# Manyo Factory Bifida Biome Complex Ampoule for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Manyo Factory](https://lovi.care/skincare/ae/brands/manyo-factory)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your redness and irritation due to Bifida Lysate Ferment and Asiaticoside, which support barrier repair and soothe inflammation, making it suitable for your normal, sensitive skin.
- The inclusion of Glycerin and multiple forms of Hyaluronic Acid provides essential hydration, further enhancing skin comfort and resilience.
- The product is safe for your sensitive skin, as it contains no harsh ingredients and includes soothing components like Bifida Lysate Ferment and Niacinamide.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Copper Tripeptide-1, Sodium Hyaluronate, Acetyl Hexapeptide-8

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## What reviewers say

Based on a very large amount of data, users widely praise this ampoule for its ability to strengthen the skin barrier and provide deep hydration without feeling heavy. Many report achieving a healthy, radiant glow and appreciate its lightweight, fast-absorbing texture, with some finding it soothing for redness and irritation. A small number of users experienced breakouts, and some felt the watery consistency was not moisturizing enough on its own or that the results did not justify the price.

- Liked: Strengthens barrier (mostly mentioned)
- Liked: Hydration and glow (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Soothing and calming (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Price vs. value (rarely noted)
- Disliked: Too watery (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Manyo Factory Bifida Biome Complex Ampoule work for sensitive skin?

This ampoule is an average fit for sensitive skin, offering moderate benefits for redness and irritation while helping to calm the skin and provide essential hydration. A treatment for sensitive skin needs soothing ingredients like niacinamide and Centella asiatica to support barrier repair without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for sensitive skin?

Bifida Lysate Ferment and Asiaticoside make this serum a good fit because they help calm redness and soothe irritation for sensitive skin. Glycerin and hyaluronic acid also provide essential hydration to keep the skin comfortable and resilient. To fit sensitive skin even better, a treatment of this type needs ingredients that offer stronger soothing and barrier-repairing benefits while completely avoiding any potential irritants.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Bifida Ferment Lysate do for sensitive skin?

Bifida Ferment Lysate helps calm reactive skin, making it less sensitive and more resistant to daily irritation and physical or chemical aggression. It achieves this by strengthening your skin barrier and keeping moisture locked in while decreasing redness.
Sources: [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/), [Scientific Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37803101/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your soothing toner and before your moisturizer. Treatments for sensitive skin need calming ingredients like bifida ferment lysate, niacinamide, and soothing plant extracts to help reduce redness and calm irritation.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment after your retinol to keep your sensitive skin comfortable and hydrated. This type of skin needs soothing ingredients like Bifida Lysate Ferment and hydrating components like glycerin and hyaluronic acid to calm redness and support barrier repair.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

This serum works well in your evening routine, and while it may be used once a day, sensitive skin often does best when starting just a few evenings a week to build comfort. To truly thrive, sensitive skin needs gentle, fragrance-free hydration and barrier-repairing ingredients like hyaluronic acid, ceramides, and centella extract.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores, but a small number of shoppers report that it may cause breakouts. A product of this type needs lightweight hydrators and calming ingredients like glycerin, hyaluronic acid, and centella asiatica to keep sensitive skin clear and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — AED 347.75 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — AED 715.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — AED 84.53 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ae/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — AED 81.41 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/ae/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — AED 65.10 at Amazon

## Where to buy

- Amazon.ae: AED 98.04 (https://www.amazon.ae/dp/B08DTTL17D?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Butylene Glycol, Bifida Ferment Filtrate, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Saccharomyces Ferment Filtrate, Glycerin, Niacinamide, 1,2-Hexanediol, Lactobacillus Pumpkin Fruit Ferment Filtrate, Aureobasidium Pullulans Ferment, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Leontopodium Alpinum Callus Culture Extract, Cutibacterium Granulosum Extract Ferment Filtrate, Asiaticoside, Asiatic Acid, Madecassic Acid, Pentylene Glycol, Squalane, Hydrogenated Lecithin, Copper Tripeptide-1, Tromethamine, Acetyl Hexapeptide-8, Propanediol, Ethylhexylglycerin, Dextrin, Water, Caffeine, Benzyl Glycol, Sodium Phytate, Hydrolyzed Algin, Xanthan Gum, Epigallocatechin Gallate, Carbomer, Physalis Alkekengi Calyx Extract, Hydrolyzed Glycosaminoglycans, Polyglyceryl-10 Laurate, Theobroma Cacao Seed Extract, Adenosine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/manyo-factory/bifida-biome-complex-ampoule/for/sensitive-skin (this page)