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — AED 49.99 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ae/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — AED 33.40 at Amazon

## Where to buy

- Amazon.ae: AED 36.99 (https://www.amazon.ae/dp/B0D137TMRB?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 30 Oct 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, Hydrolyzed Sponge, C12-14 Alketh-12, Hydrogenated Polydecene, Ethylhexylglycerin, Adenosine, Caprylyl Capryl Glucoside, Disodium Edta, Panthenol, Calcium Silicate, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis Flower Extract, Ulmus Davidiana Root Extract, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-exosome-shot/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-exosome-shot/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-exosome-shot/for/oily-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-exosome-shot/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-exosome-shot/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-exosome-shot/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-exosome-shot/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-exosome-shot/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-exosome-shot/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-exosome-shot/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/oily-skin (this page)