# Sesderma vs Bepantol Page: https://lovi.care/skincare/ae/compare/sesderma-vs-bepantol The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates. Sesderma and Bepantol are two established European skincare lines offering distinct approaches to daily care. The Spanish brand, founded in 1989 and owned by Grupo Sesderma since 2026, is beloved for its advanced [serums](https://lovi.care/skincare/ae/ingredients/serum) and meticulously engineered formulas, such as the Azelac RU Serum, which suit sensitive, hyperpigmented, and aging skin types best. Meanwhile, the Swiss brand, founded in 1944 and owned by Bayer AG since 2005, is widely loved for its nourishing moisturizers and thoughtful formulas, including the Derma line, which suit dry, sensitive, and irritated skin best. While both cater well to sensitive skin, they differ because botanical [extracts](https://lovi.care/skincare/ae/ingredients/extract) and active compounds in the former refine skin texture and promote a radiant complexion, whereas the offerings of the latter provide gentle, reliable care for daily routines. Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026. [skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html) Bepantol is a Swiss skincare brand founded in 1944 and owned by Bayer AG since 2005. [en.wikipedia.org](https://en.wikipedia.org/wiki/Bayer) This page compares some of the most popular Sesderma and Bepantol products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg1f6e5f68b2). ### Popular Sesderma vs Bepantol products #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [AED 123.63 at Amazon](https://www.amazon.ae/dp/B00987RKWW?tag=lovi00-21&linkCode=osi&th=1&psc=1) #### Bepantol - [Derma](https://lovi.care/skincare/ae/p/bepantol/derma/for/sensitive-skin) — Average fit ## Questions and answers ### Sesderma or Bepantol: which is better? Sesderma offers a High Lovi fit for acne-prone skin and dark spots with its Azelac RU [Serum](https://lovi.care/skincare/ae/ingredients/serum), whereas Bepantol Derma provides only an Average fit for those concerns. Azelac RU Serum contains fragrance, while the products on this page for Bepantol list no fragrance. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### What is the difference between Sesderma and Bepantol? Sesderma offers the Azelac RU Serum, which achieves a High Lovi fit for acne-prone skin and skin with dark spots, while Bepantol features the Derma moisturizer, which reaches an Average Lovi fit for sensitive and dry skin. The products on this page from Sesderma contain fragrance, whereas every Bepantol product on this page lists no fragrance. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### Which is more affordable, Sesderma or Bepantol? This page does not compare the prices or affordability of Sesderma and Bepantol. For skin type fit, Lovi rates Sesderma's Azelac RU Serum as High for acne-prone skin, while Bepantol Derma is rated Average for dry skin. ### Which causes fewer breakouts, Sesderma or Bepantol? Sesderma fits acne-prone skin with a High Lovi level for its Azelac RU Serum, whereas Bepantol's Derma moisturizer only reaches an Average fit for acne-prone skin. [Azelaic acid](https://lovi.care/skincare/ae/ingredients/azelaic-acid) helps target acne symptoms. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### When were Sesderma and Bepantol founded and in which countries? Sesderma was founded in 1989 in Spain, while Bepantol was founded in 1944 in Switzerland. ### Which company owns Bepantol and when was it acquired? Bepantol was founded in Switzerland in 1944 and has been owned by Bayer AG since 2005. ### Do Sesderma products contain fragrance compared to Bepantol? Sesderma includes fragrance in its Azelac RU Serum on this page, whereas Bepantol products on this page list no fragrance in their ingredients. ## Research behind their key ingredients - [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000 - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002 - [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007 - [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007 - [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017 - [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998 - [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 - [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024 ## The brands - Spanish skincare: [Sesderma](https://lovi.care/skincare/ae/brands/sesderma) - Swiss skincare: [Bepantol](https://lovi.care/skincare/ae/brands/bepantol) ## More comparisons - [SKIN1004 vs Sesderma](https://lovi.care/skincare/ae/compare/skin1004-vs-sesderma) - [SKIN1004 vs Bepantol](https://lovi.care/skincare/ae/compare/skin1004-vs-bepantol) - [Anua vs Sesderma](https://lovi.care/skincare/ae/compare/anua-vs-sesderma) - [Anua vs Bepantol](https://lovi.care/skincare/ae/compare/anua-vs-bepantol) - [Medicube vs Sesderma](https://lovi.care/skincare/ae/compare/medicube-vs-sesderma) - [Medicube vs Bepantol](https://lovi.care/skincare/ae/compare/medicube-vs-bepantol) - [The Ordinary vs Sesderma](https://lovi.care/skincare/ae/compare/the-ordinary-vs-sesderma) - [The Ordinary vs Bepantol](https://lovi.care/skincare/ae/compare/the-ordinary-vs-bepantol) - [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/ae/compare/beauty-of-joseon-vs-sesderma) - [Beauty of Joseon vs Bepantol](https://lovi.care/skincare/ae/compare/beauty-of-joseon-vs-bepantol) - [COSRX vs Sesderma](https://lovi.care/skincare/ae/compare/cosrx-vs-sesderma) - [COSRX vs Bepantol](https://lovi.care/skincare/ae/compare/cosrx-vs-bepantol) - [CeraVe vs Sesderma](https://lovi.care/skincare/ae/compare/cerave-vs-sesderma) - [CeraVe vs Bepantol](https://lovi.care/skincare/ae/compare/cerave-vs-bepantol) - [La Roche-Posay vs Sesderma](https://lovi.care/skincare/ae/compare/la-roche-posay-vs-sesderma) - [La Roche-Posay vs Bepantol](https://lovi.care/skincare/ae/compare/la-roche-posay-vs-bepantol) - [Dr. Althea vs Sesderma](https://lovi.care/skincare/ae/compare/dr-althea-vs-sesderma) - [Dr. Althea vs Bepantol](https://lovi.care/skincare/ae/compare/dr-althea-vs-bepantol) - [Some By Mi vs Sesderma](https://lovi.care/skincare/ae/compare/some-by-mi-vs-sesderma) - [Some By Mi vs Bepantol](https://lovi.care/skincare/ae/compare/some-by-mi-vs-bepantol) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/sesderma-vs-bepantol - United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-bepantol - Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-bepantol - Germany: https://lovi.care/skincare/de/compare/sesderma-vs-bepantol - France: https://lovi.care/skincare/fr/compare/sesderma-vs-bepantol - Italy: https://lovi.care/skincare/it/compare/sesderma-vs-bepantol - Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-bepantol - Spain: https://lovi.care/skincare/es/compare/sesderma-vs-bepantol - Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-bepantol - Australia: https://lovi.care/skincare/au/compare/sesderma-vs-bepantol - Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-bepantol - Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-bepantol - United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-bepantol (this page)