# Medicube Triple Collagen Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Medicube](https://lovi.care/skincare/ae/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin, this serum effectively addresses wrinkles and fine lines with collagen extracts and adenosine, which support collagen production and improve skin elasticity. Glycerin and hyaluronic acid derivatives further enhance hydration and barrier repair, complementing your skin's natural balance.
- The inclusion of niacinamide offers additional benefits for skin tone and texture, contributing to a smoother, more radiant complexion.
- This formula is safe for your skin, as it contains no harsh ingredients and includes soothing components like glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Triple Collagen Complex, Sodium Hyaluronate, Niacinamide, Collagen Extract, Adenosine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

Users frequently report this serum provides deep hydration, leading to a plumped, radiant complexion often described as 'glass skin'. It is well-loved for its smooth, non-greasy texture and effectiveness in diminishing fine lines, making it a great base for makeup. Some users find the fragrance to be strong and occasionally encounter issues with the packaging.

- Liked: Deep hydration (mostly mentioned)
- Liked: Glow and radiance (often mentioned)
- Liked: Good texture (sometimes noted)
- Liked: Plumping and anti-aging (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Strong fragrance (sometimes noted)
- Liked: Makeup compatibility (rarely noted)
- Disliked: Skin sensitivity (rarely noted)
- Disliked: Slightly sticky (rarely noted)
- Disliked: Small quantity (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medicube Triple Collagen Serum a great fit for mature skin?

This serum is a great fit because it uses collagen extracts and adenosine to target fine lines and help improve skin elasticity. Hyaluronic acid and glycerin also deeply hydrate the skin while supporting barrier repair, and niacinamide helps create a smoother, more radiant complexion.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit because collagen extracts and adenosine help smooth wrinkles and improve skin elasticity. Glycerin and hyaluronic acid derivatives boost moisture and strengthen the skin barrier, while niacinamide gives you a more radiant and even complexion.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/)

### What does Triple Collagen do for mature skin?

Triple Collagen helps improve wrinkles, dryness, and elasticity in mature skin. Clinical studies show that regular use of collagen peptides helps keep skin firm and deeply hydrated.
Sources: [Journal of Microbiology and Biotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40935395/), [Journal of Clinical Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/39336856/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does it go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Putting treatments in the evening provides extra safety around sun exposure and keeps your routine simple.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your skin a boost of hydration, followed by retinol once it absorbs. This routine helps keep your skin smooth and comfortable while working on fine lines.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/)

### How often should I use it?

Apply this serum in your evening routine for simplicity and safety around sun exposure. It is safe for daily use to help smooth fine lines and boost hydration on mature skin.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains no harsh ingredients and features soothing components. It helps keep skin smooth and hydrated without triggering unwanted reactions.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Is it fragrance-free and alcohol-free?

It contains fragrance (linalool and limonene) and drying alcohol (alcohol denat).

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — AED 347.75 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — AED 715.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ae/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — AED 65.43 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/ae/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — AED 493.00 at Amazon

## Where to buy

- Amazon.ae: AED 44.68 (https://www.amazon.ae/dp/B0D1G8MZMF?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, Niacinamide, Glycereth-26, Alcohol Denat, 1,2-Hexanediol, Trehalose, Carbomer, Cetearyl Olivate, Tromethamine, Sorbitan Olivate, Ethylhexylglycerin, Collagen Extract, Adenosine, Disodium Edta, Atelocollagen, Desamido Collagen, Hydrolyzed Collagen, Sodium Hyaluronate, Water-Soluble Collagen, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Collagen, Collagen Amino Acids, Sodium Acetylated Hyaluronate, Procollagen, Cyclopentasiloxane, Hydroxypropyltrimonium Hyaluronate, Cyclohexasiloxane, Dimethicone, Benzyl Benzoate, Linalool, Limonene
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/triple-collagen-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/triple-collagen-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/triple-collagen-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/triple-collagen-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medicube/triple-collagen-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/triple-collagen-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medicube/triple-collagen-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/triple-collagen-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/mature-skin (this page)