# Medicube Zero Exosome Shot for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Medicube](https://lovi.care/skincare/ae/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, this product effectively addresses oily shine with niacinamide for seboregulation and betaine salicylate for mild exfoliation and pore refinement.
- Panthenol and adenosine further support skin health by providing hydration and improving skin elasticity, complementing the primary active ingredients.
- The formulation is safe for your skin, containing no harsh or prohibited ingredients that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/oily-acne-prone-skin): High

## Key ingredients

Lacto Exosome, Niacinamide, Betaine Salicylate, Adenosine, Hydrolyzed Sponge

## What the research says

- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Lactobacillus-derived exosome therapy combined with microneedling reduced acne severity, post-inflammatory hyperpigmentation, and atrophic scarring in three patients, with high satisfaction and minimal adverse effects. ([The Journal of Craniofacial Surgery, 2025](https://pubmed.ncbi.nlm.nih.gov/40257450/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- A nano-encapsulated spicule system delivering Wharton's Jelly MSC secretome enhanced transdermal penetration, promoted cell proliferation and collagen synthesis in vitro, and reduced wrinkles and pigmentation in clinical evaluation. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41155317/))
- Deer antler velvet extract formulated in sponge spicule micro-blend cream applied to healthy humans for 14 days enhanced macromolecule skin permeation by 1.94-fold, decreased melanin content and erythema, and increased skin elasticity and hydration without causing irritation. ([Biological & Pharmaceutical Bulletin, 2019](https://pubmed.ncbi.nlm.nih.gov/31257296/))
- Marine sponge spicules enhanced the skin delivery of human umbilical cord-derived mesenchymal stem cell exosomes by a factor of 5.87 and combined with them produced significant anti-photoaging effects in mice compared to exosomes alone. ([International Journal of Nanomedicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32368058/))

## What reviewers say

Users describe this ampoule as a potent texturizing treatment that delivers a glass skin finish by minimizing pores and smoothing roughness. While highly effective for many in tightening pores and boosting radiance, the sensation is polarizing, often described as a prickly or tingling feeling that can be intense for sensitive skin.

- Liked: Smoother texture (mostly mentioned)
- Disliked: Prickly sensation (mostly mentioned)
- Liked: Pore minimization (often mentioned)
- Liked: Radiance and glow (often mentioned)
- Liked: Enhanced absorption (sometimes noted)
- Disliked: Skin irritation (sometimes noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Unpleasant texture (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes MEDICUBE Zero Exosome Shot a great fit for combination skin?

This product is a great fit for your combination skin because it helps control oily shine with niacinamide and gently smooths pores with betaine salicylate. Panthenol and adenosine also support your skin's health by providing hydration and improving elasticity, while the safe formula is unlikely to cause irritation.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this treatment a good fit for combination skin?

This treatment is a great fit for combination skin because niacinamide helps control oily shine while betaine salicylate provides mild exfoliation to refine pores. Panthenol and adenosine also support skin health by boosting hydration and elasticity.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Lacto Exosome do for combination skin?

Lacto Exosome helps strengthen the skin barrier by boosting key proteins that keep dry and oily areas balanced and hydrated. This ingredient is unlikely to cause irritation and may improve overall skin resilience.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40356846/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this treatment go in a skincare routine for combination skin?

This treatment goes in your evening routine, applied after cleansing and before moisturizing. Lovi places treatments in the evening for simplicity and extra safety around sun exposure.

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol, but it is best to apply them on alternate nights or separate them into different routines to avoid irritation. This product contains active exfoliants like betaine salicylate, so using it on the same night as retinol may make dry or sensitive skin more prone to redness.

### How often should I use this treatment?

Start using this treatment once a week in the evening, and if your combination skin handles it well, you can carefully use it more often. The product is a great fit because niacinamide and betaine salicylate help control oily shine and refine pores, while panthenol and adenosine support skin hydration and elasticity.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/)

### Can this treatment clog pores, cause breakouts or purging for combination skin?

This treatment is unlikely to clog pores or cause breakouts on combination skin, as it contains niacinamide and mild exfoliants that help manage oily shine and refine pores. Panthenol and adenosine also support skin health by keeping it hydrated, though you may feel a prickly sensation from the active ingredients.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Augustinus Bader The Serum](https://lovi.care/skincare/ae/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — AED 1,348.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — AED 715.99 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/combination-skin) — Superior fit — AED 365.22 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ae/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — AED 145.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ae/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — AED 33.40 at Amazon

## Where to buy

- Amazon.ae: AED 36.99 (https://www.amazon.ae/dp/B0D137TMRB?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 30 Oct 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, Hydrolyzed Sponge, C12-14 Alketh-12, Hydrogenated Polydecene, Ethylhexylglycerin, Adenosine, Caprylyl Capryl Glucoside, Disodium Edta, Panthenol, Calcium Silicate, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis Flower Extract, Ulmus Davidiana Root Extract, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-exosome-shot/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-exosome-shot/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-exosome-shot/for/combination-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-exosome-shot/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-exosome-shot/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-exosome-shot/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-exosome-shot/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-exosome-shot/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-exosome-shot/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-exosome-shot/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/combination-skin (this page)