# Aestura A-Cica 365 Blemish Calming Serum for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Aestura](https://lovi.care/skincare/ae/brands/aestura)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your normal skin and redness concerns as Madecassoside and Beta-Glucan offer significant calming and barrier repair. Niacinamide further supports your skin by providing anti-inflammatory action and improving overall skin health.
- The inclusion of Squalane and Tocopherol offers additional nourishment and antioxidant protection, beneficial for maintaining your skin's hydration and resilience.
- The product is safe for your sensitive skin, featuring soothing ingredients and avoiding harsh or prohibited components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica, Niacinamide, Madecassoside, Beta-Glucan, Squalene

## What the research says

- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Squalene exhibits advantages for the skin as an emollient, antioxidant, hydrating agent, and antitumor substance based on in vitro and in vivo models. ([Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Topical application of oat beta-glucan ameliorates epidermal hyperplasia and accelerates epidermal barrier recovery by promoting keratinocyte differentiation through dectin-1-mediated ERK and p38 signaling pathways that upregulate CaSR expression. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34237364/))
- A single use of an alpha-tocopherol-enriched rinse-off product strongly increases alpha-tocopherol levels in skin barrier lipids maintained for at least 24 hours and significantly inhibits squalene photooxidation in human volunteers compared to a control product. ([Skin Pharmacology and Physiology, 2005](https://pubmed.ncbi.nlm.nih.gov/15608499/))
- The investigated actives incorporated into alkyl polyglucoside emulsifier-stabilized creams showed no skin irritation and provided increased skin hydration and reduced transepidermal water loss in 76 healthy volunteers. ([Vojnosanitetski Pregled, 2016](https://pubmed.ncbi.nlm.nih.gov/29328637/))
- Topical treatment with a mixed RetinSphere - vitamin E formulation significantly decreased lipid peroxidation levels and oxidized squalene percentage, reduced interleukin-1α concentration in lesional areas, and led to clinical improvement in 18 patients with mild comedonal acne. ([Journal of the European Academy of Dermatology and Venereology, 2014](https://pubmed.ncbi.nlm.nih.gov/24628899/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised by users with sensitive and acne-prone skin for its ability to rapidly soothe redness and repair the skin barrier without causing irritation. The lightweight, non-sticky formula is effective for calming inflammation and improving texture. However, many users find the small bottle size and high price point to be significant drawbacks.

- Disliked: Expensive for size (mostly mentioned)
- Liked: Calms redness fast (often mentioned)
- Liked: Gentle, non-irritating (often mentioned)
- Liked: Lightweight, non-sticky (often mentioned)
- Liked: Hydrating for oily (sometimes noted)
- Liked: Improves texture (sometimes noted)
- Disliked: Not enough for dry (sometimes noted)
- Disliked: Heavy for summer (rarely noted)
- Disliked: Slightly tacky (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Aestura A-Cica 365 Blemish Calming Serum a great fit for sensitive skin?

This serum is a great fit for sensitive skin because ingredients like Madecassoside and Beta-Glucan calm the skin and repair its barrier, while Niacinamide helps reduce redness and improve overall skin health. It is safe for sensitive skin as it avoids harsh components and includes soothing ingredients that help keep your skin hydrated and resilient.
Sources: [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Which ingredients make this serum a good fit for sensitive skin?

Madecassoside, Beta-Glucan, and Centella Asiatica make this serum a great fit because they offer significant calming and barrier repair for sensitive skin. Niacinamide further supports your skin by providing anti-inflammatory action and improving overall skin health.
Sources: [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### What does Centella Asiatica do for sensitive skin?

Centella asiatica helps calm sensitive skin and keeps it feeling soft by soothing irritation and supporting the skin barrier. It is unlikely to cause trouble and may help reduce redness and discomfort over a few weeks of regular use.
Sources: [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682399/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine after your toner and before your moisturizer. Putting it in the evening helps keep your routine simple and adds safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol, applying the serum first to help calm your skin and provide moisture before putting on your retinol. Using soothing ingredients like beta-glucan alongside active treatments helps keep your skin comfortable and supports your skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### How often should I use this serum?

This serum fits into your evening routine as a treatment step, applied after your soothing toner and before your moisturizer. Using it at night keeps things simple and provides extra safety around sun exposure, though some treatments can also be used in the morning or twice a day.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin because it is formulated with soothing ingredients and avoids harsh components.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — AED 347.75 at Amazon
- [Clarins Double Serum](https://lovi.care/skincare/ae/p/clarins/double-serum/for/sensitive-skin) — High fit — AED 440.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — AED 715.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — AED 84.53 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ae/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — AED 81.41 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/ae/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — AED 65.10 at Amazon

## Where to buy

No store in United Arab Emirates has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Butylene Glycol, Dipropylene Glycol, Betaine, Niacinamide, 1,2-Hexanediol, Alcohol Denat, Squalene, Diethoxyethyl Succinate, Polyglyceryl-10 Stearate, Sucrose Stearate, Polymethyl Methacrylate, Polyglyceryl-10 Laurate, Phytosterols, Caprylyl Methicone, Carbomer, Hydrogenated Lecithin, Hydrogenated Phosphatidylcholine, Tromethamine, Ethylhexylglycerin, Xanthan Gum, Propanediol, Cellulose Gum, Disodium Edta, Madecassoside, Beta-Glucan, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin (this page)