REN Clean Skincare vs Sebamed

Questions and answers

Research behind their key ingredients

• Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

  Sodium hyaluronate · Dermatologic Therapy, 2022

• Topical use of dexpanthenol in skin disorders

  Panthenol · American Journal of Clinical Dermatology, 2002

• The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction

  Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016

• Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations

  Aloe barbadensis leaf juice · Clinical Pharmacology, 2018

• The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

  Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017

• A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora

  Panthenol · The Journal of Dermatological Treatment, 2017

• Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial

  Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

• High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin

  Witch hazel bark extract · Phytochemistry, 2001

• Double-blind, randomized, placebo-controlled study of a lotion containing triethyl citrate and ethyl linoleate in the treatment of acne vulgaris

  Triethyl citrate · The British Journal of Dermatology, 2007

• Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison

  Salix nigra bark extract willow bark extract · Journal of Cosmetic Dermatology, 2019

• Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract

  Salix nigra bark extract willow bark extract · Planta Medica, 2019

• An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging

  Salix nigra bark extract willow bark extract · Journal of Cosmetic Dermatology, 2010

• Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol

  Sorbitol · Journal of Cosmetic Science, 2013

• Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study

  Panthenol · Journal of Cosmetic Dermatology, 2025

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.