# AXIS-Y Artichoke Intensive Skin Barrier Ampoule for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [AXIS-Y](https://lovi.care/skincare/ae/brands/axis-y)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ae/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for combination skin, as sodium hyaluronate and beta-glucan provide excellent moisturizing and barrier support, which can help with oily shine. Aloe barbadensis leaf water and centella asiatica extract further hydrate and soothe, offering general skincare benefits.
- While the formula provides good hydration and barrier enhancement, it lacks sufficient ingredients for strong oil control, which is a primary concern for your oily shine.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Cynara Scolymus Extract, Sodium Hyaluronate, Centella Asiatica Extract, Glycerin, Glycyrrhiza Glabra Root Extract Licorice Root Extract

## What the research says

- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- An artichoke extract cosmetic formulation enhanced skin roughness by 19.74% and elasticity by 11.45% in human subjects compared to a placebo cream, alongside exhibiting antioxidant, anti-inflammatory, and anti-aging cellular effects. ([Molecules, 2018](https://pubmed.ncbi.nlm.nih.gov/30360471/))
- Luteolin inhibited the mRNA expression of antimicrobial peptides and increased cornified envelope proteins in TNF-alpha/IL-17A/IFN-gamma-stimulated HaCaT cells by regulating the TRAF6/IkappaB/NF-kappaB signaling pathway. ([Food Science and Biotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40655288/))
- Antioxidants and luteolin topically applied decrease UV-B induced apoptosis and downregulate pro-inflammatory cytokines in kindler syndrome keratinocyte cultures. ([Human Molecular Genetics, 2016](https://pubmed.ncbi.nlm.nih.gov/27798104/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))

## Why other moisturizers fit combination skin better

- A peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved adult female acne by decreasing lesion counts, sebum production, GAGS scores, and local androgen levels while increasing beclin-1 levels. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28342238/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

This ampoule is widely praised as a lightweight, fast-absorbing treatment that excels at soothing irritated skin and repairing a damaged moisture barrier, particularly for oily, acne-prone, and sensitive skin types. Users frequently note that while it provides excellent hydration and redness relief without stickiness, those with very dry skin often need to layer it with a heavier moisturizer.

- Liked: Soothing & calming (mostly mentioned)
- Liked: Hydrating (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Barrier repair (sometimes noted)
- Disliked: Not moisturizing enough (sometimes noted)
- Disliked: Small size/price (sometimes noted)
- Disliked: Alcohol content (rarely noted)
- Disliked: Breakouts/reaction (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does AXIS-Y Artichoke Ampoule work for combination skin?

This ampoule offers moderate suitability for combination skin because sodium hyaluronate and beta-glucan provide good moisture and barrier support that can help with oily shine. However, it lacks sufficient ingredients for strong oil control, which combination skin needs to stay balanced.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for combination skin?

Sodium hyaluronate and beta-glucan help moisturize and support your skin barrier, while aloe water and centella extract help hydrate and calm. To work best for combination skin, a treatment of this type also needs targeted oil-control ingredients to properly manage oily shine.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Artichoke Extract do for combination skin?

Artichoke Extract helps keep combination skin looking smooth and balanced by tightening the look of pores and managing oily areas without making dry patches feel tight. It works well in daily routines to help keep your face feeling fresh and clear.

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps the routine simple and safe around sun exposure. Combination skin also needs targeted oil-control ingredients to properly manage oily shine.

### Can I use this serum with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying it before your retinol to help calm and hydrate your skin. Using a barrier-enhancing moisturizer along with retinoids is unlikely to cause irritation and may make your skin more comfortable during the treatment. Combination skin of this type needs additional oil-balancing ingredients like niacinamide or salicylic acid to properly manage shine.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

This treatment is used in the evening in the routine for combination skin. Some treatments may also be used in the morning or twice a day depending on preference and tolerance.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause breakouts or irritation for combination skin, as it is safe and free of harsh ingredients. However, it may not provide enough oil control for your oily areas, so combination skin often needs lightweight hydrators paired with stronger oil-balancing ingredients.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Can I use this serum around the eyes or on my body?

You can safely apply this moisturizing treatment to the thin skin around the eyes and on the body since it has a gentle profile without harsh ingredients. This type of product needs extra soothing extracts and deep hydration to properly care for delicate eye areas and dry body skin.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for combination skin

- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/ae/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/combination-skin) — High fit — AED 92.81 at Amazon
- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/ae/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/combination-skin) — High fit — AED 53.01 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/ae/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/combination-skin) — High fit — AED 45.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ae/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — AED 145.00 at Amazon
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/ae/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — AED 179.45 at Amazon

## Where to buy

- Amazon.ae: AED 33.81 (https://www.amazon.ae/dp/B08CBP84MR?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Aloe Barbadensis Leaf Water, Butylene Glycol, Sodium Hyaluronate, Centella Asiatica Extract, Glycerin, Betaine, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Alcohol, Cynara Scolymus Extract, Sorbitol, Sorbitan Sesquioleate, Hieracium Pilosella Extract, Rheum Palmatum Root Extract, Althaea Rosea Flower Extract, Aloe Barbadensis Leaf Extract, Dimethyl Sulfone, Chlorphenesin, Xanthan Gum, Peg-60 Hydrogenated Castor Oil, Ethylhexylglycerin, Polyglutamic Acid, Beta-Glucan, Arginine, Linum Usitatissimum Seed Extract, Hibiscus Esculentus Fruit Extract, Aloe Barbadensis Leaf Juice, Arctium Lappa Root Extract, Hibiscus Mutabilis Flower Extract, Corchorus Olitorius Leaf Extract, Allantoin, Carbomer, Adenosine, Melaleuca Alternifolia Tree Oil Leaf
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- France: https://lovi.care/skincare/fr/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin (this page)