# Protease and palmitoyl tripeptide-1 Page: https://lovi.care/skincare/ae/ingredients/protease-and-palmitoyl-tripeptide-1 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates. Keep them apart Use them at different times of day, applying the [protease](https://lovi.care/skincare/ae/ingredients/protease) first and the peptide later, because they cancel each other out. The protease enzyme breaks down the peptide before it can smooth your skin. You can separate them by using one in the morning and the other at night. - [All about protease](https://lovi.care/skincare/ae/ingredients/protease) - [All about palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/palmitoyl-tripeptide-1) ### [Protease](https://lovi.care/skincare/ae/ingredients/protease) products - [COSRX Centella Cleansing Powder](https://lovi.care/skincare/ae/p/cosrx/centella-cleansing-powder/for/combination-skin) — Superior fit - [FANCL Deep Clear Washing Powder](https://lovi.care/skincare/ae/p/fancl/deep-clear-washing-powder/for/oily-skin) — High fit — [AED 120.75 at Amazon](https://www.amazon.ae/dp/B091PJNLCB?tag=lovi00-21&linkCode=osi&th=1&psc=1) ### [Palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/palmitoyl-tripeptide-1) products - [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/ae/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [AED 150.00 at Amazon](https://www.amazon.ae/dp/B0C9DXGXZ3?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/ae/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit - [Medik8 Liquid Peptides](https://lovi.care/skincare/ae/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [AED 469.66 at Amazon](https://www.amazon.ae/dp/B0DYV9VSDV?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [Shiseido Benefiance Wrinkle Smoothing Eye Cream](https://lovi.care/skincare/ae/p/shiseido/benefiance-wrinkle-smoothing-eye-cream/for/mature-skin) — High fit — [AED 295.86 at Amazon](https://www.amazon.ae/dp/B0C9RXV1VY?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/ae/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [AED 297.75 at Amazon](https://www.amazon.ae/dp/B09FG8TJDD?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [Alastin Skincare Regenerating Skin Nectar](https://lovi.care/skincare/ae/p/alastin-skincare/regenerating-skin-nectar/for/mature-skin) — Superior fit - [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ae/p/the-ordinary/matrixyl-10-ha/for/dry-skin) — Superior fit - [ZO Skin Health Daily Power Defense](https://lovi.care/skincare/ae/p/zo-skin-health/daily-power-defense/for/oily-skin) — High fit — [AED 831.00 at Amazon](https://www.amazon.ae/dp/B08K8T4HPJ?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/ae/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit - [Alastin Ultra Nourishing Moisturizer](https://lovi.care/skincare/ae/p/alastin/ultra-nourishing-moisturizer/for/dry-skin) — Superior fit - [DRMTLGY Needle-less Serum](https://lovi.care/skincare/ae/p/drmtlgy/needle-less-serum/for/dry-skin) — Superior fit — [AED 224.20 at Amazon](https://www.amazon.ae/dp/B0CJK22LNX?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [Valmont Prime Renewing Pack](https://lovi.care/skincare/ae/p/valmont/prime-renewing-pack/for/mature-skin) — High fit ## Questions and answers ### Can you use protease and palmitoyl tripeptide-1 together? Keep [protease](https://lovi.care/skincare/ae/ingredients/protease) and [palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/palmitoyl-tripeptide-1) apart because enzymes degrade peptides and render them inactive. ### Which goes first, protease or palmitoyl tripeptide-1? Keep protease and palmitoyl tripeptide-1 apart by using them in separate routines because proteolytic enzymes may degrade cosmetic peptides and render them inactive. ### Are protease and palmitoyl tripeptide-1 good for sensitive skin? Keep protease and palmitoyl tripeptide-1 apart in your routine because the enzyme degrades the peptide bonds and renders the active inactive. ## Research on protease and palmitoyl tripeptide-1 - [Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913](https://pubmed.ncbi.nlm.nih.gov/29146927/) Protease · Scientific Reports, 2017 - [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2015 - [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026 - [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026 ## Other combinations - Keep them apart: [Adapalene and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/adapalene-and-palmitoyl-tripeptide-1) - Keep them apart: [Granactive retinoid and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/granactive-retinoid-and-palmitoyl-tripeptide-1) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-tripeptide-1) - Keep them apart: [Pro-retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/pro-retinol-and-palmitoyl-tripeptide-1) - Keep them apart: [Retinal and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/retinal-and-palmitoyl-tripeptide-1) - Keep them apart: [Retinoid blend and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/retinoid-blend-and-palmitoyl-tripeptide-1) - Depends on the strength: [Retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/retinol-and-palmitoyl-tripeptide-1) - Keep them apart: [Tretinoin and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/tretinoin-and-palmitoyl-tripeptide-1) - Keep them apart: [Vitamin A and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/vitamin-a-and-palmitoyl-tripeptide-1) - Work well together: [Liposome and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/liposome-and-palmitoyl-tripeptide-1) - Work well together: [Microcapsule and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/microcapsule-and-palmitoyl-tripeptide-1) - Depends on the strength: [Vitamin C and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/vitamin-c-and-palmitoyl-tripeptide-1) - Work well together: [Betaine and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/betaine-and-palmitoyl-tripeptide-1) - Work well together: [Glycerin and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/glycerin-and-palmitoyl-tripeptide-1) - Work well together: [Hyaluronic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/hyaluronic-acid-and-palmitoyl-tripeptide-1) - Depends on the strength: [Niacinamide and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/niacinamide-and-palmitoyl-tripeptide-1) - Work well together: [Panthenol and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/panthenol-and-palmitoyl-tripeptide-1) - Work well together: [Bakuchiol and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/bakuchiol-and-palmitoyl-tripeptide-1) - Work well together: [Arginine and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/arginine-and-palmitoyl-tripeptide-1) - Work well together: [GABA and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/gaba-and-palmitoyl-tripeptide-1) - Work well together: [Silk amino acids and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/silk-amino-acids-and-palmitoyl-tripeptide-1) - Work well together: [Taurine and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/taurine-and-palmitoyl-tripeptide-1) - Work well together: [Palmitoyl tripeptide-1 and theanine](https://lovi.care/skincare/ae/ingredients/palmitoyl-tripeptide-1-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-tripeptide-1) - Keep them apart: [Citric acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/citric-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Glycolic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/glycolic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Lactic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/lactic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Mandelic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/mandelic-acid-and-palmitoyl-tripeptide-1) - Work well together: [Coenzyme Q10 and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/coenzyme-q10-and-palmitoyl-tripeptide-1) - Work well together: [Green tea and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/green-tea-and-palmitoyl-tripeptide-1) - Work well together: [Vitamin E and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/vitamin-e-and-palmitoyl-tripeptide-1) - Work well together: [Beta-sitosterol and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/beta-sitosterol-and-palmitoyl-tripeptide-1) - Work well together: [Ceramide-building complex and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/ceramide-building-complex-and-palmitoyl-tripeptide-1) - Work well together: [Cholesterol and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/cholesterol-and-palmitoyl-tripeptide-1) - Work well together: [Phytosphingosine and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1) - Work well together: [Phytosterol and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/phytosterol-and-palmitoyl-tripeptide-1) - Work well together: [Squalene and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/squalene-and-palmitoyl-tripeptide-1) - Work well together: [Tri-ceramide complex and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/tri-ceramide-complex-and-palmitoyl-tripeptide-1) - Keep them apart: [Salicylic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/salicylic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Baking soda and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/baking-soda-and-palmitoyl-tripeptide-1) - Keep them apart: [Bleach and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/bleach-and-palmitoyl-tripeptide-1) - Keep them apart: [Potassium hydroxide and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/potassium-hydroxide-and-palmitoyl-tripeptide-1) - Keep them apart: [Behenyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/behenyl-alcohol-and-palmitoyl-tripeptide-1) - Keep them apart: [Isopropyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/isopropyl-alcohol-and-palmitoyl-tripeptide-1) - Keep them apart: [Polyvinyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/polyvinyl-alcohol-and-palmitoyl-tripeptide-1) - Keep them apart: [Copper and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/copper-and-palmitoyl-tripeptide-1) - Keep them apart: [Benzoyl peroxide and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/benzoyl-peroxide-and-palmitoyl-tripeptide-1) - Keep them apart: [Magnesium and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/magnesium-and-palmitoyl-tripeptide-1) - Keep them apart: [Zinc and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/zinc-and-palmitoyl-tripeptide-1) - Keep them apart: [Zinc sulfate and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/zinc-sulfate-and-palmitoyl-tripeptide-1) - Keep them apart: [Azelaic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/azelaic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3-and-protease) - Keep them apart: [Bio-placenta peptides and protease](https://lovi.care/skincare/ae/ingredients/bio-placenta-peptides-and-protease) - Keep them apart: [Collagen peptide and protease](https://lovi.care/skincare/ae/ingredients/collagen-peptide-and-protease) - Keep them apart: [Copper peptide and protease](https://lovi.care/skincare/ae/ingredients/copper-peptide-and-protease) - Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ae/ingredients/hexapeptide-and-protease) - Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/ae/ingredients/hexapeptide-9-and-protease) - Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/ae/ingredients/protease-and-palmitoyl-pentapeptide-4) - Keep them apart: [Superoxide dismutase and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/superoxide-dismutase-and-palmitoyl-tripeptide-1) - Keep them apart: [Peptide-rich plasma and protease](https://lovi.care/skincare/ae/ingredients/peptide-rich-plasma-and-protease) - Keep them apart: [Protease and triple peptide blend](https://lovi.care/skincare/ae/ingredients/protease-and-triple-peptide-blend) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/protease-and-palmitoyl-tripeptide-1 - United Kingdom: https://lovi.care/skincare/uk/ingredients/protease-and-palmitoyl-tripeptide-1 - Ireland: https://lovi.care/skincare/ie/ingredients/protease-and-palmitoyl-tripeptide-1 - Germany: https://lovi.care/skincare/de/ingredients/protease-and-palmitoyl-tripeptide-1 - France: https://lovi.care/skincare/fr/ingredients/protease-and-palmitoyl-tripeptide-1 - Italy: https://lovi.care/skincare/it/ingredients/protease-and-palmitoyl-tripeptide-1 - Netherlands: https://lovi.care/skincare/nl/ingredients/protease-and-palmitoyl-tripeptide-1 - Spain: https://lovi.care/skincare/es/ingredients/protease-and-palmitoyl-tripeptide-1 - Canada: https://lovi.care/skincare/ca/ingredients/protease-and-palmitoyl-tripeptide-1 - Australia: https://lovi.care/skincare/au/ingredients/protease-and-palmitoyl-tripeptide-1 - Singapore: https://lovi.care/skincare/sg/ingredients/protease-and-palmitoyl-tripeptide-1 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/protease-and-palmitoyl-tripeptide-1 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/protease-and-palmitoyl-tripeptide-1 (this page)