# Isntree TW-Real Bifida Ampoule for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Isntree](https://lovi.care/skincare/ae/brands/isntree)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily skin; a few serums fit it even better.

## Why this fit

- High suitability for your oily skin is provided by niacinamide for oil regulation and willow bark extract for mild exfoliation, complementing the barrier-repairing benefits of Bifida Lysate Ferment and peptides like Palmitoyl Oligopeptide that also address fine lines.
- The inclusion of Allantoin and Beta-Glucan further supports skin barrier resilience and offers soothing effects, beneficial for maintaining overall skin health.
- The product demonstrates a strong safety profile with no irritation risks for oily skin, thanks to soothing ingredients and the absence of harsh components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Sodium Hyaluronate, Hydrolyzed Collagen, Copper Tripeptide-1

## What the research says

- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))

## What reviewers say

Based on a very large amount of data, users consistently praise this ampoule for its ability to strengthen the skin barrier and provide deep hydration without heaviness, resulting in a "glass skin" glow and smoother texture. It is highly effective for sensitive and dry skin types seeking anti-aging benefits. A small minority of users with acne-prone or very oily skin experienced minor breakouts or found the finish slightly tacky.

- Liked: Lightweight & fast absorbing (mostly mentioned)
- Liked: Hydrating & plumping (often mentioned)
- Liked: Strengthens skin barrier (often mentioned)
- Liked: Gentle & non-irritating (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Caused breakouts/irritation (rarely noted)
- Disliked: Texture/finish issues (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Isntree TW-Real Bifida Ampoule a great fit for oily skin?

Isntree TW-Real Bifida Ampoule is a great fit for oily skin because niacinamide helps balance oil while willow bark extract provides mild exfoliation. It is unlikely to cause irritation and supports a strong skin barrier with ingredients like Bifida Lysate Ferment, allantoin, and beta-glucan.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### Which ingredients make this serum a good fit for oily skin?

Niacinamide helps balance oil, while willow bark extract provides mild exfoliation without irritation. Together with soothing ingredients like allantoin and beta-glucan, these components help keep oily skin calm and healthy.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### What does Bifida Ferment Lysate do for oily skin?

Bifida Ferment Lysate helps strengthen the outer skin layer and calm redness, making it a good fit for oily skin that gets easily irritated. It also provides antioxidant support and helps keep skin defenses balanced.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for oily skin?

This treatment goes in the evening routine after cleansing and before moisturizing, keeping things simple and safe around sun exposure. It is a great fit for oily skin because niacinamide helps balance oil and willow bark extract provides mild exfoliation while soothing ingredients keep the skin calm.

### Can I use this serum with retinol, and in what order?

Yes, you can use this treatment with retinol by applying the treatment first and following with your retinol. This approach is unlikely to cause irritation for oily skin thanks to soothing ingredients like allantoin and beta-glucan.

### How often should I use this serum?

This treatment is intended for evening use, starting once a week and gradually increasing frequency if your skin tolerates it well. It is unlikely to cause irritation on oily skin due to its soothing ingredients.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is a great fit for oily skin and is unlikely to cause breakouts or clog pores, as it has a very safe formula with soothing ingredients and no harsh components. Niacinamide and willow bark extract help balance oil and gently clear pores while supporting your skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/oily-skin) — Superior fit — AED 365.22 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — AED 715.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vita-c-serum/for/oily-skin) — High fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ae/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — AED 49.95 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ae/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — AED 49.99 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ae/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — AED 33.40 at Amazon

## Where to buy

- Amazon.ae: AED 84.70 (https://www.amazon.ae/dp/B082TWZNYB?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Dipropylene Glycol, Niacinamide, Glycerin, Lactobacillus Pumpkin Extract Ferment, Lactobacillus Soybean Extract Ferment, Rice Ferment Filtrate Sake Ferment Filtrate, Sodium Hyaluronate, Hydrolyzed Collagen, Willow Bark Extract, Origanum Vulgare Leaf Extract, Cinnamomum Cassia Bark Extract, Portulaca Oleracea Extract, Chamaecyparis Obtusa Leaf Extract, Beta-Glucan, Palmitoyl Oligopeptide, Copper Tripeptide-1, Acetyl Hexapeptide-8, Allantoin, Hydroxyethylcellulose, Panthenol, Carbomer, Arginine, Butylene Glycol, Scutellaria Baicalensis Root Extract, Illicium Verum Fruit Extract Anise Fruit Extract, Adenosine, 1,2-Hexanediol, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- France: https://lovi.care/skincare/fr/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/isntree/tw-real-bifida-ampoule/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/isntree/tw-real-bifida-ampoule/for/oily-skin (this page)