# iS Clinical Active Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [iS Clinical](https://lovi.care/skincare/ae/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers high suitability for your combination skin as Saccharum Officinarum Extract and Willow Bark Extract provide effective exfoliation to reduce blemishes and breakouts.
- Glycerin and Vaccinium Myrtillus Leaf Extract Fruit offer supportive hydration and mild cleansing benefits that complement your acne treatment.
- The formula is safe for your acne-prone skin, containing no harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/oily-acne-prone-skin): High

## Key ingredients

Saccharum Officinarum Extract, Vaccinium Myrtillus Extract, Arbutin, Willow Bark Extract, Polyporus Umbellatus Extract Mushroom Extract

## What the research says

- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Polyvinyl pyrrolidone-K90/Eudragit RL100 dissolving microneedle patches loaded with alpha-arbutin and resveratrol enhanced intradermal delivery by approximately 2.6 times compared to cream and slightly decreased the melanin index in human participants without causing skin irritation. ([Biomaterials Science, 2023](https://pubmed.ncbi.nlm.nih.gov/37183632/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))
- Water-soluble Vaccinium myrtillus extract reduced UVB-induced cytotoxicity, genotoxicity, and lipid peroxidation, and decreased UVA-induced genotoxicity, redox unbalance, and apoptosis in a human keratinocyte cell line (HaCaT). ([Journal of Photochemistry and Photobiology. B, Biology, 2014](https://pubmed.ncbi.nlm.nih.gov/24577051/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- A novel emulsion containing niacinamide, lens esculenta seed extract, and white willow bark extract effectively improved acne, blackheads, and conspicuous facial pores in 30 subjects with oily skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38140770/))
- White button mushroom extract treatment increased VEGF densities, EGF, PCNA, and collagen fibers, while decreasing apoptotic cells and limiting TGF-beta and CD4 reactions in ICR mice and chorioallantoic culture, indicating beneficial effects on skin regeneration and injury. ([Microscopy Research and Technique, 2012](https://pubmed.ncbi.nlm.nih.gov/22581761/))

## What reviewers say

Users consistently praise this serum as a "holy grail" multitasker that effectively targets adult acne while simultaneously smoothing fine lines and uneven texture. While the potent "tingling" sensation confirms its activity for most, the high price point and potential for dryness are common considerations for new users.

- Liked: Clears Acne & Breakouts (mostly mentioned)
- Liked: Improves Texture & Tone (often mentioned)
- Disliked: High Price Point (often mentioned)
- Liked: Anti-Aging Benefits (sometimes noted)
- Liked: Fast Visible Results (sometimes noted)
- Disliked: Intense Tingling Sensation (sometimes noted)
- Disliked: Drying for Some (rarely noted)
- Disliked: Risk of Counterfeits (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes iS Clinical Active Serum a great fit for acne-prone skin?

iS Clinical Active Serum is a great fit because Saccharum Officinarum Extract and Willow Bark Extract provide effective exfoliation to reduce blemishes and breakouts on your skin. Glycerin and Vaccinium Myrtillus Leaf Extract Fruit offer supportive hydration and mild cleansing benefits, while the formula is safe and avoids harsh ingredients that could cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

Saccharum Officinarum Extract and Willow Bark Extract make this serum a great fit by providing effective exfoliation that helps reduce blemishes and breakouts on acne-prone skin. Glycerin and Vaccinium Myrtillus Leaf Extract Fruit offer supportive hydration, while the formula's safe profile ensures it is unlikely to cause irritation.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/)

### What does Sugarcane Extract do for acne-prone skin?

Sugarcane extract provides glycolic acid, which helps smooth acne-prone skin and clears away dead cells that can clog pores. When used with acne treatments like adapalene, it is unlikely to cause irritation and may help reduce breakouts and skin complications.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30858720/)

### What does Bilberry Fruit Extract do for acne-prone skin?

Bilberry Fruit Extract helps improve skin smoothness and provides antioxidant protection, which supports an even complexion. For acne-prone skin, this type of product also needs soothing ingredients to keep the skin calm and clear.
Sources: [Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in your evening routine after cleansing and before moisturizing. Putting it in the evening keeps things simple and gives you extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum in your evening routine after cleansing and before your moisturizer, while keeping retinol for a different night to prevent irritation. Using active exfoliating ingredients and strong treatments together on acne-prone skin increases the likelihood of dryness or discomfort.

### How often should I use this serum?

This serum is a great fit for your acne-prone skin because its ingredients provide effective exfoliation to reduce blemishes while keeping your skin calm. Use it in the evening routine once a week to start, and if your skin tolerates it well and sees good results, you can carefully use it more often.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit for acne-prone skin because willow bark extract and sugar cane extract gently exfoliate to help clear blemishes and prevent breakouts. Glycerin and bilberry extract provide supportive hydration, and the formula is unlikely to cause irritation or clog pores.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for acne-prone skin

- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/acne-prone-skin) — Superior fit — AED 365.22 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — AED 715.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ae/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — AED 49.95 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ae/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — AED 49.99 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/ae/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — AED 91.81 at Amazon

## Where to buy

- Amazon.ae: AED 305.07 (https://www.amazon.ae/dp/B0073RK3S2?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Alcohol Denat, Saccharum Officinarum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Triethanolamine, Willow Bark Extract, Glyceryl Polyacrylate, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Menthol, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/active-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/active-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/active-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/active-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/active-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/active-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/active-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/active-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/acne-prone-skin (this page)