# Medicube vs Avène

Page: https://lovi.care/skincare/ae/compare/medicube-vs-avene

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Medicube and Avène are skincare brands that offer curated moisturizers, [serums](https://lovi.care/skincare/ae/ingredients/serum), toners, masks, sunscreens, and gentle cleansers featuring [niacinamide](https://lovi.care/skincare/ae/ingredients/niacinamide), [collagen](https://lovi.care/skincare/ae/ingredients/collagen), [hyaluronic acid](https://lovi.care/skincare/ae/ingredients/hyaluronic-acid), and [glycerin](https://lovi.care/skincare/ae/ingredients/glycerin). The Korean brand, founded in 2016, is revered for products that suit oily acne-prone skin and oily skin best by balancing excess sebum and hydration, while the French brand, founded in 1990, relies on science-backed formulations to ensure a calm and balanced complexion. Both brands cater effectively to oily acne-prone skin, yet they differ in their origins and specific ingredient focuses, with the former utilizing collagen and the latter utilizing glycerin to restore barrier function.

Medicube is a Korean skincare brand founded in 2016 and owned by APR Corp..

[medicubereviews.co.uk](https://medicubereviews.co.uk/medicube/story/) [glossy.co](https://www.glossy.co/beauty/medicubes-founder-on-the-products-and-people-that-fueled-the-k-beauty-brands-booming-year/)

Avène is a French skincare brand founded in 1990 and owned by Fondation Pierre Fabre.

[pierre-fabre.com](https://www.pierre-fabre.com/en/our-company/governance) [avene.co.uk](https://www.avene.co.uk/a/water-that-makes-all-the-difference-thermal-spring-water) [aveneusa.com](https://www.aveneusa.com/history)

This page compares some of the most popular Medicube and Avène products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pga9369ce45d).

### Popular Medicube vs Avène products

#### Medicube

- [Zero Pore Pad](https://lovi.care/skincare/ae/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [AED 41.99 at Amazon](https://www.amazon.ae/dp/B0CW1KV8B6?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [PDRN Pink Peptide Serum](https://lovi.care/skincare/ae/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [AED 35.00 at Amazon](https://www.amazon.ae/dp/B0DBF65JYY?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [Collagen Jelly Cream](https://lovi.care/skincare/ae/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [AED 37.99 at Amazon](https://www.amazon.ae/dp/B0CM2PPNMW?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [Collagen Night Wrapping Mask](https://lovi.care/skincare/ae/p/medicube/collagen-night-wrapping-mask/for/dry-skin) — High fit — [AED 35.00 at Amazon](https://www.amazon.ae/dp/B0BRMYHMS5?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [PDRN Pink Collagen Gel Mask](https://lovi.care/skincare/ae/p/medicube/pdrn-pink-collagen-gel-mask/for/dry-sensitive-skin) — High fit — [AED 35.00 at Amazon](https://www.amazon.ae/dp/B0DGTMR754?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [DEEP VITA-C CAPSULE CREAM](https://lovi.care/skincare/ae/p/medicube/deep-vita-c-capsule-cream/for/sensitive-skin) — Average fit — [AED 44.79 at Amazon](https://www.amazon.ae/dp/B0D2Z3GGCY?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [TRIPLE COLLAGEN CREAM](https://lovi.care/skincare/ae/p/medicube/triple-collagen-cream/for/mature-skin) — Average fit — [AED 45.99 at Amazon](https://www.amazon.ae/dp/B0BPXT3GBN?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [Zero Foam Cleanser](https://lovi.care/skincare/ae/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [AED 38.99 at Amazon](https://www.amazon.ae/dp/B09C1B7BH5?tag=lovi00-21&linkCode=osi&th=1&psc=1)

#### Avène

- [Cicalfate+ Restorative Protective Cream](https://lovi.care/skincare/ae/p/avene/cicalfate-restorative-protective-cream/for/dry-skin) — High fit — [AED 68.90 at Amazon](https://www.amazon.ae/dp/B07YBCJBG2?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [Cleanance](https://lovi.care/skincare/ae/p/avene/cleanance/for/oily-skin) — Superior fit — [AED 58.95 at Amazon](https://www.amazon.ae/dp/B000TV9RW2?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [Cleanance Cleansing Gel](https://lovi.care/skincare/ae/p/avene/cleanance-cleansing-gel/for/oily-acne-prone-skin) — High fit — [AED 76.99 at Amazon](https://www.amazon.ae/dp/B01MQWXZNV?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [Hydrance+](https://lovi.care/skincare/ae/p/avene/hydrance/for/dry-sensitive-skin) — Average fit
- [Tolerance Control Soothing Skin Recovery Balm](https://lovi.care/skincare/ae/p/avene/tolerance-control-soothing-skin-recovery-balm/for/dry-skin) — Superior fit — [AED 169.99 at Amazon](https://www.amazon.ae/dp/B08XYVMRP7?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- [RetrinAL EYES](https://lovi.care/skincare/ae/p/avene/retrinal-eyes/for/dry-skin) — High fit
- [Cold Cream](https://lovi.care/skincare/ae/p/avene/cold-cream/for/dry-sensitive-skin) — High fit
- [Vitamin Activ Cg Radiance Concentrated Serum](https://lovi.care/skincare/ae/p/avene/vitamin-activ-cg-radiance-concentrated-serum/for/mature-skin) — High fit — [AED 199.98 at Amazon](https://www.amazon.ae/dp/B0CNKJTV1X?tag=lovi00-21&linkCode=osi&th=1&psc=1)

## People Say

Medicube

Avène

- Soothing and Gentle Formulation Often Mentioned Mostly Mentioned “Calmed my angry red skin overnight — Avène Cicalfate+ Restorative Protective Cream” “leaves face clean but not dry — Avène Cleanance” “Nothing has ever worked to soothe or heal my skin like these before. — Avène Tolerance Control Soothing Skin Recovery Balm” “refreshing sensation — Medicube PDRN Pink Collagen Gel Mask”
- Hydration and Moisture Mostly Mentioned Often Mentioned “skin feels bouncier and hydrated — Medicube PDRN Pink Peptide Serum” “glass skin — Medicube PDRN Pink Collagen Gel Mask” “woke up with baby soft skin — Medicube Collagen Jelly Cream” “Restores moisture barrier — Avène Cold Cream”
- Skin Texture and Smoothing Often Mentioned Sometimes Noted “gives my skin a smooth, glass-like finish — Medicube Zero Pore Pad” “skin feels smoother — Medicube PDRN Pink Peptide Serum” “skin feels baby soft — Medicube Zero Pore Blackhead Mud Mask” “I've noticed a definite improvement in the fine lines around my eyes — Avène RetrinAL EYES”
- Glow and Radiance Often Mentioned Sometimes Noted “gave me instant glass skin — Medicube Collagen Jelly Cream” “woke up with glowing skin — Medicube Collagen Night Wrapping Mask” “Dark spots go away faster — Medicube Deep Vita C Pad” “immediate radiance boost — Avène Vitamin Activ Cg Radiance Concentrated Serum”
- Pores and Oil Control Sometimes Noted Sometimes Noted “Pores drastically reduced — Medicube Zero Foam Cleanser” “noticed a real difference in pore visibility — Medicube Zero Pore Pad” “Keeps me matte for hours — Avène Cleanance Cleansing Gel” “keeps skin matte — Avène Cleanance”
- Breakouts and Irritation Often Mentioned Sometimes Noted “caused redness and sensitivity — Medicube Zero Pore Pad” “woke up with whiteheads — Medicube Collagen Night Wrapping Mask” “Woke up with tiny whiteheads all over — Avène Cicalfate+ Restorative Protective Cream” “Caused small bumps/texture — Avène Soothing Radiance Mask”
- Strong Fragrance and Scent Often Mentioned Sometimes Noted “slightly fishy smell — Medicube PDRN Pink Peptide Serum” “smells like old lady perfume — Medicube Collagen Jelly Cream” “The fragrance is very present. — Avène Milk Cleanser” “smell is too strong — Avène Cleanance”
- Sticky and Greasy Residue Often Mentioned Sometimes Noted “Leaves a greasy film — Avène Cold Cream” “sticky kinda feeling — Avène Hyaluron Activ B3 Concentrated Plumping Serum” “too shiny — Avène Hydrance+” “hair sticks to my face — Medicube Collagen Jelly Cream”
- Packaging and Quantity Issues Often Mentioned Sometimes Noted “Tube cracked on the side — Avène Cicalfate+ Restorative Protective Cream” “Cap leaks in bag — Avène Cleanance Cleansing Gel” “Good product bad packaging. — Avène RetrinAL EYES” “tube is tiny for the price — Medicube Collagen Night Wrapping Mask”
- Product Ineffectiveness and Separation Rarely Noted Often Mentioned “didn't remove deep blackheads — Medicube Zero Pore Blackhead Mud Mask” “didn't notice any pore improvements — Medicube Zero Pore Pad” “didn't feel much help — Medicube Red Succinic Acid Peeling Pad” “bring it back — Avène Antirougeurs Fort Relief Concentrate”

### Medicube vs Avène routines for dry skin

#### Medicube-focused routine

- Cleanser: [Zero Foam Cleanser](https://lovi.care/skincare/ae/p/medicube/zero-foam-cleanser/for/dry-skin) — Superior fit — [AED 38.99 at Amazon](https://www.amazon.ae/dp/B09C1B7BH5?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/ae/p/medicube/triple-collagen-toner/for/dry-skin) — High fit — [AED 38.55 at Amazon](https://www.amazon.ae/dp/B0DW5CYSQ9?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/ae/p/medicube/age-r-booster-gel/for/dry-skin) — Superior fit — [AED 92.33 at Amazon](https://www.amazon.ae/dp/B0H4MHPRLG?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [Dr.G Green Mild Up Sun+](https://lovi.care/skincare/ae/p/dr-g/green-mild-up-sun/for/dry-skin) — Superior fit — [AED 81.00 at Amazon](https://www.amazon.ae/dp/B0B15MPMPQ?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/ae/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — [AED 35.29 at Amazon](https://www.amazon.ae/dp/B084Q16G8D?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/ae/p/medicube/zero-pore-pad/for/dry-skin) — Average fit — [AED 41.99 at Amazon](https://www.amazon.ae/dp/B0CW1KV8B6?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [One Day Exosome Shot 2000](https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-2000/for/dry-skin) — High fit — [AED 35.00 at Amazon](https://www.amazon.ae/dp/B0D16L5F2M?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [VT Cica Mild Powder Wash](https://lovi.care/skincare/ae/p/vt/cica-mild-powder-wash/for/dry-skin) — High fit — [AED 47.62 at Amazon](https://www.amazon.ae/dp/B09BFHRCG1?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week
- Nourishing Mask: [Deep Peptide Radiance Mask](https://lovi.care/skincare/ae/p/medicube/deep-peptide-radiance-mask/for/dry-skin) — High fit — [AED 49.99 at Amazon](https://www.amazon.ae/dp/B0DT6X9R7J?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week

#### Avène-focused routine

- Cleanser: [Cleanance Cleansing Gel](https://lovi.care/skincare/ae/p/avene/cleanance-cleansing-gel/for/dry-skin) — Caution fit — [AED 76.99 at Amazon](https://www.amazon.ae/dp/B01MQWXZNV?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Moisturizer: [Tolerance Control Soothing Skin Recovery Balm](https://lovi.care/skincare/ae/p/avene/tolerance-control-soothing-skin-recovery-balm/for/dry-skin) — Superior fit — [AED 169.99 at Amazon](https://www.amazon.ae/dp/B08XYVMRP7?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [Ultra Fluid](https://lovi.care/skincare/ae/p/avene/ultra-fluid/for/dry-skin) — Low fit — [AED 105.54 at Amazon](https://www.amazon.ae/dp/B0D9P3VJNG?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/ae/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — [AED 35.29 at Amazon](https://www.amazon.ae/dp/B084Q16G8D?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [ROUND LAB 1025 Dokdo Cleansing Water](https://lovi.care/skincare/ae/p/round-lab/1025-dokdo-cleansing-water/for/dry-skin) — Superior fit — [AED 38.99 at Amazon](https://www.amazon.ae/dp/B0F625GKWW?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Antirougeurs Fort Relief Concentrate](https://lovi.care/skincare/ae/p/avene/antirougeurs-fort-relief-concentrate/for/dry-skin) — Average fit — [AED 130.00 at Amazon](https://www.amazon.ae/dp/B0D33VK9Z8?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [VT Cica Mild Powder Wash](https://lovi.care/skincare/ae/p/vt/cica-mild-powder-wash/for/dry-skin) — High fit — [AED 47.62 at Amazon](https://www.amazon.ae/dp/B09BFHRCG1?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week
- Nourishing Mask: [Mediheal Watermide Essential Mask](https://lovi.care/skincare/ae/p/mediheal/watermide-essential-mask/for/dry-skin) — Superior fit — [AED 65.00 at Amazon](https://www.amazon.ae/dp/B0F6VHMDB5?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week

[Buy Medicube routine · AED 460.76 · 86% fit](https://www.amazon.ae/gp/aws/cart/add.html?ASIN.1=B09C1B7BH5&Quantity.1=1&ASIN.2=B0DW5CYSQ9&Quantity.2=1&ASIN.3=B0H4MHPRLG&Quantity.3=1&ASIN.4=B0B15MPMPQ&Quantity.4=1&ASIN.5=B084Q16G8D&Quantity.5=1&ASIN.6=B0CW1KV8B6&Quantity.6=1&ASIN.7=B0D16L5F2M&Quantity.7=1&ASIN.8=B09BFHRCG1&Quantity.8=1&ASIN.9=B0DT6X9R7J&Quantity.9=1&AssociateTag=lovi00-21) [Buy Avène routine · AED 669.42 · 77% fit](https://www.amazon.ae/gp/aws/cart/add.html?ASIN.1=B01MQWXZNV&Quantity.1=1&ASIN.2=B08XYVMRP7&Quantity.2=1&ASIN.3=B0D9P3VJNG&Quantity.3=1&ASIN.4=B084Q16G8D&Quantity.4=1&ASIN.5=B0F625GKWW&Quantity.5=1&ASIN.6=B0D33VK9Z8&Quantity.6=1&ASIN.7=B09BFHRCG1&Quantity.7=1&ASIN.8=B0F6VHMDB5&Quantity.8=1&AssociateTag=lovi00-21) [See multi-brand routine · 96% fit](https://lovi.care/skincare/ae/skin/dry-skin)

### Medicube vs Avène routines for oily skin

#### Medicube-focused routine

- Cleanser: [Red Foam Cleanser](https://lovi.care/skincare/ae/p/medicube/red-foam-cleanser/for/oily-skin) — High fit — [AED 50.50 at Amazon](https://www.amazon.ae/dp/B073ZBXSJD?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/ae/p/medicube/triple-collagen-toner/for/oily-skin) — High fit — [AED 38.55 at Amazon](https://www.amazon.ae/dp/B0DW5CYSQ9?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/ae/p/medicube/age-r-booster-gel/for/oily-skin) — High fit — [AED 92.33 at Amazon](https://www.amazon.ae/dp/B0H4MHPRLG?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/ae/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/oily-skin) — Superior fit — [AED 92.70 at Amazon](https://www.amazon.ae/dp/B08MLDY1HL?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/ae/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/oily-skin) — Superior fit — [AED 179.45 at Amazon](https://www.amazon.ae/dp/B0DNJKPSB8?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/ae/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [AED 41.99 at Amazon](https://www.amazon.ae/dp/B0CW1KV8B6?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/ae/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [AED 101.09 at Amazon](https://www.amazon.ae/dp/B001VMJSCW?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Zero Pore Blackhead Mud Mask](https://lovi.care/skincare/ae/p/medicube/zero-pore-blackhead-mud-mask/for/oily-skin) — Average fit — [AED 49.00 at Amazon](https://www.amazon.ae/dp/B0D1G7XF9X?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week

#### Avène-focused routine

- Cleanser: [Cleanance Cleansing Gel](https://lovi.care/skincare/ae/p/avene/cleanance-cleansing-gel/for/oily-skin) — High fit — [AED 76.99 at Amazon](https://www.amazon.ae/dp/B01MQWXZNV?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Some By Mi Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ae/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — [AED 49.99 at Amazon](https://www.amazon.ae/dp/B08125WDCF?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Cicalfate+ Restorative Protective Cream](https://lovi.care/skincare/ae/p/avene/cicalfate-restorative-protective-cream/for/oily-skin) — Low fit — [AED 68.90 at Amazon](https://www.amazon.ae/dp/B07YBCJBG2?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [Cleanance](https://lovi.care/skincare/ae/p/avene/cleanance/for/oily-skin) — Superior fit — [AED 58.95 at Amazon](https://www.amazon.ae/dp/B000TV9RW2?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/ae/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/oily-skin) — Superior fit — [AED 179.45 at Amazon](https://www.amazon.ae/dp/B0DNJKPSB8?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Pixi Glow Tonic](https://lovi.care/skincare/ae/p/pixi/glow-tonic/for/oily-skin) — Superior fit — [AED 120.00 at Amazon](https://www.amazon.ae/dp/B07MVYKLXT?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/ae/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [AED 101.09 at Amazon](https://www.amazon.ae/dp/B001VMJSCW?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Revision Skincare Black Mask](https://lovi.care/skincare/ae/p/revision-skincare/black-mask/for/oily-skin) — Superior fit — [AED 204.00 at Amazon](https://www.amazon.ae/dp/B08NDPYZLR?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week

[Buy Medicube routine · AED 645.61 · 87% fit](https://www.amazon.ae/gp/aws/cart/add.html?ASIN.1=B073ZBXSJD&Quantity.1=1&ASIN.2=B0DW5CYSQ9&Quantity.2=1&ASIN.3=B0H4MHPRLG&Quantity.3=1&ASIN.4=B08MLDY1HL&Quantity.4=1&ASIN.5=B0DNJKPSB8&Quantity.5=1&ASIN.6=B0CW1KV8B6&Quantity.6=1&ASIN.7=B001VMJSCW&Quantity.7=1&ASIN.8=B0D1G7XF9X&Quantity.8=1&AssociateTag=lovi00-21) [Buy Avène routine · AED 859.37 · 87% fit](https://www.amazon.ae/gp/aws/cart/add.html?ASIN.1=B01MQWXZNV&Quantity.1=1&ASIN.2=B08125WDCF&Quantity.2=1&ASIN.3=B07YBCJBG2&Quantity.3=1&ASIN.4=B000TV9RW2&Quantity.4=1&ASIN.5=B0DNJKPSB8&Quantity.5=1&ASIN.6=B07MVYKLXT&Quantity.6=1&ASIN.7=B001VMJSCW&Quantity.7=1&ASIN.8=B08NDPYZLR&Quantity.8=1&AssociateTag=lovi00-21) [See multi-brand routine · 97% fit](https://lovi.care/skincare/ae/skin/oily-skin)

### Medicube vs Avène routines for combination skin

#### Avène-focused routine

- Cleanser: [Cleanance Cleansing Gel](https://lovi.care/skincare/ae/p/avene/cleanance-cleansing-gel/for/combination-skin) — Average fit — [AED 76.99 at Amazon](https://www.amazon.ae/dp/B01MQWXZNV?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Paula's Choice Skin Balancing Pore-Reducing Toner](https://lovi.care/skincare/ae/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — [AED 145.00 at Amazon](https://www.amazon.ae/dp/B008EPPIQ4?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Hyaluron Activ B3 Concentrated Plumping Serum](https://lovi.care/skincare/ae/p/avene/hyaluron-activ-b3-concentrated-plumping-serum/for/combination-skin) — High fit — [AED 118.99 at Amazon](https://www.amazon.ae/dp/B0BNLZ4FFZ?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [Cleanance](https://lovi.care/skincare/ae/p/avene/cleanance/for/combination-skin) — High fit — [AED 58.95 at Amazon](https://www.amazon.ae/dp/B000TV9RW2?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/ae/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — [AED 179.45 at Amazon](https://www.amazon.ae/dp/B0DNJKPSB8?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Medicube Zero Pore Pad 2.0](https://lovi.care/skincare/ae/p/medicube/zero-pore-pad-2-0/for/combination-skin) — Superior fit — [AED 53.12 at Amazon](https://www.amazon.ae/dp/B09V7Z4TJG?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Vitamin Activ Cg Radiance Concentrated Serum](https://lovi.care/skincare/ae/p/avene/vitamin-activ-cg-radiance-concentrated-serum/for/combination-skin) — Average fit — [AED 199.98 at Amazon](https://www.amazon.ae/dp/B0CNKJTV1X?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/ae/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [AED 101.09 at Amazon](https://www.amazon.ae/dp/B001VMJSCW?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [KORA Organics Turmeric Brightening & Exfoliating Mask](https://lovi.care/skincare/ae/p/kora-organics/turmeric-brightening-and-exfoliating-mask/for/combination-skin) — Superior fit — [AED 122.93 at Amazon](https://www.amazon.ae/dp/B09G7PCTTG?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week

#### Medicube-focused routine

- Cleanser: [Red Foam Cleanser](https://lovi.care/skincare/ae/p/medicube/red-foam-cleanser/for/combination-skin) — High fit — [AED 50.50 at Amazon](https://www.amazon.ae/dp/B073ZBXSJD?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Triple Collagen Toner](https://lovi.care/skincare/ae/p/medicube/triple-collagen-toner/for/combination-skin) — High fit — [AED 38.55 at Amazon](https://www.amazon.ae/dp/B0DW5CYSQ9?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [AGE-R Booster Gel](https://lovi.care/skincare/ae/p/medicube/age-r-booster-gel/for/combination-skin) — High fit — [AED 92.33 at Amazon](https://www.amazon.ae/dp/B0H4MHPRLG?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/ae/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — [AED 179.45 at Amazon](https://www.amazon.ae/dp/B0DNJKPSB8?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Zero Pore Pad](https://lovi.care/skincare/ae/p/medicube/zero-pore-pad/for/combination-skin) — Superior fit — [AED 41.99 at Amazon](https://www.amazon.ae/dp/B0CW1KV8B6?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Evening
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/ae/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [AED 101.09 at Amazon](https://www.amazon.ae/dp/B001VMJSCW?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Zero Pore Blackhead Mud Mask](https://lovi.care/skincare/ae/p/medicube/zero-pore-blackhead-mud-mask/for/combination-skin) — Average fit — [AED 49.00 at Amazon](https://www.amazon.ae/dp/B0D1G7XF9X?tag=lovi00-21&linkCode=osi&th=1&psc=1) — Once a week

[Buy Avène routine · AED 1,056.50 · 88% fit](https://www.amazon.ae/gp/aws/cart/add.html?ASIN.1=B01MQWXZNV&Quantity.1=1&ASIN.2=B008EPPIQ4&Quantity.2=1&ASIN.3=B0BNLZ4FFZ&Quantity.3=1&ASIN.4=B000TV9RW2&Quantity.4=1&ASIN.5=B0DNJKPSB8&Quantity.5=1&ASIN.6=B09V7Z4TJG&Quantity.6=1&ASIN.7=B0CNKJTV1X&Quantity.7=1&ASIN.8=B001VMJSCW&Quantity.8=1&ASIN.9=B09G7PCTTG&Quantity.9=1&AssociateTag=lovi00-21) [Buy Medicube routine · AED 552.91 · 86% fit](https://www.amazon.ae/gp/aws/cart/add.html?ASIN.1=B073ZBXSJD&Quantity.1=1&ASIN.2=B0DW5CYSQ9&Quantity.2=1&ASIN.3=B0H4MHPRLG&Quantity.3=1&ASIN.4=B0DNJKPSB8&Quantity.4=1&ASIN.5=B0CW1KV8B6&Quantity.5=1&ASIN.6=B001VMJSCW&Quantity.6=1&ASIN.7=B0D1G7XF9X&Quantity.7=1&AssociateTag=lovi00-21) [See multi-brand routine · 96% fit](https://lovi.care/skincare/ae/skin/combination-skin)

## Questions and answers

### Medicube or Avène: which is better?

Both brands are great choices, but they excel in different areas based on your skin goals. Medicube products on this page stand out for providing deep hydration, radiant glow, and smoother skin texture, whereas Avène is often noted for soothing and gentle formulations. For dry sensitive skin, Lovi rates Medicube as High and Avène as Average.

### What is the difference between Medicube and Avène?

Medicube tends to focus on hydration, smoothing texture, and radiant glow with key ingredients like [niacinamide](https://lovi.care/skincare/ae/ingredients/niacinamide) and [collagen](https://lovi.care/skincare/ae/ingredients/collagen), whereas Avène emphasizes soothing formulations featuring [thermal water](https://lovi.care/skincare/ae/ingredients/thermal-water) and gentle cleansers. Both brands achieve high routine fit levels across most skin types, though Medicube is rated High for dry sensitive skin compared to Avène's Average fit.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Medicube or Avène for dry skin?

Both Medicube and Avène achieve a High Lovi fit level for dry skin. Medicube leans on hydrating ingredients like [hyaluronic acid](https://lovi.care/skincare/ae/ingredients/hyaluronic-acid) to help improve skin moisture and texture, while Avène focuses on soothing formulas like Thermal water.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Medicube or Avène: which cleanser is better?

Medicube offers a wider range of high-performing cleansers, as the products on this page show high or superior Lovi fit levels across most skin types, whereas Avène cleansers vary from high to caution depending on the skin type. Reviewers also note that Medicube cleansers provide a gentle deep clean while focusing on hydration.

### Which is more affordable, Medicube or Avène?

The products on this page for Medicube and Avene do not have pricing data provided, so it is unclear which brand is more affordable.

### Which brand has more fragrance-free products, Medicube or Avène?

Medicube offers more fragrance-free options, as 23 of the 25 products on this page list no fragrance, compared to only 7 of 15 products for Avène.

### Medicube or Avène for oily skin?

Both brands offer a high Lovi fit level for oily skin. The products on this page show that Medicube features key ingredients like niacinamide and [salicylic acid](https://lovi.care/skincare/ae/ingredients/salicylic-acid), while Avène highlights thermal water and [glycerin](https://lovi.care/skincare/ae/ingredients/glycerin).

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Medicube or Avène: which moisturizer is better?

Both Medicube and Avène offer moisturizers that help provide deep hydration. Medicube focuses on ingredients like collagen and niacinamide, which help improve skin texture and moisture retention.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Medicube or Avène for sensitive skin?

Both brands achieve a High routine fit level for sensitive skin. Medicube leans on hydrating ingredients like hyaluronic acid to help support dry skin, which topical treatments show may improve skin quality.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Medicube or Avène for acne-prone skin?

Both Medicube and Avène achieve a High Lovi fit for acne-prone skin. Medicube leans heavily on ingredients like niacinamide and salicylic acid across the products on this page to help tackle breakouts, while Avène relies heavily on thermal water and gentle formulations to soothe irritated skin.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Medicube or Avène for dry sensitive skin?

For dry sensitive skin, Medicube is a better fit with a High level, while Avène has an Average level on the products on this page. Medicube offers high hydration moisturizers like the Collagen Jelly Cream, which helps with dry skin.

[Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/)

### Medicube or Avène for oily acne-prone skin?

For oily acne-prone skin, Avène has a Superior Lovi fit level on this page, while Medicube has a High Lovi fit level. Both brands offer effective oil control and gentle deep cleansers, but Avène may be less likely to cause the sticky residue reported by reviewers of the products on this page.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid, Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study](https://pubmed.ncbi.nlm.nih.gov/37377400/) Exosome cica · Journal of Cosmetic Dermatology, 2023
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo](https://pubmed.ncbi.nlm.nih.gov/12823436/) Ascorbic acid activ cg · Experimental Dermatology, 2003
- [Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin](https://pubmed.ncbi.nlm.nih.gov/28330776/) Aha · Journal of Dermatological Science, 2017
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics](https://pubmed.ncbi.nlm.nih.gov/35223163/) Collagen, Water-soluble collagen · Dermatology Practical & Conceptual, 2022
- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Tea tree oil reduces histamine-induced skin inflammation](https://pubmed.ncbi.nlm.nih.gov/12452873/) Tree · The British Journal of Dermatology, 2002
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol, Bakuchiol · The British Journal of Dermatology, 2019
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomilla recutita flower extract · International Journal of Molecular Medicine, 2016
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Centella asiatica extract, Madecassoside · Indian Journal of Pharmaceutical Sciences, 2016
- [Use of Collagen in Cosmetic Products](https://pubmed.ncbi.nlm.nih.gov/38534748/) Collagen, Water-soluble collagen · Current Issues in Molecular Biology, 2024
- [Effect of Camellia japonica oil on human type I procollagen production and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/17386986/) Camellia japonica flower extract · Journal of Ethnopharmacology, 2007
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32310680/) Madecassoside · Journal of Alternative and Complementary Medicine, 2020
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [Protective effects of Camellia japonica flower extract against urban air pollutants](https://pubmed.ncbi.nlm.nih.gov/30691451/) Camellia japonica flower extract · BMC Complementary and Alternative Medicine, 2019
- [Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging](https://pubmed.ncbi.nlm.nih.gov/28732847/) Bentonite · Carbohydrate Polymers, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28341613/) Dimethylmethoxy chromanol · European Journal of Pharmaceutical Sciences, 2017
- [Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study](https://pubmed.ncbi.nlm.nih.gov/30548170/) Glycolic acid · Journal of Cosmetic Dermatology, 2019
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/36501011/) Collagen extract · Nutrients, 2022
- [Efficacy and tolerability assessment of a topical formulation containing copper sulfate and hypericum perforatum on patients with herpes skin lesions: a comparative, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/22270204/) Copper sulfate · Journal of Drugs in Dermatology, 2012
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Vitamin c derivatives · Photochemistry and Photobiology, 2021
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid, Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica extract, Madecassoside, Centella asiatica leaf extract · Molecules, 2023
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells](https://pubmed.ncbi.nlm.nih.gov/25940647/) Rubus idaeus fruit extract raspberry fruit extract · International Journal of Cosmetic Science, 2015
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine](https://pubmed.ncbi.nlm.nih.gov/34284096/) Sophora angustifolia root extract, Sophora flavescens root extract · European Journal of Pharmaceutical Sciences, 2021
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin](https://pubmed.ncbi.nlm.nih.gov/26805418/) Lifting peptide · Journal of the European Academy of Dermatology and Venereology, 2016
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial](https://pubmed.ncbi.nlm.nih.gov/25914553/) Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015
- [Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release](https://pubmed.ncbi.nlm.nih.gov/35929319/) Oenothera biennis flower extract · Biomaterials Advances, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study](https://pubmed.ncbi.nlm.nih.gov/36698447/) Zinc gluconate · Clinical, Cosmetic and Investigational Dermatology, 2023
- [A new dermocosmetic containing retinaldehyde, delta-tocopherol glucoside and glycylglycine oleamide for managing naturally aged skin: results from in vitro to clinical studies](https://pubmed.ncbi.nlm.nih.gov/28203099/) Tocopheryl glucoside · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Efficacy and safety of non-thermal nitrogen plasma versus long-pulsed Nd:YAG laser for hand rejuvenation](https://pubmed.ncbi.nlm.nih.gov/33420853/) Nitrogen · Lasers in Medical Science, 2022
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [New clinical approach in facial mild-moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex](https://pubmed.ncbi.nlm.nih.gov/39205505/) Succinic acid · Journal of Cosmetic Dermatology, 2024
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/33617668/) Citric acid · Journal of Cosmetic Dermatology, 2021
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging](https://pubmed.ncbi.nlm.nih.gov/20883292/) Willow bark extract · Journal of Cosmetic Dermatology, 2010
- [A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/32390309/) Lauric acid · Dermatologic Therapy, 2020
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study](https://pubmed.ncbi.nlm.nih.gov/33128496/) Beta-glucan · Journal of Cosmetic Dermatology, 2021
- [Comparative benefit of two thermal spring waters after photodynamic therapy procedure](https://pubmed.ncbi.nlm.nih.gov/17348993/) Avène thermal spring water, Avene thermal spring water avene aqua · Journal of Cosmetic Dermatology, 2007
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [Effect of seasonal and geographical differences on skin and effect of treatment with an osmoprotectant: Sorbitol](https://pubmed.ncbi.nlm.nih.gov/23752031/) Sorbitol · Journal of Cosmetic Science, 2013
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024
- [Wax-oil lubricants to reduce the shear between skin and PPE](https://pubmed.ncbi.nlm.nih.gov/34078980/) Paraffinum liquidum mineral oil · Scientific Reports, 2021
- [Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract](https://pubmed.ncbi.nlm.nih.gov/33410284/) Camellia japonica flower extract · FEBS Open Bio, 2021
- [Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects](https://pubmed.ncbi.nlm.nih.gov/39383579/) Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters](https://pubmed.ncbi.nlm.nih.gov/31437563/) Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019
- [Comparison of topical purslane & topical 0.1% triamcinolone acetonide in the management of oral lichen planus - a double blinded clinical trial](https://pubmed.ncbi.nlm.nih.gov/37726676/) Portulaca oleracea extract · BMC Oral Health, 2023
- [Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores](https://pubmed.ncbi.nlm.nih.gov/17598025/) Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins](https://pubmed.ncbi.nlm.nih.gov/17035721/) Grape seed extract · Skin Pharmacology and Physiology, 2007
- [Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract](https://pubmed.ncbi.nlm.nih.gov/35403355/) Grape seed extract · Journal of Cosmetic Dermatology, 2022
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Propanediol · Molecules, 2021
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Specific protection of sensitive skin against environmental stress by maintenance and improvement of barrier function](https://pubmed.ncbi.nlm.nih.gov/35315151/) Aquaphilus dolomiae extract filtrate · Journal of the European Academy of Dermatology and Venereology, 2022
- [TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection](https://pubmed.ncbi.nlm.nih.gov/36455708/) Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [Composition characterization and clinical efficacy study of a salmon egg extract](https://pubmed.ncbi.nlm.nih.gov/23738607/) Salmon egg extract · International Journal of Cosmetic Science, 2013
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Ethanolamines permeate slowly across human skin ex vivo, but cause severe skin irritation at low concentrations](https://pubmed.ncbi.nlm.nih.gov/31435711/) Ethanolamine · Archives of Toxicology, 2019
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Sustained effect of two antioxidants (oxothiazolidine and δ-tocopheryl glucoside) for immediate and long-term sun protection in a sunscreen emulsion based on their different penetrating properties](https://pubmed.ncbi.nlm.nih.gov/33848378/) Tocopheryl glucoside · International Journal of Cosmetic Science, 2021
- [Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/23545907/) Citric acid · Journal of Drugs in Dermatology, 2013
- [Clinical evaluation of anaesthetic-like effect of two dermocosmetic formulations containing Aquaphilus dolomiae extract-G3 in subjects with sensitive facial skin](https://pubmed.ncbi.nlm.nih.gov/35315150/) Aquaphilus dolomiae extract filtrate · Journal of the European Academy of Dermatology and Venereology, 2022
- [The Real-World Effectiveness and Tolerability of a Soothing Cream Containing the Postbiotic Aquaphilus dolomiae Extract-G2 for Skin Healing](https://pubmed.ncbi.nlm.nih.gov/38451421/) Aquaphilus dolomiae extract filtrate · Dermatology and Therapy, 2024
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin](https://pubmed.ncbi.nlm.nih.gov/32870553/) Thermal spring water, Aqua dolomiae extract · Journal of the European Academy of Dermatology and Venereology, 2020
- [Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling](https://pubmed.ncbi.nlm.nih.gov/35920724/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2022
- [Anti-Aging Efficacy of Low-Molecular-Weight Polydeoxyribonucleotide Derived from Paeonia lactiflora](https://pubmed.ncbi.nlm.nih.gov/41516097/) Sodium dna, Pdrn polydeoxyribonucleotide · International Journal of Molecular Sciences, 2025
- [Polydeoxyribonucleotide-spermidine nanoparticles: Preparation, characterization, and verification of skin anti-aging efficacy](https://pubmed.ncbi.nlm.nih.gov/40840755/) Sodium dna · International Journal of Biological Macromolecules, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025
- [Effects of Malaysian thermal spring water as adjunct therapy for mild to moderate acne vulgaris - a prospective, randomised, controlled, split face study](https://pubmed.ncbi.nlm.nih.gov/38553920/) Avène thermal spring water, Avene thermal spring water avene aqua, Thermal spring water · The Medical Journal of Malaysia, 2024
- [Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study](https://pubmed.ncbi.nlm.nih.gov/41487026/) Zinc gluconate · Journal of Cosmetic Dermatology, 2026
- [A cleanser formulated with Tris (hydroxymethyl) aminomethane and l-arginine significantly improves facial acne in male Thai subjects](https://pubmed.ncbi.nlm.nih.gov/31347768/) Arginine · Journal of Cosmetic Dermatology, 2020
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties](https://pubmed.ncbi.nlm.nih.gov/41562471/) Bakuchiol · Skin Research and Technology, 2026
- [Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41182319/) Portulaca oleracea extract · Cutaneous and Ocular Toxicology, 2025
- [The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/41347526/) Bentonite · Journal of Cosmetic Dermatology, 2025
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
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- [Dermatological Effects of a Beeswax-Pine Resin Mixture on Abdominal Skin: A Proof-of-Concept Study Supporting the Development of an Affordable Investigational Ostomy Pouching System in Low-Income Regions](https://pubmed.ncbi.nlm.nih.gov/42758164/) Beeswax cera alba cera · Journal of Wound, Ostomy, and Continence Nursing, 2026
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## The brands

- Korean skincare: [Medicube](https://lovi.care/skincare/ae/brands/medicube)
- French skincare: [Avène](https://lovi.care/skincare/ae/brands/avene)

## More comparisons

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- [SKIN1004 vs Avène](https://lovi.care/skincare/ae/compare/skin1004-vs-avene)
- [Anua vs Medicube](https://lovi.care/skincare/ae/compare/anua-vs-medicube)
- [Anua vs Avène](https://lovi.care/skincare/ae/compare/anua-vs-avene)
- [Medicube vs The Ordinary](https://lovi.care/skincare/ae/compare/medicube-vs-the-ordinary)
- [Medicube vs Beauty of Joseon](https://lovi.care/skincare/ae/compare/medicube-vs-beauty-of-joseon)
- [Medicube vs COSRX](https://lovi.care/skincare/ae/compare/medicube-vs-cosrx)
- [Medicube vs CeraVe](https://lovi.care/skincare/ae/compare/medicube-vs-cerave)
- [Medicube vs La Roche-Posay](https://lovi.care/skincare/ae/compare/medicube-vs-la-roche-posay)
- [Medicube vs Dr. Althea](https://lovi.care/skincare/ae/compare/medicube-vs-dr-althea)
- [Medicube vs Some By Mi](https://lovi.care/skincare/ae/compare/medicube-vs-some-by-mi)
- [Medicube vs Torriden](https://lovi.care/skincare/ae/compare/medicube-vs-torriden)
- [Medicube vs celimax](https://lovi.care/skincare/ae/compare/medicube-vs-celimax)
- [Medicube vs Purito](https://lovi.care/skincare/ae/compare/medicube-vs-purito)
- [Medicube vs Cetaphil](https://lovi.care/skincare/ae/compare/medicube-vs-cetaphil)
- [Medicube vs Paula's Choice](https://lovi.care/skincare/ae/compare/medicube-vs-paula-s-choice)
- [Medicube vs Neutrogena](https://lovi.care/skincare/ae/compare/medicube-vs-neutrogena)
- [Medicube vs Kiehl's](https://lovi.care/skincare/ae/compare/medicube-vs-kiehl-s)
- [Medicube vs Caudalie](https://lovi.care/skincare/ae/compare/medicube-vs-caudalie)
- [Medicube vs Dermalogica](https://lovi.care/skincare/ae/compare/medicube-vs-dermalogica)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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- Canada: https://lovi.care/skincare/ca/compare/medicube-vs-avene
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- Singapore: https://lovi.care/skincare/sg/compare/medicube-vs-avene
- Saudi Arabia: https://lovi.care/skincare/sa/compare/medicube-vs-avene
- United Arab Emirates: https://lovi.care/skincare/ae/compare/medicube-vs-avene (this page)