# Niacinamide and hydroxypinacolone retinoate Page: https://lovi.care/skincare/ae/ingredients/niacinamide-and-hydroxypinacolone-retinoate The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates. Depends on the strength Use them at different times of day, applying [niacinamide](https://lovi.care/skincare/ae/ingredients/niacinamide) in the morning and the retinoid at night, because their combined strength can cause irritation. Niacinamide helps calm and protect the skin, while [hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate) speeds up cell renewal. If they clash on the skin, it can lead to redness and dryness, so the shopper can switch to a gentler product strength or use them on alternate nights. [Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects](https://pubmed.ncbi.nlm.nih.gov/28318351/) [Why Topical Retinoids Are Mainstay of Therapy for Acne](https://pubmed.ncbi.nlm.nih.gov/28585191/) - [All about niacinamide](https://lovi.care/skincare/ae/ingredients/niacinamide) - [All about hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate) ### [Niacinamide](https://lovi.care/skincare/ae/ingredients/niacinamide) products - [La Roche-Posay Toleriane Double Repair Face Moisturizer](https://lovi.care/skincare/ae/p/la-roche-posay/toleriane-double-repair-face-moisturizer/for/oily-acne-prone-skin) — High fit - [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ae/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — [AED 49.95 at Amazon](https://www.amazon.ae/dp/B07C5XD33D?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [Cetaphil Gentle Skin Cleanser](https://lovi.care/skincare/ae/p/cetaphil/gentle-skin-cleanser/for/dry-skin) — Superior fit — [AED 44.60 at Amazon](https://www.amazon.ae/dp/B09ZFCJ963?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [La Roche-Posay Toleriane Hydrating Gentle Cleanser](https://lovi.care/skincare/ae/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — [AED 74.76 at Amazon](https://www.amazon.ae/dp/B009C5NAJC?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [Dr. Althea 345 Relief Cream](https://lovi.care/skincare/ae/p/dr-althea/345-relief-cream/for/acne-prone-skin) — Superior fit — [AED 54.05 at Amazon](https://www.amazon.ae/dp/B07PK2P2XB?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [Biodance Bio-Collagen Real Deep Mask](https://lovi.care/skincare/ae/p/biodance/bio-collagen-real-deep-mask/for/mature-skin) — Superior fit — [AED 35.15 at Amazon](https://www.amazon.ae/dp/B0B2RM68G2?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [Olay Regenerist Micro-Sculpting Cream](https://lovi.care/skincare/ae/p/olay/regenerist-micro-sculpting-cream/for/mature-skin) — Superior fit — [AED 88.09 at Amazon](https://www.amazon.ae/dp/B078LSV2RL?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [CeraVe Resurfacing Retinol Serum](https://lovi.care/skincare/ae/p/cerave/resurfacing-retinol-serum/for/dark-spots) — High fit — [AED 60.50 at Amazon](https://www.amazon.ae/dp/B07VWSN95S?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/ae/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit - [Medicube PDRN Pink Peptide Serum](https://lovi.care/skincare/ae/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [AED 35.00 at Amazon](https://www.amazon.ae/dp/B0DBF65JYY?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [CeraVe Renewing SA Cleanser](https://lovi.care/skincare/ae/p/cerave/renewing-sa-cleanser/for/oily-acne-prone-skin) — High fit — [AED 51.95 at Amazon](https://www.amazon.ae/dp/B00U1YCRD8?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [Medicube Collagen Jelly Cream](https://lovi.care/skincare/ae/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [AED 37.99 at Amazon](https://www.amazon.ae/dp/B0CM2PPNMW?tag=lovi00-21&linkCode=osi&th=1&psc=1) ### [Hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate) products - [The Ordinary Granactive Retinoid 2% Emulsion](https://lovi.care/skincare/ae/p/the-ordinary/granactive-retinoid-2-emulsion/for/oily-skin) — High fit - [IOPE Retinol Super Bounce Serum](https://lovi.care/skincare/ae/p/iope/retinol-super-bounce-serum/for/dark-spots) — Average fit — [AED 267.00 at Amazon](https://www.amazon.ae/dp/B0CK4PZ38Z?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [BYOMA Sensitive Retinol Oil](https://lovi.care/skincare/ae/p/byoma/sensitive-retinol-oil/for/dry-skin) — Average fit — [AED 52.99 at Amazon](https://www.amazon.ae/dp/B0CSDWY381?tag=lovi00-21&linkCode=osi&th=1&psc=1) - [Sunday Riley A+ High-Dose Retinoid Serum](https://lovi.care/skincare/ae/p/sunday-riley/a-high-dose-retinoid-serum/for/oily-acne-prone-skin) — High fit — [AED 198.61 at Amazon](https://www.amazon.ae/dp/B0B7JT39KP?tag=lovi00-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use niacinamide and hydroxypinacolone retinoate together? Yes, you can use [niacinamide](https://lovi.care/skincare/ae/ingredients/niacinamide) and [hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate) together depending on the strength, and you can find both ingredients in Medicube Deep Vita A [Retinol](https://lovi.care/skincare/ae/ingredients/retinol) [Serum](https://lovi.care/skincare/ae/ingredients/serum). Niacinamide helps stabilize the skin barrier and reduces irritation when paired with low percentages of retinoids. ### Which goes first, niacinamide or hydroxypinacolone retinoate? Whether niacinamide or hydroxypinacolone retinoate goes first depends on the product strength, and you can find both ingredients together in Medicube Deep Vita A Retinol Serum. Using niacinamide in the morning and the retinoid at night helps avoid irritation. ### Are niacinamide and hydroxypinacolone retinoate good for sensitive skin? Yes, niacinamide and hydroxypinacolone retinoate depend on the strength, and you can use niacinamide in the morning and the retinoid at night. Medicube Deep Vita A Retinol Serum contains both ingredients. ## Research on niacinamide and hydroxypinacolone retinoate - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021 - [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021 - [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024 - [Characterization of Acne-Prone Skin with Reflectance Confocal Microscopy and Optical Coherence Tomography and Modifications Induced by Topical Treatment and Probiotic Supplementation](https://pubmed.ncbi.nlm.nih.gov/37510902/) Hydroxypinacolone retinoate · Journal of Clinical Medicine, 2023 - [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023 - [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025 ## Other combinations - Depends on the strength: [Retinol and niacinamide](https://lovi.care/skincare/ae/ingredients/retinol-and-niacinamide) - Depends on the strength: [AHA blend glycolic and citric acids and niacinamide](https://lovi.care/skincare/ae/ingredients/aha-blend-glycolic-and-citric-acids-and-niacinamide) - Depends on the strength: [Niacinamide and citric acid](https://lovi.care/skincare/ae/ingredients/niacinamide-and-citric-acid) - Depends on the strength: [Glycolic acid and niacinamide](https://lovi.care/skincare/ae/ingredients/glycolic-acid-and-niacinamide) - Depends on the strength: [Niacinamide and lactic acid](https://lovi.care/skincare/ae/ingredients/niacinamide-and-lactic-acid) - Depends on the strength: [Niacinamide and mandelic acid](https://lovi.care/skincare/ae/ingredients/niacinamide-and-mandelic-acid) - Depends on the strength: [Niacinamide and salicylic acid](https://lovi.care/skincare/ae/ingredients/niacinamide-and-salicylic-acid) - Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate) - Keep them apart: [Bio-placenta peptides and hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate) - Keep them apart: [Hydroxypinacolone retinoate and collagen peptide](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate-and-collagen-peptide) - Keep them apart: [Hydroxypinacolone retinoate and copper peptide](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate-and-copper-peptide) - Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/hexapeptide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-tripeptide-1) - Keep them apart: [Hydroxypinacolone retinoate and peptide-rich plasma](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate-and-peptide-rich-plasma) - Keep them apart: [Hydroxypinacolone retinoate and triple peptide blend](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate-and-triple-peptide-blend) - Depends on the strength: [Niacinamide and gluconolactone](https://lovi.care/skincare/ae/ingredients/niacinamide-and-gluconolactone) - Depends on the strength: [Niacinamide and lactobionic acid](https://lovi.care/skincare/ae/ingredients/niacinamide-and-lactobionic-acid) - Work well together: [Niacinamide and cholesterol](https://lovi.care/skincare/ae/ingredients/niacinamide-and-cholesterol) - Work well together: [Niacinamide and lauric acid](https://lovi.care/skincare/ae/ingredients/niacinamide-and-lauric-acid) - Work well together: [Niacinamide and linoleic acid](https://lovi.care/skincare/ae/ingredients/niacinamide-and-linoleic-acid) - Work well together: [Niacinamide and tri-ceramide complex](https://lovi.care/skincare/ae/ingredients/niacinamide-and-tri-ceramide-complex) - Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/ae/ingredients/adapalene-and-niacinamide) - Depends on the strength: [Niacinamide and granactive retinoid](https://lovi.care/skincare/ae/ingredients/niacinamide-and-granactive-retinoid) - Depends on the strength: [Niacinamide and pro-retinol](https://lovi.care/skincare/ae/ingredients/niacinamide-and-pro-retinol) - Depends on the strength: [Niacinamide and retinal](https://lovi.care/skincare/ae/ingredients/niacinamide-and-retinal) - Depends on the strength: [Niacinamide and retinoid blend](https://lovi.care/skincare/ae/ingredients/niacinamide-and-retinoid-blend) - Depends on the strength: [Niacinamide and tretinoin](https://lovi.care/skincare/ae/ingredients/niacinamide-and-tretinoin) - Depends on the strength: [Niacinamide and vitamin A](https://lovi.care/skincare/ae/ingredients/niacinamide-and-vitamin-a) - Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/ae/ingredients/niacinamide-and-acetyl-hexapeptide-3) - Depends on the strength: [Niacinamide and bio-placenta peptides](https://lovi.care/skincare/ae/ingredients/niacinamide-and-bio-placenta-peptides) - Depends on the strength: [Niacinamide and collagen peptide](https://lovi.care/skincare/ae/ingredients/niacinamide-and-collagen-peptide) - Depends on the strength: [Niacinamide and copper peptide](https://lovi.care/skincare/ae/ingredients/niacinamide-and-copper-peptide) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/ae/ingredients/niacinamide-and-hexapeptide) - Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/ae/ingredients/niacinamide-and-hexapeptide-9) - Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/ae/ingredients/niacinamide-and-palmitoyl-pentapeptide-4) - Depends on the strength: [Niacinamide and palmitoyl tripeptide-1](https://lovi.care/skincare/ae/ingredients/niacinamide-and-palmitoyl-tripeptide-1) - Depends on the strength: [Niacinamide and peptide-rich plasma](https://lovi.care/skincare/ae/ingredients/niacinamide-and-peptide-rich-plasma) - Depends on the strength: [Niacinamide and triple peptide blend](https://lovi.care/skincare/ae/ingredients/niacinamide-and-triple-peptide-blend) - Work well together: [Niacinamide and hyaluronic acid](https://lovi.care/skincare/ae/ingredients/niacinamide-and-hyaluronic-acid) - Keep them apart: [AHA blend glycolic and citric acids and hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/aha-blend-glycolic-and-citric-acids-and-hydroxypinacolone-retinoate) - Keep them apart: [Hydroxypinacolone retinoate and citric acid](https://lovi.care/skincare/ae/ingredients/hydroxypinacolone-retinoate-and-citric-acid) - Keep them apart: [Glycolic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate) - Keep them apart: [Lactic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/lactic-acid-and-hydroxypinacolone-retinoate) - Keep them apart: [Mandelic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/mandelic-acid-and-hydroxypinacolone-retinoate) - Work well together: [Niacinamide and bakuchiol](https://lovi.care/skincare/ae/ingredients/niacinamide-and-bakuchiol) - Keep them apart: [Salicylic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/salicylic-acid-and-hydroxypinacolone-retinoate) - Keep them apart: [Vitamin C and hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/vitamin-c-and-hydroxypinacolone-retinoate) - Work well together: [Niacinamide and zinc](https://lovi.care/skincare/ae/ingredients/niacinamide-and-zinc) - Work well together: [Niacinamide and zinc gluconate](https://lovi.care/skincare/ae/ingredients/niacinamide-and-zinc-gluconate) - Work well together: [Niacinamide and zinc oxide](https://lovi.care/skincare/ae/ingredients/niacinamide-and-zinc-oxide) - Work well together: [Niacinamide and zinc sulfate](https://lovi.care/skincare/ae/ingredients/niacinamide-and-zinc-sulfate) - Work well together: [Benzoyl peroxide and niacinamide](https://lovi.care/skincare/ae/ingredients/benzoyl-peroxide-and-niacinamide) - Keep them apart: [Niacinamide and lipohydroxy acid](https://lovi.care/skincare/ae/ingredients/niacinamide-and-lipohydroxy-acid) - Keep them apart: [Benzoyl peroxide and hydroxypinacolone retinoate](https://lovi.care/skincare/ae/ingredients/benzoyl-peroxide-and-hydroxypinacolone-retinoate) - Work well together: [Ferulic acid and niacinamide](https://lovi.care/skincare/ae/ingredients/ferulic-acid-and-niacinamide) - Work well together: [Green tea and niacinamide](https://lovi.care/skincare/ae/ingredients/green-tea-and-niacinamide) - Work well together: [Niacinamide and vitamin E](https://lovi.care/skincare/ae/ingredients/niacinamide-and-vitamin-e) - Keep them apart: [Niacinamide and isopropyl alcohol](https://lovi.care/skincare/ae/ingredients/niacinamide-and-isopropyl-alcohol) - Work well together: [Niacinamide and ascorbyl glucoside](https://lovi.care/skincare/ae/ingredients/niacinamide-and-ascorbyl-glucoside) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/niacinamide-and-hydroxypinacolone-retinoate - United Kingdom: https://lovi.care/skincare/uk/ingredients/niacinamide-and-hydroxypinacolone-retinoate - Ireland: https://lovi.care/skincare/ie/ingredients/niacinamide-and-hydroxypinacolone-retinoate - Germany: https://lovi.care/skincare/de/ingredients/niacinamide-and-hydroxypinacolone-retinoate - France: https://lovi.care/skincare/fr/ingredients/niacinamide-and-hydroxypinacolone-retinoate - Italy: https://lovi.care/skincare/it/ingredients/niacinamide-and-hydroxypinacolone-retinoate - Netherlands: https://lovi.care/skincare/nl/ingredients/niacinamide-and-hydroxypinacolone-retinoate - Spain: https://lovi.care/skincare/es/ingredients/niacinamide-and-hydroxypinacolone-retinoate - Canada: https://lovi.care/skincare/ca/ingredients/niacinamide-and-hydroxypinacolone-retinoate - Australia: https://lovi.care/skincare/au/ingredients/niacinamide-and-hydroxypinacolone-retinoate - Singapore: https://lovi.care/skincare/sg/ingredients/niacinamide-and-hydroxypinacolone-retinoate - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/niacinamide-and-hydroxypinacolone-retinoate - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/niacinamide-and-hydroxypinacolone-retinoate (this page)