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Adapalene and benzoyl peroxide

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Adapalene and benzoyl peroxide: keep them apart

Keep them apart

Use them at different times of day, applying benzoyl peroxide in the morning and adapalene at night, because they cancel each other out. Benzoyl peroxide breaks down the adapalene, which makes it less effective and can cause extra dryness and irritation on the skin. You can switch to a gentler strength, or wait a few minutes and use a good moisturizer between them.

Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effectsWhy Topical Retinoids Are Mainstay of Therapy for Acne

Adapalene products

Benzoyl peroxide products

Questions and answers

Can you use adapalene and benzoyl peroxide together?

Keep adapalene and benzoyl peroxide apart because benzoyl peroxide causes oxidation and deactivation of retinoids. You can find both ingredients together in finished products like Galderma Epiduo Gel.

Which goes first, adapalene or benzoyl peroxide?

Keep adapalene and benzoyl peroxide apart because benzoyl peroxide can oxidize and deactivate retinoids, so use benzoyl peroxide in the morning and adapalene at night, or use products like Galderma Epiduo Gel.

Are adapalene and benzoyl peroxide good for sensitive skin?

Keep adapalene and benzoyl peroxide apart because benzoyl peroxide can oxidize and deactivate retinoids. You can use benzoyl peroxide in the morning and adapalene in the evening to avoid irritation.

Research on adapalene and benzoyl peroxide

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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