Bayer vs MAC

Questions and answers

Research behind their key ingredients

• The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

  Niacinamide · The British Journal of Dermatology, 2002

• Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation

  Niacinamide · Antioxidants, 2021

• Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

  Sodium hyaluronate · Dermatologic Therapy, 2022

• Effect of Camellia japonica oil on human type I procollagen production and skin barrier function

  Camellia japonica seed oil · Journal of Ethnopharmacology, 2007

• Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin

  Ceramide np · International Journal of Dermatology, 2008

• Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris

  Azelaic acid · Pharmaceutics, 2021

• Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls

  Camellia sinensis leaf extract · Experimental Dermatology, 2009

• The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

  Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017

• Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy

  Niacinamide · Journal of Cosmetic Dermatology, 2021

• The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study

  Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013

• A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population

  Salicylic acid · BioMed Research International, 2020

• Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging

  Niacinamide · Scientific Reports, 2024

• Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol

  Paeonia albiflora flower extract · Medical Science Monitor, 2015

• Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy

  Paeonia albiflora flower extract · Molecules, 2023

• Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin

  Acetyl hexapeptide-8 · Annals of Dermatology, 2019

• Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study

  Salicylic acid · Journal of Cosmetic Dermatology, 2024

• A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid

  Ceramide np · Skin Pharmacology and Physiology, 2022

• Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study

  Jojoba seed oil · Forschende Komplementarmedizin, 2012

• Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris

  Azelaic acid · Dermatology and Therapy, 2024

• A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide

  Salicylic acid · Journal of Drugs in Dermatology, 2023

• Subclinical cutaneous inflammation remained after permeability barrier disruption enhances UV sensitivity by altering ER stress responses and topical pseudoceramide prevents them

  Ceramide ng · Archives of Dermatological Research, 2017

• Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model

  Jojoba seed oil · Frontiers in Pharmacology, 2024

• The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study

  Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023

• Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract

  Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019

• The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study

  Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017

• Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin

  Paeonia albiflora flower extract · Journal of Cosmetic Science, 2006

• Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast

  Squalane · Molecules, 2025

• Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis

  Yeast extract · Journal of Clinical Medicine, 2023

• Influence of vitamin E acetate on stratum corneum hydration

  Tocopheryl acetate · Arzneimittel-Forschung, 1998

• Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum

  Caprylic capric triglyceride · Life, 2023

• Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial

  Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021

• Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial

  Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.