# Medicube One Day Exosome Shot 7500 for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Medicube](https://lovi.care/skincare/ae/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate exfoliation and hydration for your combination skin, with niacinamide helping to regulate oil and betaine salicylate providing mild exfoliation, though these are not specifically targeted for your acne concerns.
- Glycerin and panthenol offer general skincare benefits and hydration, which are supportive for your skin's overall health.
- The product is generally safe for your combination skin, with a low risk of irritation from betaine salicylate and citric acid.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin): Average

## Key ingredients

Lactobacillus Extracellular Vesicles, Niacinamide, Adenosine, Betaine Salicylate, Oenothera Biennis Flower Extract

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/))
- A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris. ([Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models. ([Metabolites, 2021](https://pubmed.ncbi.nlm.nih.gov/34436468/))

## Why other serums fit acne-prone skin better

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Users frequently report a "glass skin" effect with noticeable improvements in skin texture and pore size after overnight use, though the application involves a distinct prickly sensation due to the spicules. While highly effective for smoothing and tightening, it is polarizing due to the "needle-like" pain and potential for irritation on sensitive skin.

- Liked: Smoother skin texture (mostly mentioned)
- Disliked: Painful application (mostly mentioned)
- Liked: Fast/overnight results (often mentioned)
- Liked: Visible pore reduction (often mentioned)
- Liked: Enhanced product absorption (sometimes noted)
- Disliked: Not for sensitive skin (sometimes noted)
- Disliked: Skin irritation (sometimes noted)
- Disliked: High price point (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medicube Exosome Shot 7500 work for acne-prone skin?

This treatment works moderately well for acne-prone skin, providing mild exfoliation and hydration with a low risk of irritation, though other products fit your skin better. Treatments that fit this skin better need ingredients like niacinamide and propolis or zinc PCA for breakouts, along with antioxidants and hydrating agents that balance oil and keep skin clear without causing irritation.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for acne-prone skin?

Niacinamide and betaine salicylate help make this serum an average fit for acne-prone skin by regulating oil and providing mild exfoliation, though it lacks specific blemish-fighting ingredients. An ideal product for this skin needs effective ingredients like niacinamide, propolis, or zinc PCA that target breakouts and control oil without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/)

### What do Lactobacillus Extracellular Vesicles do for acne-prone skin?

Lactobacillus extracellular vesicles may help calm acne-prone skin by reducing irritation and supporting the skin barrier. Because acne-prone skin needs to balance oil while avoiding inflammation, this type of product works best when it includes soothing agents and lightweight, non-clogging hydrators.
Sources: [Frontiers in Immunology, 2026](https://pubmed.ncbi.nlm.nih.gov/42643438/), [International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41175997/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does it go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine. Acne-prone skin needs a product with targeted blemish-fighting ingredients and oil-balancing actives designed specifically for breakouts.

### Can I use this serum with retinol, and in what order?

This treatment should not be used in the same routine as retinol, as layering both may lead to excessive irritation and discomfort on your skin. Instead, you can alternate them on different nights or use retinol at night and this product during the day.

### How often should I use it?

Start by using this treatment once a week in the evening, and if your skin feels comfortable and handles it well, you may carefully use it more often. To properly care for acne-prone skin, a product of this type needs targeted blemish-fighting ingredients and oil-balancing actives that specifically address breakouts.

### Can it clog pores, cause breakouts or purging for acne-prone skin?

This treatment is unlikely to clog pores or cause breakouts for acne-prone skin, though it offers only moderate exfoliation and hydration rather than targeted acne care. To truly clear and balance acne-prone skin, a product needs dedicated breakout-fighting ingredients and oil-balancing care that directly address blemishes.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/acne-prone-skin) — Superior fit — AED 365.22 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — AED 715.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ae/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — AED 49.95 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ae/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — AED 49.99 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/ae/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — AED 91.81 at Amazon

## Where to buy

- Amazon.ae: AED 35.80 (https://www.amazon.ae/dp/B0D137TMRB?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin (this page)