# A+ vs Sesderma Page: https://lovi.care/skincare/ae/compare/a-vs-sesderma The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates. A+ and Sesderma are established skincare brands founded in 1990 and 1989, respectively. A+ is beloved for its gentle moisturizers and thoughtfully calibrated formulas that suit sensitive skin best and reliably support daily moisture balance, with the 345 Relief Cream standing out for acne-prone skin. Meanwhile, the Spanish brand is known for advanced [serums](https://lovi.care/skincare/ae/ingredients/serum) and meticulously engineered formulas featuring botanical [extracts](https://lovi.care/skincare/ae/ingredients/extract) and active compounds that refine skin texture and promote a radiant complexion. While both serve sensitive skin, the latter additionally suits hyperpigmented and aging skin types best, offering targeted solutions such as the Azelac RU Serum for acne-prone skin. A+ is an Indian skincare brand founded in 1990. [pitchbook.com](https://pitchbook.com/profiles/company/554388-85) Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026. [skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html) This page compares some of the most popular A+ and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgd27839a7ab). ### Popular A+ vs Sesderma products #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [AED 123.63 at Amazon](https://www.amazon.ae/dp/B00987RKWW?tag=lovi00-21&linkCode=osi&th=1&psc=1) #### A+ - [345 Relief Cream](https://lovi.care/skincare/ae/p/a/345-relief-cream/for/sensitive-skin) — Average fit ## Questions and answers ### A+ or Sesderma: which is better? Sesderma offers a High Lovi fit for acne-prone skin and skin with dark spots with its Azelac RU [Serum](https://lovi.care/skincare/ae/ingredients/serum), while A+ products on this page show Average or Low fits across skin types. [Azelaic acid](https://lovi.care/skincare/ae/ingredients/azelaic-acid) helps in the treatment of acne vulgaris. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### What is the difference between A+ and Sesderma? Sesderma achieves a High Lovi fit for skin with dark spots with its Azelac RU Serum, whereas A+ products on this page get an Average fit for those concerns. Additionally, the products on this page from A+ list no fragrance, while Sesderma includes fragrance in its serum. ### Which is more affordable, A+ or Sesderma? This page does not provide pricing or affordability information for either A+ or Sesderma. ### Which causes fewer breakouts, A+ or Sesderma? For acne-prone skin, Sesderma has a High Lovi fit with Azelac RU Serum, whereas A+ products on this page have an Average fit. Azelaic acid helps manage acne vulgaris. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### Where were A+ and Sesderma founded? A+ was founded in India, and Sesderma was founded in Spain. ### Which brand offers products with no fragrance listed in their ingredients? A+ offers products with no fragrance listed in their ingredients, as every product on this page from the brand is formulated without fragrance. ### How does the Lovi fit level for combination skin compare between A+ and Sesderma's featured products? For combination skin, Sesderma's Azelac RU Serum achieves a High Lovi fit level, whereas A+'s 345 Relief Cream reaches only a Low fit level. Sesderma's product also contains fragrance, while A+'s product lists no fragrance. ## Research behind their key ingredients - [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000 - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002 - [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007 - [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008 - [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007 - [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017 - [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021 - [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017 - [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024 - [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica leaf extract · Molecules, 2023 - [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022 - [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998 - [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 - [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024 ## The brands - Indian skincare: [A+](https://lovi.care/skincare/ae/brands/a) - Spanish skincare: [Sesderma](https://lovi.care/skincare/ae/brands/sesderma) ## More comparisons - [SKIN1004 vs A+](https://lovi.care/skincare/ae/compare/skin1004-vs-a) - [SKIN1004 vs Sesderma](https://lovi.care/skincare/ae/compare/skin1004-vs-sesderma) - [Anua vs A+](https://lovi.care/skincare/ae/compare/anua-vs-a) - [Anua vs Sesderma](https://lovi.care/skincare/ae/compare/anua-vs-sesderma) - [Medicube vs A+](https://lovi.care/skincare/ae/compare/medicube-vs-a) - [Medicube vs Sesderma](https://lovi.care/skincare/ae/compare/medicube-vs-sesderma) - [The Ordinary vs A+](https://lovi.care/skincare/ae/compare/the-ordinary-vs-a) - [The Ordinary vs Sesderma](https://lovi.care/skincare/ae/compare/the-ordinary-vs-sesderma) - [Beauty of Joseon vs A+](https://lovi.care/skincare/ae/compare/beauty-of-joseon-vs-a) - [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/ae/compare/beauty-of-joseon-vs-sesderma) - [COSRX vs A+](https://lovi.care/skincare/ae/compare/cosrx-vs-a) - [COSRX vs Sesderma](https://lovi.care/skincare/ae/compare/cosrx-vs-sesderma) - [CeraVe vs A+](https://lovi.care/skincare/ae/compare/cerave-vs-a) - [CeraVe vs Sesderma](https://lovi.care/skincare/ae/compare/cerave-vs-sesderma) - [La Roche-Posay vs A+](https://lovi.care/skincare/ae/compare/la-roche-posay-vs-a) - [La Roche-Posay vs Sesderma](https://lovi.care/skincare/ae/compare/la-roche-posay-vs-sesderma) - [Dr. Althea vs A+](https://lovi.care/skincare/ae/compare/dr-althea-vs-a) - [Dr. Althea vs Sesderma](https://lovi.care/skincare/ae/compare/dr-althea-vs-sesderma) - [Some By Mi vs A+](https://lovi.care/skincare/ae/compare/some-by-mi-vs-a) - [Some By Mi vs Sesderma](https://lovi.care/skincare/ae/compare/some-by-mi-vs-sesderma) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/a-vs-sesderma - United Kingdom: https://lovi.care/skincare/uk/compare/a-vs-sesderma - Ireland: https://lovi.care/skincare/ie/compare/a-vs-sesderma - Germany: https://lovi.care/skincare/de/compare/a-vs-sesderma - France: https://lovi.care/skincare/fr/compare/a-vs-sesderma - Italy: https://lovi.care/skincare/it/compare/a-vs-sesderma - Netherlands: https://lovi.care/skincare/nl/compare/a-vs-sesderma - Spain: https://lovi.care/skincare/es/compare/a-vs-sesderma - Canada: https://lovi.care/skincare/ca/compare/a-vs-sesderma - Australia: https://lovi.care/skincare/au/compare/a-vs-sesderma - Singapore: https://lovi.care/skincare/sg/compare/a-vs-sesderma - Saudi Arabia: https://lovi.care/skincare/sa/compare/a-vs-sesderma - United Arab Emirates: https://lovi.care/skincare/ae/compare/a-vs-sesderma (this page)