🇦🇪United Arab Emirates

DRMTLGY Peptide Night Cream for oily acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

DRMTLGY Peptide Night Cream

Average

  • AverageOily Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for oily acne-prone skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate suitability for your oily skin due to humectants like glycerin and propanediol, but lacks strong seboregulation for your primary concerns of acne, blemishes, and breakouts.
  • The presence of ceramides and peptides enhances barrier resilience and provides excellent moisturizing benefits, supporting overall skin health.
  • The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of prohibited or harsh ingredients.

How to apply

  • Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
  • Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
  • Gently press a small amount into your skin and avoid rubbing to keep pores clear.
  • Apply on clean, slightly damp skin to help the product absorb better and control oil.
  • Avoid the sensitive eye area and do a simple patch test before your first use.

People Say

★4.9Overall rating based on 2.4k+ reviews

Based on a very large amount of data, this fragrance-free night cream is highly regarded for its rich yet non-greasy texture, providing deep hydration and plumping effects. Users frequently report improvements in skin texture, reduced fine lines, and a strengthened moisture barrier, making it suitable for sensitive and aging skin types. Some users find the jar packaging unhygienic, and a few with very dry skin may require additional moisture, while others note it can be too heavy for daytime use. Availability can also be a concern due to frequent sell-outs.

Highlights

  • Deep hydration Mostly Mentioned
    • “quenches skin's thirst”
    • “woke up glowing”
    • “no more dry patches”
  • Gentle formula Often Mentioned
    • “no irritation”
    • “fragrance-free”
  • Non-greasy texture Often Mentioned
    • “soaks right in”
    • “fluffy texture”
    • “lightweight but rich”
  • Anti-aging benefits Sometimes Noted
    • “softens fine lines”
    • “skin looks younger”
    • “improves skin elasticity”
  • Value for money Sometimes Noted
    • “better than high-end”
    • “great price point”
    • “affordable luxury”
  • Jar packaging Sometimes Noted
    • “wish it had a pump”
    • “don't like dipping fingers”
    • “prefer airless dispenser”
  • Availability issues Rarely Noted
    • “shipping takes time”
    • “only available online”
    • “sold out frequently”
  • Not rich enough Rarely Noted
    • “need to layer oil”
    • “not enough for winter”
    • “dried out by morning”
  • Too heavy for day Rarely Noted
    • “too thick for day”
    • “shiny under makeup”
    • “strictly a night cream”

Sources: lovi.care, drmtlgy.com, amazon.com, reddit.com, youtube.com, makeupalley.com, and more

Questions and answers

How well does DRMTLGY Peptide Night Cream work for oily acne-prone skin?

This cream works moderately well for oily skin since it provides good moisture, but it lacks oil-controlling ingredients to manage breakouts. An ideal product for this skin type needs lightweight hydration, barrier-supporting ingredients like ceramides, and blemish-clearing components that do not add excess oil.

International Journal of Cosmetic Science, 2024Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this cream a good fit for oily acne-prone skin?

Glycerin and propanediol make this cream a good fit for oily skin by providing moderate hydration and supporting the moisture barrier. However, because this product is an average fit, a product of this type for oily acne-prone skin needs powerful hydrating and repairing ingredients that clear blemishes without adding excess oil, along with ingredients that control oil and do not clog pores.

International Journal of Cosmetic Science, 2024Clinical, Cosmetic and Investigational Dermatology, 2017

What do Peptides do for oily acne-prone skin?

Peptides help calm oily, acne-prone skin by targeting acne-causing bacteria and reducing redness and swelling. Advanced delivery methods like nanomicelles may also improve how deeply these helpful ingredients sink into the skin.

Advanced Science, 2025Bioorganic Chemistry, 2025

What do Ceramides do for oily acne-prone skin?

Ceramides help restore the protective barrier of oily, acne-prone skin, which often lacks these vital lipids and suffers from moisture loss and irritation. Using products with ceramides supports skin hydration, calms redness, and improves overall texture while managing breakouts.

Journal of Cosmetic Dermatology, 2026Journal of Cosmetic Dermatology, 2023

Where does this cream go in a skincare routine for oily acne-prone skin?

This moisturizing treatment goes at the end of your evening routine, right after your treatment step. Oily acne-prone skin needs a product of this type that also balances oil and targets blemishes.

Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol in your evening routine by applying your retinol first and following it with the moisturizer. This cream helps keep your skin soft and comfortable while you use retinol, though oily acne-prone skin needs a moisturizer that also targets excess oil and breakouts.

Cutis, 2006

How often should I use this cream?

You can use this cream daily, applying it as part of your regular moisturizing routine. It helps keep your skin soft and comfortable while supporting your skin barrier, though oily skin of this type needs added oil-controlling ingredients and blemish-fighting actives to manage breakouts effectively.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this cream clog pores, cause breakouts or purging for oily acne-prone skin?

This cream is unlikely to cause irritation or breakouts on your oily skin due to its gentle ingredients, but it may feel a bit heavy and lacks strong oil-control ingredients. For an ideal fit with oily acne-prone skin, a moisturizer needs ingredients that balance oil production and clear blemishes.

Can I use this cream around the eyes or on my body?

You can use this cream around your eyes and on your body, as its gentle formula is well tolerated by different skin areas. While the thin skin around the eyes and various body regions benefit from rich moisturizers, oily skin generally needs a lighter texture and oil-controlling ingredients for targeted care in those areas.

Surgical and Radiologic Anatomy, 2002International Journal of Cosmetic Science, 2024

Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

What the research says

  • Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits.

    International Journal of Cosmetic Science, 2024

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days.

    Molecules, 2021

  • A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

    Lasers in Medical Science, 2025

  • A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

    International Journal of Cosmetic Science, 2025

  • Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

    Journal of Cosmetic Dermatology, 2025

  • Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

    Contemporary Clinical Trials Communications, 2021

  • Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

    Journal of Cosmetic Dermatology, 2024

  • Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.

    Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016

  • A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.

    Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

  • An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.

    Aesthetic Plastic Surgery, 2018

Why other moisturizers fit oily acne-prone skin better

Ingredients

Water, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii Butter Shea Butter, Caprylic Capric Triglyceride, Cetyl Alcohol, Dimethicone, Peg-100 Stearate, Ceramide Eop, Ceramide Ap, Palmitoyl Tetrapeptide-7, Ceramide Np, Palmitoyl Tripeptide-1, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Allantoin, Phytosphingosine, Cholesterol, Tridecane, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Butylene Glycol, Glycol Distearate, Ethylhexylglycerin, Potassium Cetyl Phosphate, Carbomer, Sodium Hydroxide, Disodium Edta, Sodium Lauroyl Lactylate, Polysorbate 20, Dextran, Xanthan Gum, Phenoxyethanol, Magnesium Chloride

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

Scan your face, then any product.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play

How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play