AMOREPACIFIC Time Response Skin Reserve Serum for acne-prone skin

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Questions and answers

What the research says

• Topical and in vitro application of a Camellia sinensis leaf extract demonstrated immunomodulatory, detoxification, anti-inflammatory, and antioxidant properties while improving mood states, skin hydration, barrier function, rejuvenation, and facial skin health.

  International Journal of Cosmetic Science, 2025

• Panax ginseng root extract induced Type I procollagen synthesis and COL1A2 promoter activity through Smad2 phosphorylation in human dermal fibroblast cells.

  Journal of Ethnopharmacology, 2007

• A mixture of Panax ginseng and Crataegus pinnatifida prevented skin aging by improving procollagen type I expression, diminishing matrix metalloproteinase-1 secretion, reducing skin roughness and photodamage scores, and decreasing loss of skin moisture in human dermal fibroblasts and healthy human skin.

  Journal of Ginseng Research, 2017

• Epigallocatechin-3-gallate significantly improved acne in patients compared to the control side during an 8-week clinical trial.

  The Journal of Investigative Dermatology, 2013

• An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.

  Clinical, Cosmetic and Investigational Dermatology, 2019

• Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction.

  Journal of Clinical and Diagnostic Research, 2017

• Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo.

  Experimental Dermatology, 2009

• Topical application of green tea extract encapsulated chitosan microparticles improved skin elasticity, melanin index, and facial wrinkles compared to a placebo in female volunteers without causing skin irritation.

  Journal of Cosmetic Dermatology, 2022

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects.

  Rejuvenation Research, 2015

• A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects.

  Journal of Ginseng Research, 2022

• A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline.

  Journal of Toxicology and Environmental Health. Part A, 2020

• Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism.

  Evidence-based Complementary and Alternative Medicine, 2015

• Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo.

  Experimental Dermatology, 2015

• Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.

  Advanced Science, 2025

Why other serums fit acne-prone skin better

• Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris.

  The Journal of Clinical and Aesthetic Dermatology, 2020

• A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.

  Clinical Pharmacology, 2018

• Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.

  BioMed Research International, 2022

Ingredients

Camellia Sinensis Leaf Water, Butylene Glycol, Water, Glycerin, Alcohol, Trehalose, Phyllostachis Bambusoides Juice, Glycereth-26, Hydrogenated Poly C6-14 Olefin, Dimethicone, Hydrogenated Lecithin, Propanediol, Pentaerythrityl Tetraethylhexanoate, Polymethylsilsesquioxane, Panthenol, Cetearyl Olivate, 1,2-Hexanediol, Peg-5 Rapeseed Sterol, Sorbitan Olivate, Sodium Polyacrylate, Hydrogenated Polydecene, Parfum, Ammonium Acryloyldimethyltaurate Vp Copolymer, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Tromethamine, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Adenosine, Disodium Edta, Ethylhexylglycerin, Beta-Glucan, Ppg-5-Laureth-5, Glycine Soja Seed Extract Soybean Seed Extract, Natto Gum, Dextrin, Theobroma Cacao Extract, Camellia Sinensis Leaf Extract, Phenoxyethanol, Poloxamer 235, Betaine, Ethoxydiglycol, Epigallocatechin Gallate, Camellia Sinensis Flower Extract, Tocophersolan, Poloxamer 338, Panax Ginseng Root Extract, Glucose, Acetic Acid, Potassium Hydroxide, Caprylyl Glycol, Tocopherol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.