IOPE PDRN Caffeine Shot Serum for dry sensitive skin
Bio-Pdrn
Caffeine
Niacinamide
Adenosine
Lactobacillus Lysate FermentAverage
- HighDry Skin Fit
- AverageEffectiveness
- HighSafety
Works for dry sensitive skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your dry and flaky skin, as glycerin and beta-glucan provide essential hydration and barrier support. Niacinamide and caffeine also contribute to energizing and improving skin tone, aligning with general skincare needs.
- The formulation is highly suitable for dry skin due to the humectant action of glycerin and barrier repair from beta-glucan.
- The product is safe for your dry and sensitive skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
People Say
★4.8Overall rating based on 1.5k+ reviewsBased on a very large amount of data, users consistently praise this serum for its lightweight, fast-absorbing texture and its ability to visibly reduce facial puffiness and refine skin texture. While highly effective for "de-puffing" and strengthening the moisture barrier, some users with very dry skin find it requires an additional moisturizer, and the high price point is a frequent point of contention.
Highlights
Lightweight texture Mostly Mentioned
- “absorbs like water”
- “zero stickiness”
- “sinks right in”
- “lightweight and refreshing”
Reduces puffiness Often Mentioned
- “swelling goes down quickly”
- “jawline looks tighter”
- “less puffiness in morning”
- “face looks more contoured”
Expensive product Often Mentioned
- “price gives me pause”
- “wish it were affordable”
- “rationing it due to cost”
- “price-to-amount ratio is steep”
Gentle on skin Sometimes Noted
- “no irritation on sensitive days”
- “works gently”
- “didn't experience blemishes”
- “soothing feel”
Improves skin barrier Sometimes Noted
- “skin barrier feels stronger”
- “pores look managed”
- “skin became smoother”
- “refined skin texture”
Dry skin needs more Sometimes Noted
- “not heavy-duty hydration”
- “need cream afterwards”
- “felt tightness after a few hours”
- “too light for winter”
Minor breakouts Rarely Noted
- “small breakouts on forehead”
- “tiny red bumps”
- “caused minor texture issues”
Subtle anti-aging Rarely Noted
- “haven't noticed major firmness changes”
- “results are preventative”
- “didn't see dramatic transformation”
Sources: lovi.care, oliveyoung.co.kr, sokoglam.com, hwahae.co.kr, reddit.com, yesstyle.com, and more
Questions and answers
How well does IOPE PDRN Caffeine Shot work for dry sensitive skin?
IOPE PDRN Caffeine Shot Serum works moderately well for dry sensitive skin, providing essential hydration and barrier support through glycerin and beta-glucan while improving skin tone with niacinamide and caffeine. To fit this skin type even better, a treatment of this type needs rich moisturizing ingredients like ceramides and vitamin C to deliver maximum hydration, improve texture, and enhance resilience against environmental stressors.
Which ingredients make this serum a good fit for dry sensitive skin?
Glycerin and beta-glucan make this serum a good fit by providing essential hydration and barrier support for dry skin. A product of this type needs maximum beneficial ingredients that deeply hydrate and protect, along with ceramides and multiple forms of vitamin C to enhance skin resilience.
What does Bio-PDRN do for dry sensitive skin?
Bio-PDRN helps calm dry sensitive skin while supporting skin healing and barrier strength. It may improve skin texture and moisture without causing irritation, making it a gentle option for skin that is easily upset.
Journal of Cosmetic Dermatology, 2022Regenerative Medicine, 2020
What does Caffeine do for dry sensitive skin?
Caffeine helps wake up tired skin and reduces puffiness by boosting microcirculation, while also protecting delicate areas with antioxidants. Because sensitive skin can react easily, it is generally well tolerated when paired with soothing ingredients to keep the skin calm and comfortable.
Skin Pharmacology and Physiology, 2013Frontiers in Physiology, 2019
Where does this serum go in a skincare routine for dry sensitive skin?
This treatment goes in the evening routine after your soothing toner and before your moisturizer. Putting it in the evening helps keep your routine simple and adds extra safety around sun exposure. To get a better fit for dry and sensitive skin, this type of product needs rich soothing ingredients like ceramides, plant oils, and extra glycerin to deeply soften flaky skin.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to deliver gentle hydration and barrier support, followed by your retinol. This product is unlikely to irritate dry, sensitive skin due to the absence of harsh ingredients.
How often should I use this serum?
You can use this serum in your evening routine, applying it after your toner and before your moisturizer. To best care for dry sensitive skin, a product of this type needs rich hydration and barrier support from ingredients like glycerin and beta-glucan.
Can this serum clog pores, cause breakouts or purging for dry sensitive skin?
This serum is unlikely to cause breakouts or clog pores on dry sensitive skin, as it has a very low risk of irritation and reviewers rarely mention minor breakouts. However, dry skin often needs richer hydration and barrier support from heavier creams and oils to truly feel soft and smooth.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy.
Journal of Cosmetic Dermatology, 2021Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects.
International Journal of Molecular Sciences, 2025Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes.
Molecular Medicine Reports, 2023A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model.
Molecules, 2022A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks.
International Journal of Cosmetic Science, 2011Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects.
Frontiers in Physiology, 2019Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid.
AAPS PharmSciTech, 2021Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects.
Journal of Cosmetic Dermatology, 2022Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers.
International Journal of Medical Sciences, 2021Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials.
Current Issues in Molecular Biology, 2022
Ingredients
Lactobacillus Lysate Ferment, Water, Propanediol, Glycerin, Niacinamide, Butylene Glycol, Caffeine, Dipropylene Glycol, 2-Hexanediol, Diethoxyethyl Succinate, Glyceryl Polymethacrylate, Polyacrylate Crosspolymer-6, Mannitol, Ethylhexylglycerin, Adenosine, Sodium Citrate, Dextrin, Theobroma Cacao Extract, Citric Acid, Disodium Edta, T-Butyl Alcohol, Arginine, Cyclodextrin, Hydroxypropyl Cyclodextrin, Maltodextrin, Xanthan Gum, Beta-Glucan, Acetyl Tetrapeptide-11, Tocopherol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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