# ma:nyo Bifida Biome Complex Ampoule for oily skin

**Lovi Fit: Average fit for oily skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [ma:nyo](https://lovi.care/skincare/ae/brands/ma-nyo)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your oily skin, as Bifida Lysate Ferment and niacinamide help strengthen the skin barrier and regulate oil production, though it does not directly address concerns like oily shine.
- Multiple forms of hyaluronic acid and glycerin provide excellent hydration and plumping effects, supporting overall skin health and resilience.
- The product is safe for your oily skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin): Average (this page)
- [Dry skin](https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Sodium Hyaluronate, Copper Tripeptide-1, Acetyl Hexapeptide-8

## What the research says

- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## Why other serums fit oily skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, this ampoule is highly praised for repairing skin barriers and providing deep hydration for a glass skin effect without feeling heavy. It is a favorite for sensitive and dry skin types. A small number of users with fungal acne or sensitivity to ferments reported breakouts.

- Liked: Deep hydration (mostly mentioned)
- Liked: Strengthens skin barrier (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Estée Lauder dupe (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does the Bifida Biome Complex Ampoule work for oily skin?

This ampoule works moderately well for oily skin, as it helps strengthen the barrier and regulate oil production, though it does not directly manage oily shine. A treatment of this type needs ingredients like niacinamide, zinc PCA, and ferulic acid that control sebum, minimize pores, and address excess oil while keeping the skin comfortable and clear.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Which ingredients make this serum a good fit for oily skin?

Bifida Lysate Ferment and niacinamide make this serum a good fit for oily skin because they help strengthen the skin barrier and regulate oil production. To work best for oily skin, a product of this type needs ingredients that control excess oil and manage shine, such as niacinamide, zinc PCA, and ferulic acid.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### What does Bifida Ferment Lysate do for oily skin?

Bifida Ferment Lysate helps strengthen the outer skin layer and calm redness, making it a good fit for oily skin that gets easily irritated. It also provides antioxidant support and helps keep skin defenses balanced.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for oily skin?

This treatment goes in the evening routine, after cleansing and before moisturizing, for simplicity and extra safety around sun exposure. To better fit oily skin, this type of product needs ingredients that directly regulate oily shine and target excess oil.

### Can I use this serum with retinol, and in what order?

Yes, you can use this treatment with retinol by applying the serum first to help hydrate and calm your skin before putting on your retinol. It is unlikely to irritate your oily skin because it contains soothing components and lacks harsh ingredients. However, because it only offers moderate benefits for oily skin, oily skin also needs products with ingredients that directly control excess shine and balance oil production.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. It is safe for oily skin and unlikely to cause irritation, but an average fit for this skin needs ingredients that directly regulate oil and reduce shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is unlikely to cause irritation or breakouts on oily skin, as it contains no harsh ingredients and includes soothing components. However, this product type for oily skin needs ingredients that directly regulate oil and reduce shine.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/oily-skin) — Superior fit — AED 365.22 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — AED 715.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vita-c-serum/for/oily-skin) — High fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ae/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — AED 49.95 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ae/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — AED 49.99 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ae/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — AED 33.40 at Amazon

## Where to buy

- Amazon.ae: AED 99.12 (https://www.amazon.ae/dp/B08DTTL17D?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Butylene Glycol, Bifida Ferment Filtrate, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Saccharomyces Ferment Filtrate, Glycerin, Niacinamide, 1,2-Hexanediol, Lactobacillus Pumpkin Fruit Ferment Filtrate, Aureobasidium Pullulans Ferment, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Leontopodium Alpinum Callus Culture Extract, Cutibacterium Granulosum Extract Ferment Filtrate, Asiaticoside, Asiatic Acid, Madecassic Acid, Pentylene Glycol, Squalane, Hydrogenated Lecithin, Copper Tripeptide-1, Tromethamine, Acetyl Hexapeptide-8, Propanediol, Ethylhexylglycerin, Dextrin, Water, Caffeine, Benzyl Glycol, Sodium Phytate, Hydrolyzed Algin, Xanthan Gum, Epigallocatechin Gallate, Carbomer, Physalis Alkekengi Calyx Extract, Hydrolyzed Glycosaminoglycans, Polyglyceryl-10 Laurate, Theobroma Cacao Seed Extract, Adenosine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- France: https://lovi.care/skincare/fr/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/ma-nyo/bifida-biome-complex-ampoule/for/oily-skin (this page)