# Mary Kay Timewise Night Solution for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Mary Kay](https://lovi.care/skincare/ae/brands/mary-kay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ae/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other moisturizers fit it better.

## Why this fit

- Suitable for normal skin, this formulation contains Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 to support collagen stimulation and extracellular matrix synthesis, offering general moisturizing and anti-aging benefits.
- While Glycerin provides hydration, the product lacks specialized ingredients to effectively target your goal of addressing wrinkles and fine lines.
- The safety profile is excellent, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/oily-acne-prone-skin): Average

## Key ingredients

Palmitoyl Tripeptide-1, Retinyl Palmitate, Tocopheryl Acetate, Glycerin, Crithmum Maritimum Extract

## What the research says

- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Retinyl palmitate ethosomal hydrogel reduced non-inflammatory and total acne lesion counts significantly better than marketed tretinoin while improving tolerability with minimal skin irritation in patients with acne vulgaris. ([International Journal of Nanomedicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34211271/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Preconditioning with samphire cell biomass formulations significantly accelerated epidermal permeability barrier repair kinetics after controlled stripping in healthy subjects older than 50 years compared to placebo and untreated sites. ([Journal of Cosmetic Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22151937/))
- Extracellular vesicles derived from Crithmum maritimum callus and miR167 promote wound healing and skin regeneration in human fibroblasts by downregulating MMP1 and upregulating COL1A1 and VEGFA without cytotoxicity. ([Biomolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40867601/))
- The full-component extract of Crithmum maritimum significantly promotes epidermal regeneration of UV-induced skin damage in a barrier-weakening 3D full-skin model compared to oil-based extract components. ([RSC Advances, 2025](https://pubmed.ncbi.nlm.nih.gov/39835209/))

## Why other moisturizers fit mature skin better

- Daily consumption of fermented pomegranate extract drinks and serums improved skin moisture, brightness, elasticity, and collagen density while reducing spots in healthy subjects compared to baseline. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34416060/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Timewise Night Solution work for mature skin?

Mary Kay Timewise Night Solution works for mature skin, though other products fit it better because it lacks specialized ingredients to effectively target wrinkles and fine lines. It is safe for this skin type and helps moisturize, yet a product for mature skin needs dedicated anti-wrinkle ingredients like peptides and retinoids to smooth and firm.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### Which ingredients make this serum a good fit for mature skin?

Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, and Retinyl Palmitate help support collagen and smooth the skin. To better fit mature skin, this type of product also needs specialized active ingredients that effectively target wrinkles and fine lines.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### What does Palmitoyl Tripeptide-1 do for mature skin?

Palmitoyl tripeptide-1 helps improve firmness, smooths out wrinkles, and enhances skin brightness when used as part of an anti-aging routine. Studies show that when applied at night or combined with complementary peptides, it supports collagen production to make mature skin look more firm and elastic.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### What does Retinyl Palmitate do for mature skin?

Retinyl palmitate helps smooth out fine lines and wrinkles on mature skin while improving overall firmness, texture, and dryness. It may also help protect against sun-induced aging by supporting skin structure and reducing collagen breakdown.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/), [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and toning, followed by your moisturizer. It is very gentle and is unlikely to cause any irritation.

### Can I use this serum with niacinamide, and in what order?

You can use this treatment with niacinamide by applying niacinamide first and following with this treatment once it absorbs. This product is generally safe and unlikely to cause irritation.

### How often should I use this serum?

Apply this treatment in your evening routine, as treatments fit best then for simplicity and extra safety around sun exposure. A product of this type for mature skin needs strong ingredients like concentrated retinol or advanced peptides to effectively smooth fine lines and wrinkles.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This product is unlikely to clog pores or cause breakouts on mature skin, as it has a very safe formula with no harsh or irritating ingredients. To properly smooth out wrinkles and fine lines, mature skin needs targeted ingredients like potent retinoids and specialized firming peptides alongside rich hydrators.
Sources: [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### Can I use this serum around the eyes or on my body?

This treatment is safe to use around the eyes or on the body because it has a very gentle formula with no harsh ingredients. Mature skin needs products rich in specialized peptides, strong antioxidants, and deep hydrators like hyaluronic acid to effectively smooth lines and firm the thin skin in these areas.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/ae/p/revision-skincare/hydrating-serum/for/mature-skin) — High fit — AED 333.85 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/ae/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/mature-skin) — High fit — AED 92.81 at Amazon
- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/ae/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/mature-skin) — High fit — AED 53.01 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ae/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — AED 65.43 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/ae/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — AED 39.45 at Amazon

## Where to buy

No store in United Arab Emirates has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Glycerin, 1-Methylhydantoin-2-Imide, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Tocopheryl Acetate, Retinyl Palmitate, Ascorbyl Palmitate, Crithmum Maritimum Extract, Geranium Extract, Mentha Arvensis Leaf Extract, Anthemis Nobilis Flower Extract, Rosa Centifolia Flower Extract, Citrus Aurantium Dulcis Flower Extract, Jasmine Extract, Ferula Galbaniflua Extract Gum, Cananga Odorata Flower Extract, Ribes Nigrum Fruit Extract Black Current Fruit Extract, Propylene Glycol, Hydroxyethylcellulose, Mannitol, Acrylates Vinyl Isodecanoate Crosspolymer, Cellulose, Hydroxypropyl Methylcellulose, Triethyl Citrate, Acrylates Ammonium Methacrylate Copolymer, Polysorbate 20, Carbomer, Triethanolamine, Disodium Edta, Talc, Methylparaben, Dmdm Hydantoin, Mica, Titanium Dioxide, Ultramarines, Red 30
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mary-kay/timewise-night-solution/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/mary-kay/timewise-night-solution/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/mary-kay/timewise-night-solution/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/mary-kay/timewise-night-solution/for/mature-skin
- France: https://lovi.care/skincare/fr/p/mary-kay/timewise-night-solution/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/mary-kay/timewise-night-solution/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/mary-kay/timewise-night-solution/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/mary-kay/timewise-night-solution/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/mary-kay/timewise-night-solution/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/mary-kay/timewise-night-solution/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/mary-kay/timewise-night-solution/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mary-kay/timewise-night-solution/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mary-kay/timewise-night-solution/for/mature-skin (this page)