La Roche-Posay Anthelios Melt-In Milk Sunscreen SPF 60 for combination skin

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Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Chemical sunscreens containing avobenzone, octocrylene, homosalate, and octisalate showed no to minimal risks of dermal irritation, sensitization, photo-allergy, and photo-irritation in human subjects.

  Journal of Drugs in Dermatology, 2025

• Sunscreens containing Mexoryl SX provide superior protection against UVA- and solar-simulated radiation-induced biological damage, including pigmentation, DNA damage, immune suppression, and dermal alterations, compared to formulations without it in human volunteers and patients.

  Photodermatology, Photoimmunology & Photomedicine, 2008

• Mexoryl SX (5%) efficiently prevents UVA-induced skin alterations including pigmentation, stratum corneum thickening, and protein expression changes in human skin.

  Journal of Photochemistry and Photobiology. B, Biology, 1998

• Topical application of both a UVB absorber and a broad-spectrum Mexoryl SX sunscreen effectively prevented UVB-induced damage in in vitro reconstructed human skin, whereas only the Mexoryl SX-containing preparation successfully prevented UVA-specific dermal fibroblast disappearance.

  Photochemistry and Photobiology, 2000

• Encapsulation of ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane in lipid microparticles significantly reduced their in vivo human skin penetration compared to nonencapsulated filters.

  Skin Pharmacology and Physiology, 2011

• Microencapsulation of the BMDBM/HP-beta-CD complex in lipid microparticles significantly decreased the percutaneous penetration of the UV filter into the stratum corneum of human volunteers compared to the non-encapsulated sunscreen agent.

  Journal of Pharmaceutical and Biomedical Analysis, 2011

• Following human skin application of an O/W emulsion containing 2% BMDBM loaded in lipospheres, 15% of the sunscreen accumulated in the uppermost layers of the stratum corneum without remarkably modifying skin permeation compared to unencapsulated sunscreen.

  Skin Pharmacology and Physiology, 2008

• Dermal application of a sunscreen containing 10% homosalate in four volunteers resulted in delayed elimination with terminal half-times around 24 h and a bioavailability of cis-homosalate a factor of 2 lower than trans-homosalate, while metabolite ratios supported using oral-route urinary excretion fractions for dermal exposure assessments.

  Archives of Toxicology, 2024

• Homosalate exhibited the highest permeation among tested filters with a relative permeability rate of 4.2% and a depth of 60 um, and specific thickeners and emulsifiers successfully reduced its permeation without inhibiting the skin permeation of niacinamide.

  Photodermatology, Photoimmunology & Photomedicine, 2026

• An online-SPE-LC-MS/MS method successfully quantified specific urinary homosalate metabolites for up to 96 hours after dermal sunscreen application in a volunteer and detected metabolites exclusively in three German pilot participants who had used sunscreen within five days.

  Analytica Chimica Acta, 2021

• Simulated real-life dermal sunscreen exposure in twenty human volunteers leads to the systemic bioavailability and urinary excretion of the UV filter 2-ethylhexyl salicylate and its metabolite, reaching concentration peaks at 7 to 8 hours with 70-80% of overall excretion within 24 hours.

  Archives of Toxicology, 2019

• The application of a sunscreen formulation containing ethylhexyl methoxycinnamate, ethylhexyl salicylate, methyl anthranilate, and octocrylene does not significantly affect critical acne-related species such as Cutibacterium acnes and Staphylococcus epidermidis, refuting the induction of facial dysbiosis in men.

  Archives of Dermatological Research, 2024

• Controlled single dermal exposure to an EHS-containing sunscreen in three volunteers resulted in delayed systemic resorption with elimination half-lives between 6.6 and 9.7 hours, where the parent compound EHS occurred as the dominant urinary parameter.

  Archives of Toxicology, 2024

• Incorporating rosmarinic acid into sunscreens enhanced the in vivo SPF of octocrylene by over 157% and reduced lipid peroxidation in the human stratum corneum.

  Antioxidants, 2025

• Early application of sunscreen after ablative fractional skin resurfacing significantly increased the sensitization rate of the UV-filter, octocrylene, and the sunscreen compared to intact skin.

  The Journal of Dermatological Treatment, 2015

• Dermal sunscreen exposure in 20 healthy volunteers led to plasma concentrations of avobenzone, octocrylene, and its metabolite CDAA reaching up to 11 μg/L, 25 μg/L, and 1352 μg/L, respectively.

  Environment International, 2019

Ingredients

Avobenzone, Homosalate, Octisalate, Octocrylene, Water, Styrene Acrylates Copolymer, Dimethicone, Polymethylsilsesquioxane, Butyloctyl Salicylate, Glycerin, Alcohol Denat, Poly C10-30 Alkyl Acrylate, Caprylyl Methicone, Trisiloxane, Acrylates Dimethicone Copolymer, Diethylhexyl Syringylidenemalonate, Peg-100 Stearate, Glyceryl Stearate, Phenoxyethanol, Potassium Cetyl Phosphate, Propylene Glycol, Caprylyl Glycol, Peg-8 Laurate, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Triethanolamine, Tocopherol, Inulin Lauryl Carbamate, Disodium Edta, P-Anisic Acid, Caprylic Capric Triglyceride, Xanthan Gum, Cassia Alata Leaf Extract, Maltodextrin, Sodium Dodecylbenzenesulfonate

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.