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Niacinamide and lipohydroxy acid

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Niacinamide and lipohydroxy acid: keep them apart

Keep them apart

Use them at different times of day, applying the hydroxy acid first and niacinamide later, because combining them causes irritation. Using both at once overloads your skin with too much exfoliation and activity, leading to redness and dryness. To fix this, you can leave more time between applications or switch to a gentler product.

Niacinamide products

Lipohydroxy acid products

Questions and answers

Can you use niacinamide and lipohydroxy acid together?

Keep niacinamide and lipohydroxy acid apart by using one active per routine phase because combining them may overload the skin with redness and dryness. Products like La Roche-Posay Effaclar Clarifying Solution and La Roche-Posay Effaclar Ultra Concentrated Serum contain both ingredients.

Which goes first, niacinamide or lipohydroxy acid?

Keep niacinamide and lipohydroxy acid apart by using them in separate routine phases to avoid overloading your skin. Products like La Roche-Posay Effaclar Clarifying Solution and La Roche-Posay Effaclar Ultra Concentrated Serum contain both ingredients, so they should be applied at different times of day.

Are niacinamide and lipohydroxy acid good for sensitive skin?

Keep niacinamide and lipohydroxy acid apart by using one active per routine phase, as combining them may overload the skin with redness and dryness.

Research on niacinamide and lipohydroxy acid

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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