# Biossance Squalane + Vitamin C Dark Spot Serum for skin with dark spots

**Lovi Fit: Superior fit for skin with dark spots.**
Normal Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Biossance](https://lovi.care/skincare/ae/brands/biossance)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for skin with dark spots.

## Why this fit

- Excellent for your normal skin, this serum's 3-O-Ethyl Ascorbic Acid and Glycyrrhiza Glabra Root Extract effectively target pigmentation concerns by brightening and evening skin tone.
- The inclusion of Squalane and Glycerin further supports your skin by providing antioxidant activity and essential hydration, enhancing overall skin health.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots): Superior (this page)
- [Mature skin](https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/oily-acne-prone-skin): Superior

## Key ingredients

Ascorbic Acid, Squalane, White Shiitake Mushroom Extract, Licorice Root Extract, Sodium Hyaluronate

## What the research says

- A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Concurrent treatment with 3-O-ethyl ascorbic acid and cannabigerol in UVB-irradiated human keratinocytes prevents membrane structure alterations, promotes cell survival, enhances antioxidant enzyme activity and GSH- and Trx-dependent systems, reduces lipid and protein oxidative modifications, and exerts anti-inflammatory effects. ([Free Radical Biology & Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/39778604/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Lentinan reduced benzo(a)pyrene-induced oxidative stress, malondialdehyde levels, and inflammatory cytokine production while increasing antioxidant enzyme activities in human keratinocytes. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31135098/))
- Shiitake mushroom ethanol extract exhibited moderate antioxidant capacity, 51.99% elastase inhibition, concentration-dependent collagenase suppression, and non-toxicity in human keratinocytes, supporting its safe incorporation into stable topical anti-aging skin-care formulations. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41656649/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Based on a very large amount of data, this serum is frequently praised for its lightweight, milky texture that hydrates while effectively brightening dull complexions and fading acne scars over time. Many with sensitive skin find it gentle and non-irritating, although a subset of users experienced no visible changes in pigmentation or suffered severe allergic reactions like redness and swelling.

- Liked: Brightens complexion (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Hydrating texture (often mentioned)
- Liked: Gentle formula (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Allergic reactions (rarely noted)
- Disliked: Poor packaging (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Biossance Squalane + Vitamin C Dark Spot Serum one of the best fits for skin with dark spots?

This serum is a great fit because its 3-O-Ethyl Ascorbic Acid and licorice root extract brighten and even out skin tone. It also keeps skin healthy and hydrated with squalane and glycerin while avoiding harsh ingredients to keep your skin calm and safe from irritation.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which ingredients make this serum a good fit for skin with dark spots?

This serum is a great fit for dark spots because its 3-O-Ethyl Ascorbic Acid and Licorice Root Extract effectively brighten and even out skin tone. Squalane and glycerin also help by giving your skin essential hydration and antioxidant support without causing irritation.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What does Vitamin C do for skin with dark spots?

Vitamin C helps fade dark spots and brightens uneven skin. It works by slowing down pigment production and boosting overall skin clarity.
Sources: [Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029672/)

### What does Squalane do for skin with dark spots?

Squalane helps keep skin soft and smooth, but it is unlikely to directly fade dark spots on its own. For hyperpigmentation, this type of product needs added brightening ingredients like vitamin C or antioxidants to help even out skin tone.

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment serum goes in the evening routine after your cleansing toner and before your moisturizer. Putting it at night helps keep things simple and avoids extra sun exposure while targeting your dark spots.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this vitamin C treatment in the morning and saving your retinol for your evening routine. This helps you target dark spots effectively while keeping your skin calm, as the soothing ingredients and gentle formula are unlikely to cause irritation.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### How often should I use this serum?

Use this serum in your evening routine. It effectively targets dark spots and brightens your skin tone while keeping your skin calm and hydrated.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to clog pores or cause breakouts on skin with dark spots because it is free of heavy, pore-blocking ingredients and includes soothing components. It also does not typically cause purging since it focuses on brightening dark spots rather than speeding up skin cell turnover.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — AED 347.75 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/dark-spots) — High fit — AED 365.22 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/ae/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — AED 499.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ae/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — AED 49.95 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/ae/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — AED 64.25 at Amazon
- Moisturizer: [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/ae/p/isntree/green-tea-fresh-serum/for/dark-spots) — Superior fit — AED 75.41 at Amazon

## Where to buy

- Amazon.ae: AED 270.10 (https://www.amazon.ae/dp/B08R6F1BS5?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Glycerin, 3-O-Ethyl Ascorbic Acid, Squalane, Lentinus Edodes Mycelium Extract, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Sodium Hyaluronate, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Xanthan Gum, Sodium Gluconate, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots (this page)