# Medicube vs MAC

Page: https://lovi.care/skincare/ae/compare/medicube-vs-mac

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Medicube and MAC are distinct beauty brands, with the former being a Korean skincare line founded in 2016 and the latter a Canadian label established in 1984. The first brand is revered for its curated selection of moisturizers, [serums](https://lovi.care/skincare/ae/ingredients/serum), toners, and masks featuring [niacinamide](https://lovi.care/skincare/ae/ingredients/niacinamide), [collagen](https://lovi.care/skincare/ae/ingredients/collagen), and [hyaluronic acid](https://lovi.care/skincare/ae/ingredients/hyaluronic-acid), suiting oily acne-prone and oily skin best by balancing excess sebum and hydration. Conversely, the Canadian label is beloved for its thoughtful approach to daily skincare, offering reliable moisturizers and makeup removers crafted from carefully balanced formulas that suit balanced skin best. While both offer targeted solutions for various skin concerns, they differ fundamentally in their foundational ingredients, regional origins, and ideal skin types.

Medicube is a Korean skincare brand founded in 2016 and owned by APR Corp..

[medicubereviews.co.uk](https://medicubereviews.co.uk/medicube/story/) [glossy.co](https://www.glossy.co/beauty/medicubes-founder-on-the-products-and-people-that-fueled-the-k-beauty-brands-booming-year/)

MAC is a Canadian skincare brand founded in 1984 and owned by The Estée Lauder Companies Inc. since 1994.

[elcompanies.com](https://www.elcompanies.com/en-gb/our-brands/mac) [en.wikipedia.org](https://en.wikipedia.org/wiki/Est%C3%A9e_Lauder_Companies)

This page compares some of the most popular Medicube and MAC products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pga9a9c2d624).

### Popular Medicube vs MAC products

#### Medicube

- [Zero Pore Pad](https://lovi.care/skincare/ae/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [AED 41.99 at Amazon](https://www.amazon.ae/dp/B0CW1KV8B6?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [PDRN Pink Peptide Serum](https://lovi.care/skincare/ae/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [AED 35.00 at Amazon](https://www.amazon.ae/dp/B0DBF65JYY?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [Collagen Jelly Cream](https://lovi.care/skincare/ae/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [AED 37.99 at Amazon](https://www.amazon.ae/dp/B0CM2PPNMW?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [Collagen Night Wrapping Mask](https://lovi.care/skincare/ae/p/medicube/collagen-night-wrapping-mask/for/dry-skin) — High fit — [AED 35.00 at Amazon](https://www.amazon.ae/dp/B0BRMYHMS5?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [PDRN Pink Collagen Gel Mask](https://lovi.care/skincare/ae/p/medicube/pdrn-pink-collagen-gel-mask/for/dry-sensitive-skin) — High fit — [AED 35.00 at Amazon](https://www.amazon.ae/dp/B0DGTMR754?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [DEEP VITA-C CAPSULE CREAM](https://lovi.care/skincare/ae/p/medicube/deep-vita-c-capsule-cream/for/sensitive-skin) — Average fit — [AED 44.79 at Amazon](https://www.amazon.ae/dp/B0D2Z3GGCY?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [TRIPLE COLLAGEN CREAM](https://lovi.care/skincare/ae/p/medicube/triple-collagen-cream/for/mature-skin) — Average fit — [AED 45.99 at Amazon](https://www.amazon.ae/dp/B0BPXT3GBN?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [Zero Foam Cleanser](https://lovi.care/skincare/ae/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [AED 38.99 at Amazon](https://www.amazon.ae/dp/B09C1B7BH5?tag=lovi00-21&linkCode=osi&th=1&psc=1)

#### MAC

- [Hyper Real Serumizer](https://lovi.care/skincare/ae/p/mac/hyper-real-serumizer/for/dry-sensitive-skin) — High fit — [AED 182.48 at Amazon](https://www.amazon.ae/dp/B0BV14LWTN?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [Mineralize Timecheck Lotion](https://lovi.care/skincare/ae/p/mac/mineralize-timecheck-lotion/for/dry-skin) — High fit
- [Hyper Real Fresh Canvas Cleansing Oil](https://lovi.care/skincare/ae/p/mac/hyper-real-fresh-canvas-cleansing-oil/for/dry-sensitive-skin) — High fit

## People Say

Medicube

MAC

- Hydration and Moisture Mostly Mentioned Mostly Mentioned “skin feels bouncier and hydrated — Medicube PDRN Pink Peptide Serum” “gave me instant glass skin — Medicube Collagen Jelly Cream” “absorbs quickly — MAC Hyper Real Serumizer” “lit-from-within look — MAC Hyper Real Serumizer”
- Makeup Base and Primer Not noted Mostly Mentioned “foundation glides on — MAC Hyper Real Serumizer” “Sits beautifully under makeup — MAC Mineralize Timecheck Lotion”
- Soothing and Gentle Formulas Often Mentioned Often Mentioned “refreshing sensation — Medicube PDRN Pink Collagen Gel Mask” “calming the skin — Medicube Red Succinic Acid Peeling Pad” “Does not cause breakouts — MAC Mineralize Timecheck Lotion” “Doesn't sting my eyes or blur my vision. — MAC Hyper Real Fresh Canvas Cleansing Oil”
- Skin Texture Improvement Often Mentioned Sometimes Noted “gives my skin a smooth, glass-like finish — Medicube Zero Pore Pad” “skin feels smoother — Medicube PDRN Pink Peptide Serum” “skin feels baby soft — Medicube Zero Pore Blackhead Mud Mask” “petal-soft skin — MAC Hyper Real Serumizer”
- Pore Appearance Reduction Rarely Noted Often Mentioned “Reduces appearance of pores — MAC Mineralize Timecheck Lotion” “noticed a real difference in pore visibility — Medicube Zero Pore Pad”
- High Price Point Sometimes Noted Mostly Mentioned “price is steep — Medicube PDRN Pink Collagen Gel Mask” “price is a bit steep — Medicube Red Succinic Acid Peeling Pad” “Wish it was more affordable — Medicube Zero Foam Cleanser” “too expensive — MAC Hyper Real Serumizer”
- Strong Fragrance and Scent Often Mentioned Often Mentioned “slightly fishy smell — Medicube PDRN Pink Peptide Serum” “smells like old lady perfume — Medicube Collagen Jelly Cream” “scent is overpowering — MAC Hyper Real Serumizer” “Has a scent that might irritate very sensitive noses. — MAC Hyper Real Fresh Canvas Cleansing Oil”
- Breakouts and Skin Irritation Often Mentioned Sometimes Noted “caused acne — MAC Hyper Real Serumizer” “Breaks me out, I got pimples from this. — MAC Hyper Real Fresh Canvas Cleansing Oil” “Stings if it accidentally gets into the eyes. — MAC Hyper Real Fresh Canvas Cleansing Oil” “caused redness and sensitivity — Medicube Zero Pore Pad”
- Sticky Residue and Finish Often Mentioned Not noted “hair sticks to my face — Medicube Collagen Jelly Cream”

## Questions and answers

### Medicube or MAC: which is better?

Medicube helps improve skin texture and hydration better, while MAC is preferred for makeup bases and primers. The products on this page feature key ingredients like [niacinamide](https://lovi.care/skincare/ae/ingredients/niacinamide), which helps reduce pigmentation, and [hyaluronic acid](https://lovi.care/skincare/ae/ingredients/hyaluronic-acid), which helps improve skin hydration.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What is the difference between Medicube and MAC?

Medicube offers a wider range of Korean skincare products with key ingredients like niacinamide and [collagen](https://lovi.care/skincare/ae/ingredients/collagen), while MAC features a smaller selection focused on lightweight moisturizers and makeup bases. The products on this page show that Medicube tends to do better with skin texture improvement, whereas MAC excels as a makeup base and primer.

### Medicube or MAC: which moisturizer is better?

Medicube offers a wider variety of moisturizers that help deliver deep hydration, whereas MAC provides lightweight options that work well as makeup bases. Topical hyaluronic acid helps improve skin quality and signs of aging.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which is more affordable, Medicube or MAC?

Medicube is more affordable than MAC, though reviewers note small quantity and pricing issues for Medicube, and a high price point for MAC.

### Which causes fewer breakouts, Medicube or MAC?

MAC has more issues with breakouts and skin irritation than Medicube, whose products on this page help improve skin texture. Topical ingredients like niacinamide may help control skin aging and pigmentation, and topical hyaluronic acid helps improve skin quality.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Which brand has more fragrance-free products, Medicube or MAC?

Medicube has more fragrance-free products than MAC, with 23 out of 25 products on this page listing no fragrance. In contrast, all 3 products listed for MAC contain fragrance.

### Which brand is better suited for oily and acne-prone skin based on their routines?

Medicube is better suited for oily and acne-prone skin, as its brand-focused routines are specifically designed for oily skin, oily acne-prone skin, and acne-prone skin. The products on this page for Medicube feature key ingredients like niacinamide and [salicylic acid](https://lovi.care/skincare/ae/ingredients/salicylic-acid) that help manage oil and blemishes.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### How do the founding years and parent companies of Medicube and MAC compare?

Medicube was founded in South Korea in 2016 and is owned by APR Corp., while MAC was founded in Canada in 1984 and has been owned by The Estée Lauder Companies Inc. since 1994.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study](https://pubmed.ncbi.nlm.nih.gov/37377400/) Exosome cica · Journal of Cosmetic Dermatology, 2023
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo](https://pubmed.ncbi.nlm.nih.gov/12823436/) Vitamin c derivatives · Experimental Dermatology, 2003
- [Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin](https://pubmed.ncbi.nlm.nih.gov/28330776/) Aha · Journal of Dermatological Science, 2017
- [Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics](https://pubmed.ncbi.nlm.nih.gov/35223163/) Collagen, Water-soluble collagen · Dermatology Practical & Conceptual, 2022
- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Tea tree oil reduces histamine-induced skin inflammation](https://pubmed.ncbi.nlm.nih.gov/12452873/) Tree · The British Journal of Dermatology, 2002
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomilla recutita flower extract · International Journal of Molecular Medicine, 2016
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Centella asiatica extract, Madecassoside · Indian Journal of Pharmaceutical Sciences, 2016
- [Use of Collagen in Cosmetic Products](https://pubmed.ncbi.nlm.nih.gov/38534748/) Collagen, Water-soluble collagen · Current Issues in Molecular Biology, 2024
- [Effect of Camellia japonica oil on human type I procollagen production and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/17386986/) Camellia japonica seed oil · Journal of Ethnopharmacology, 2007
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32310680/) Madecassoside · Journal of Alternative and Complementary Medicine, 2020
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [Protective effects of Camellia japonica flower extract against urban air pollutants](https://pubmed.ncbi.nlm.nih.gov/30691451/) Camellia japonica flower extract · BMC Complementary and Alternative Medicine, 2019
- [Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging](https://pubmed.ncbi.nlm.nih.gov/28732847/) Bentonite · Carbohydrate Polymers, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28341613/) Dimethylmethoxy chromanol · European Journal of Pharmaceutical Sciences, 2017
- [Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study](https://pubmed.ncbi.nlm.nih.gov/30548170/) Glycolic acid · Journal of Cosmetic Dermatology, 2019
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/36501011/) Collagen extract · Nutrients, 2022
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Vitamin c derivatives · Photochemistry and Photobiology, 2021
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid, Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol](https://pubmed.ncbi.nlm.nih.gov/26517086/) Paeonia albiflora flower extract · Medical Science Monitor, 2015
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Paeonia albiflora flower extract · Molecules, 2023
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine](https://pubmed.ncbi.nlm.nih.gov/34284096/) Sophora angustifolia root extract, Sophora flavescens root extract · European Journal of Pharmaceutical Sciences, 2021
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin](https://pubmed.ncbi.nlm.nih.gov/26805418/) Lifting peptide · Journal of the European Academy of Dermatology and Venereology, 2016
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release](https://pubmed.ncbi.nlm.nih.gov/35929319/) Oenothera biennis flower extract · Biomaterials Advances, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Subclinical cutaneous inflammation remained after permeability barrier disruption enhances UV sensitivity by altering ER stress responses and topical pseudoceramide prevents them](https://pubmed.ncbi.nlm.nih.gov/28631090/) Ceramide ng · Archives of Dermatological Research, 2017
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex](https://pubmed.ncbi.nlm.nih.gov/39205505/) Succinic acid · Journal of Cosmetic Dermatology, 2024
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging](https://pubmed.ncbi.nlm.nih.gov/20883292/) Willow bark extract · Journal of Cosmetic Dermatology, 2010
- [A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/32390309/) Lauric acid · Dermatologic Therapy, 2020
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study](https://pubmed.ncbi.nlm.nih.gov/33128496/) Beta-glucan · Journal of Cosmetic Dermatology, 2021
- [Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin](https://pubmed.ncbi.nlm.nih.gov/16676123/) Paeonia albiflora flower extract · Journal of Cosmetic Science, 2006
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract](https://pubmed.ncbi.nlm.nih.gov/33410284/) Camellia japonica flower extract · FEBS Open Bio, 2021
- [Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects](https://pubmed.ncbi.nlm.nih.gov/39383579/) Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025
- [Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis](https://pubmed.ncbi.nlm.nih.gov/37763018/) Yeast extract · Journal of Clinical Medicine, 2023
- [Comparison of topical purslane & topical 0.1% triamcinolone acetonide in the management of oral lichen planus - a double blinded clinical trial](https://pubmed.ncbi.nlm.nih.gov/37726676/) Portulaca oleracea extract · BMC Oral Health, 2023
- [Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores](https://pubmed.ncbi.nlm.nih.gov/17598025/) Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins](https://pubmed.ncbi.nlm.nih.gov/17035721/) Grape seed extract · Skin Pharmacology and Physiology, 2007
- [Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract](https://pubmed.ncbi.nlm.nih.gov/35403355/) Grape seed extract · Journal of Cosmetic Dermatology, 2022
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Propanediol · Molecules, 2021
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [Composition characterization and clinical efficacy study of a salmon egg extract](https://pubmed.ncbi.nlm.nih.gov/23738607/) Salmon egg extract · International Journal of Cosmetic Science, 2013
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate vitamin e · Scientific Reports, 2025
- [Ethanolamines permeate slowly across human skin ex vivo, but cause severe skin irritation at low concentrations](https://pubmed.ncbi.nlm.nih.gov/31435711/) Ethanolamine · Archives of Toxicology, 2019
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling](https://pubmed.ncbi.nlm.nih.gov/35920724/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2022
- [Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora](https://pubmed.ncbi.nlm.nih.gov/41516097/) Sodium dna, Pdrn polydeoxyribonucleotide · International Journal of Molecular Sciences, 2025
- [Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy](https://pubmed.ncbi.nlm.nih.gov/40840755/) Sodium dna · International Journal of Biological Macromolecules, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025
- [Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41182319/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2025
- [The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/41347526/) Bentonite · Journal of Cosmetic Dermatology, 2025
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025

## The brands

- Korean skincare: [Medicube](https://lovi.care/skincare/ae/brands/medicube)
- Canadian skincare: [MAC](https://lovi.care/skincare/ae/brands/mac)

## More comparisons

- [SKIN1004 vs Medicube](https://lovi.care/skincare/ae/compare/skin1004-vs-medicube)
- [SKIN1004 vs MAC](https://lovi.care/skincare/ae/compare/skin1004-vs-mac)
- [Anua vs Medicube](https://lovi.care/skincare/ae/compare/anua-vs-medicube)
- [Anua vs MAC](https://lovi.care/skincare/ae/compare/anua-vs-mac)
- [Medicube vs The Ordinary](https://lovi.care/skincare/ae/compare/medicube-vs-the-ordinary)
- [Medicube vs Beauty of Joseon](https://lovi.care/skincare/ae/compare/medicube-vs-beauty-of-joseon)
- [Medicube vs COSRX](https://lovi.care/skincare/ae/compare/medicube-vs-cosrx)
- [Medicube vs CeraVe](https://lovi.care/skincare/ae/compare/medicube-vs-cerave)
- [Medicube vs La Roche-Posay](https://lovi.care/skincare/ae/compare/medicube-vs-la-roche-posay)
- [Medicube vs Dr. Althea](https://lovi.care/skincare/ae/compare/medicube-vs-dr-althea)
- [Medicube vs Some By Mi](https://lovi.care/skincare/ae/compare/medicube-vs-some-by-mi)
- [Medicube vs Torriden](https://lovi.care/skincare/ae/compare/medicube-vs-torriden)
- [Medicube vs celimax](https://lovi.care/skincare/ae/compare/medicube-vs-celimax)
- [Medicube vs Purito](https://lovi.care/skincare/ae/compare/medicube-vs-purito)
- [Medicube vs Cetaphil](https://lovi.care/skincare/ae/compare/medicube-vs-cetaphil)
- [Medicube vs Paula's Choice](https://lovi.care/skincare/ae/compare/medicube-vs-paula-s-choice)
- [Medicube vs Neutrogena](https://lovi.care/skincare/ae/compare/medicube-vs-neutrogena)
- [Medicube vs Kiehl's](https://lovi.care/skincare/ae/compare/medicube-vs-kiehl-s)
- [Medicube vs Caudalie](https://lovi.care/skincare/ae/compare/medicube-vs-caudalie)
- [Medicube vs Dermalogica](https://lovi.care/skincare/ae/compare/medicube-vs-dermalogica)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/medicube-vs-mac
- United Kingdom: https://lovi.care/skincare/uk/compare/medicube-vs-mac
- Ireland: https://lovi.care/skincare/ie/compare/medicube-vs-mac
- Germany: https://lovi.care/skincare/de/compare/medicube-vs-mac
- France: https://lovi.care/skincare/fr/compare/medicube-vs-mac
- Italy: https://lovi.care/skincare/it/compare/medicube-vs-mac
- Netherlands: https://lovi.care/skincare/nl/compare/medicube-vs-mac
- Spain: https://lovi.care/skincare/es/compare/medicube-vs-mac
- Canada: https://lovi.care/skincare/ca/compare/medicube-vs-mac
- Australia: https://lovi.care/skincare/au/compare/medicube-vs-mac
- Singapore: https://lovi.care/skincare/sg/compare/medicube-vs-mac
- Saudi Arabia: https://lovi.care/skincare/sa/compare/medicube-vs-mac
- United Arab Emirates: https://lovi.care/skincare/ae/compare/medicube-vs-mac (this page)