# Anua NANO RETINOL™ 0.3% + NIACIN RENEWING SERUM for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Anua](https://lovi.care/skincare/ae/brands/anua)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Offers high suitability for normal skin as niacinamide and hyaluronic acid provide humectant action and barrier repair, complementing your goal of addressing wrinkles and fine lines.
- Retinol and adenosine in moderate concentrations further promote skin renewal, smoothing texture and minimizing fine lines for effective results.
- The product is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin): High

## Key ingredients

Retinol, Niacinamide, Hyaluronic Acid, Panthenol, Allantoin

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))

## What reviewers say

Users find this serum to be an excellent gentle introduction to retinol, effectively smoothing skin texture and refining pores with minimal irritation. While improvements to fine lines and blackheads require consistent use, the formula hydrates and plumps the skin, leaving it glowing and moisturized.

- Liked: Gentle & non-irritating (often mentioned)
- Liked: Improves texture & pores (often mentioned)
- Liked: Brightening effect (sometimes noted)
- Liked: Elegant texture (sometimes noted)
- Liked: Hydrating & plumping (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Initial sensitivity (rarely noted)
- Disliked: Scent preferences (rarely noted)
- Disliked: Small quantity (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Anua Nano Retinol 0.3% + Niacin Renewing Serum a great fit for mature skin?

This serum is a great fit for mature skin because retinol and adenosine help smooth texture and minimize fine lines by renewing the skin. Niacinamide and hyaluronic acid also help by keeping the skin plump and repairing its barrier, while panthenol and allantoin keep it calm.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because retinol and adenosine help smooth texture and minimize fine lines, while niacinamide and hyaluronic acid support skin renewal and barrier repair. These ingredients work together to effectively address signs of aging while keeping the skin soft and calm.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Retinol do for mature skin?

Retinol helps smooth out fine lines and wrinkles while improving overall skin thickness and firmness over time. It may also cause temporary dryness, scaling, or stinging as your skin gets used to it.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for mature skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Using it at night helps the retinol and niacinamide smooth texture and soften fine lines without extra irritation.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C, but it is best to apply vitamin C in the morning and save this treatment for your evening routine to keep your skin calm. Using them at different times of day helps your skin handle both active ingredients safely and effectively without feeling overwhelmed.

### How often should I use this serum?

Use this serum in your evening routine, starting about once a week and gradually increasing as your skin adjusts. This ingredient and strength help smooth texture and soften fine lines with a low risk of irritation.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or clog pores on mature skin, and initial sensitivity is low because it is free of harsh ingredients. It helps smooth texture and soften fine lines safely over time, though mild initial purging may occasionally happen when starting retinol.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — AED 347.75 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — AED 715.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ae/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — AED 65.43 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/ae/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — AED 493.00 at Amazon

## Where to buy

- Amazon.ae: AED 64.65 (https://www.amazon.ae/dp/B0CRSZDX59?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Niacinamide, Glycerin, Butylene Glycol, 1,2-Hexanediol, Panthenol, Hyaluronic Acid, Allantoin, Betaine, Tocopherol, Ethylhexylglycerin, Adenosine, Caprylyl Glycol, Xanthan Gum, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin (this page)