# innisfree Retinol Cica Repair Ampoule for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/ae/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [innisfree](https://lovi.care/skincare/ae/brands/innisfree)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate treatment for blemishes and general skincare benefits, such as hydration and soothing, with supportive benefits for wrinkles and fine lines due to the presence of retinol and salicylic acid for desquamation regulation and niacinamide for barrier repair.
- Retinol and adenosine promote skin renewal and collagen production, addressing your main goal of wrinkles and fine lines.
- The product is safe for your normal skin due to the absence of prohibited or harsh ingredients and the presence of soothing ingredients like niacinamide and beta-glucan.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/innisfree/retinol-cica-repair-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/innisfree/retinol-cica-repair-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/innisfree/retinol-cica-repair-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ae/p/innisfree/retinol-cica-repair-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/innisfree/retinol-cica-repair-ampoule/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ae/p/innisfree/retinol-cica-repair-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/innisfree/retinol-cica-repair-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/innisfree/retinol-cica-repair-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol Vitamin A, Centella Asiatica, Niacinamide, Sodium Hyaluronate, Ceramide Np

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Based on a very large amount of data, this ampoule is highly recommended as a gentle introduction to retinol, particularly for sensitive skin. Users frequently report that it effectively hydrates and soothes, leading to smoother texture and fewer blemishes without causing irritation. However, individuals with advanced retinol experience may find the concentration too low for significant anti-aging effects, and some note that results can be subtle and require patience.

- Liked: Extremely gentle formula (mostly mentioned)
- Liked: Hydrating and moisturizing (often mentioned)
- Liked: Lightweight absorption (often mentioned)
- Liked: Improves texture/blemishes (sometimes noted)
- Disliked: Slow or subtle results (sometimes noted)
- Disliked: Not for advanced (rarely noted)
- Disliked: Pricey for amount (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Innisfree Retinol Cica Repair Ampoule work for mature skin?

Innisfree Retinol Cica Repair Ampoule works moderately well for mature skin by offering soothing hydration alongside retinol and salicylic acid to help smooth fine lines. While it brings helpful anti-aging care, a treatment for mature skin needs higher concentrations of potent antioxidants, skin-repairing peptides, and advanced anti-wrinkle ingredients to deliver optimal results safely without irritation.

### Which ingredients make this serum a good fit for mature skin?

Retinol, niacinamide, and adenosine make this serum a good fit for mature skin because they help smooth fine lines and support skin renewal. To work best for mature skin, a product of this type needs high concentrations of potent antioxidants, peptides, and hydrating ingredients that safely target wrinkles and improve skin elasticity without irritation.

### What does Retinol do for mature skin?

Retinol helps smooth out fine lines and wrinkles while making mature skin feel firmer and look more even in tone over time. It may occasionally cause dryness or stinging when you first start using it, so it works best when introduced slowly into your routine.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Centella Asiatica do for mature skin?

Centella asiatica helps mature skin by boosting moisture, keeping it smooth, and supporting collagen to make skin look firmer and less wrinkled. It also helps calm redness and protect skin from daily stress and aging.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516082/), [Scientific Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34188145/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Mature skin needs products with stronger collagen-boosting ingredients and richer hydrators for the best results against fine lines.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C by applying vitamin C in the morning and this retinol treatment at night to avoid overwhelming your skin. Mature skin needs a product with strong collagen boosters and rich hydrators to better smooth fine lines and keep the skin soft.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### How often should I use this serum?

Use this treatment in your evening routine once a week to start, and you may slowly use it more often if your skin tolerates it well without irritation. This helps smooth fine lines and renew mature skin safely while keeping it calm.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, but it may cause mild purging because it contains retinol. To better care for mature skin, a product needs strong collagen-boosting ingredients and rich barrier-repairing elements to effectively smooth fine lines.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — AED 347.75 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — AED 715.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ae/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — AED 65.43 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/ae/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — AED 493.00 at Amazon

## Where to buy

- Amazon.ae: AED 108.94 (https://www.amazon.ae/dp/B09Q8V2FQL?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 4 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Niacinamide, Dibutyl Adipate, Caprylic Capric Triglyceride, 1,2-Hexanediol, Hydrogenated Lecithin, Ammonium Acryloyldimethyl Taurate Vp Copolymer, Sunflower Seed Oil, Cholesterol, Allantoin, Soybean Oil, Tocopherol, Tocopheryl Acetate, Sodium Methyl Stearoyl Taurate, Propanediol, Carrot Extract, Ethylhexyl-Glycerin, Adenosine, Asiaticoside, Madecassic Acid, Camellia Sinensis Seed Extract, Asiatic Acid, Retinol, Stearyl Glycyrrhetinate, Sodium Hyaluronate, Mannitol, Ceramide Np, Beta-Glucan, Beta-Carotene, Phytosphingosine, Bht, Salicylic Acid, Acetyl Tetrapeptide-11
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- France: https://lovi.care/skincare/fr/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/innisfree/retinol-cica-repair-ampoule/for/mature-skin (this page)