innisfree Tone Up No Sebum Sunscreen EX for acne-prone skin

Questions and answers

What the research says

• Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles selectively inhibited C. acnes, outperformed erythromycin in preclinical acne models, and safely reduced acne lesions and redness in a clinical trial.

  Journal of Controlled Release, 2025

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Lithospermum erythrorhizon and Pueraria lobata extracts scavenge free radicals, diminish ROS production, attenuate MMP-1 and MMP-3 expression, foster procollagen type I synthesis, and mitigate pro-inflammatory cytokine release in UVB-irradiated human skin keratinocytes.

  Photodermatology, Photoimmunology & Photomedicine, 2024

• Puerarin-loaded poly(l-lactic acid) electrospun patches provided sustained drug release, good biocompatibility, low cytotoxicity, and demonstrated anti-inflammatory and pro-collagen synthesis properties in H2O2-stimulated mouse fibroblasts and rat abdominal wall muscle defects.

  Advanced Science, 2024

• Nels cream achieved a similar reduction in inflammatory and noninflammatory lesion counts compared to 5% benzoyl peroxide in acne vulgaris patients, but caused significantly fewer side-effects such as peeling and dryness.

  Clinical and Experimental Dermatology, 2000

• Topically applied coated and uncoated zinc oxide nanoparticles under flexing and massage are retained in the stratum corneum with no significant penetration into the viable epidermis and no cellular toxicity in human skin.

  Nanomedicine, 2016

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport.

  Biomaterials Advances, 2022

• A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides.

  Medicina Cutanea Ibero-latino-americana, 1986

• Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models.

  Metabolites, 2021

• Tea seed oil makeup remover successfully removed foundation and eyeliner without causing skin irritation in 20 human volunteers, with the 60% formulation showing superior foundation removal compared to other formulations and an olive oil benchmark.

  Annales Pharmaceutiques Francaises, 2017

• Tea seed oil loaded nanostructured lipid carriers prepared with a combination of surfactants (NLC-C) showed significantly greater nontoxicity and hair growth-stimulating effects on human follicle dermal papilla cells compared to intact oil, while improving the sensory and diffusion properties of the hair serum.

  Pharmaceutics, 2022

• Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

  Journal of Cosmetic Dermatology, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

  Journal of Cosmetic Dermatology, 2024

Ingredients

Water, Zinc Oxide, Cyclohexasiloxane, Propanediol, Butyloctyl Salicylate, Butylene Glycol Dicaprylate Dicaprate, Disiloxane, Methyl Methacrylate Crosspolymer, Caprylyl Methicone, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Titanium Dioxide Ci 77891, Polypropylsilsesquioxane, Calcium Aluminum Borosilicate, Polymethylsilsesquioxane, Sodium Acrylates Crosspolymer-2, Disteardimonium Hectorite, Magnesium Sulfate, Triethoxycaprylylsilane, 1,2-Hexanediol, Polyglyceryl-2 Dipolyhydroxystearate, Dimethicone Vinyl Dimethicone Crosspolymer, Butylene Glycol, Parfum, Dicaprylyl Carbonate, Caprylyl Glycol, Glyceryl Caprylate, Mica, Iron Oxides Ci 77492, Ethylhexylglycerin, Iron Oxides Ci 77491, Sodium Hyaluronate, Pueraria Lobata Root Extract, Ulmus Davidiana Root Extract, Oenothera Biennis Flower Extract, Pinus Palustris Leaf Extract, Iron Oxides Ci 77499, Tocopherol, Jojoba Seed Oil, Camellia Sinensis Seed Oil, Glycerin, Epilobium Fleischeri Extract, Citric Acid, Potassium Sorbate

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.