Isntree C-Niacin Toning Ampoule for skin with dark spots

How to apply

Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo.

  Polymers, 2023

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• Topical application of a 5% Hippophae rhamnoides oil-in-water emulsion significantly improved skin hydration (p=0.0003) and transepidermal water loss (p=0.0087) compared to a placebo base formulation in 13 healthy male subjects over 84 days.

  Pakistan Journal of Pharmaceutical Sciences, 2014

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Topical application of a sea buckthorn fruit extract formulation significantly reduced skin sebum secretion in 10 healthy human volunteers compared to the control base over an 8-week period.

  Journal of Pharmacy & Bioallied Sciences, 2010

• Topical emulsions containing Hippophae rhamnoides and Cassia fistula plant extracts significantly reduced skin sebum contents compared to placebo in patients with grade I and grade II acne vulgaris.

  Postepy Dermatologii I Alergologii, 2014

• Sea buckthorn seed oil prevents UV-induced disturbances in redox balance and lipid metabolism in human keratinocytes and fibroblasts by reducing reactive oxygen species and lipid peroxidation products while enhancing antioxidant levels.

  Antioxidants, 2018

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.

  Clinical Pharmacology, 2018

• Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief.

  Plastic and Reconstructive Surgery, 2018

• Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo.

  Journal of Alternative and Complementary Medicine, 2010

Ingredients

Hippophae Rhamnoides Fruit Extract, Butylene Glycol, Pentylene Glycol, Glycerin, Betaine, Water, Niacinamide, Propanediol, Aloe Barbadensis Leaf Extract, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Pumpkin Fruit Extract, Physalis Alkekengi Fruit Extract, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Ocimum Sanctum Leaf Extract, Beta-Glucan, Curcuma Longa Root Extract, Corallina Officinalis Extract, Brassica Oleracea Italica Extract, Coccinia Indica Fruit Extract, Moringa Oleifera Seed Oil, Boswellia Serrata Extract Resin, Bioflavonoids, Panthenol, Allantoin, Sodium Polyacrylate, Tocopherol, Polysorbate 80, 1,2-Hexanediol, Ethyl Hexanediol, Ammonium Acryloyldimethyltaurate Vp Copolymer, 3-O-Ethyl Ascorbic Acid, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.